Patents by Inventor Jingshu TANG

Jingshu TANG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IgG EPITOPE AND APPLICATIONS THEREOF AS A DRUG TARGET
    Publication number: 20200369785
    Abstract: IgG epitope and applications thereof as a target are provided. The IgG epitope is the CH1 domain of non-B cell-derived IgG, and there is N-glycosylated sialic acid modification at the Asn162 site of the domain. The realization of its antigen functions must depend on the sialylation of the site. The present invention further discloses the applications of the IgG epitope as a drug target in preparing drugs for diagnosis and/or treatment of epithelial tumors. In addition, our studies showed that this antigen depends on the sialylation of Asn162 site as a drug target, and the sialylation of this site must depend on sialyltransferase ST3GAL4, indicating that the enzyme can be used as a drug target for preparing tumor therapeutic drugs. Further, integrin ?4 is co-expressed and co-localized with IgG containing the epitope. IgG can be used as a marker for preparing drugs for the auxiliary detection of epithelial tumors.
    Type: Application
    Filed: August 8, 2018
    Publication date: November 26, 2020
    Applicant: Beijing SIG Biopharmaceutical Technology Co., Ltd.
    Inventors: Xiaoyan QIU, Jingshu TANG, Zhi YANG, Chong WANG, Jingxuan ZHANG, Hua ZHU, Zihan GENG, Yang LIU, Wenhua JIANG, Jing HUANG
  • Thiazolopyrimidinone compounds and preparation methods and use thereof
    Patent number: 10450326
    Abstract: The present invention provides structural details of a thiazolopyrimidinone compound, a preparation method thereof, and use thereof in the manufacture of a medicament for the treatment of central nervous system diseases.
    Type: Grant
    Filed: June 3, 2016
    Date of Patent: October 22, 2019
    Assignee: PEKING UNIVERSITY
    Inventors: Kewei Wang, Qi Sun, Wenxuan Jiao, Jingshu Tang
  • THIAZOLOPYRIMIDINONE COMPOUNDS AND PREPARATION METHODS AND USE THEREOF
    Publication number: 20180155366
    Abstract: The present invention provides structural details of a thiazolopyrimidinone compound, a preparation method thereof, and use thereof in the manufacture of a medicament for the treatment of central nervous system diseases.
    Type: Application
    Filed: June 3, 2016
    Publication date: June 7, 2018
    Applicant: PEKING UNIVERSITY
    Inventors: Kewei WANG, Qi SUN, Wenxuan JIAO, Jingshu TANG