Patents by Inventor Jingsong Chen
Jingsong Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 11969354Abstract: The invention relates to medical implants, including spinal implants and bone grafts, for fixation and integration with hard tissue. The bone medical implants include at least one rotational fixation mechanism that further includes or is attached to one or more sharp protrusions configured to penetrate and become lodged into hard tissue to provide support and positional stability. Such support is useful to ensure that the spinal bone graft may be used without additional stabilizing or anchoring structures, such as supporting plates or screws.Type: GrantFiled: August 12, 2021Date of Patent: April 30, 2024Assignee: LifeNet HealthInventors: Jingsong Chen, Dennis Phelps, Andy T. Pritchard, Nathan Kemper, Thomas Brewer
-
Publication number: 20240119314Abstract: A method and a device for predicting gene coding breeding based on graph clustering. According to the present disclosure, a gene map is constructed based on inter-gene correlation strength; the gene map is subjected to clustering solution to obtain a number of co-regulated genomes and a genome cluster number information of each gene; gene allelic information and genome cluster number information are fused to obtain the gene cluster code of the sample; based on gene cluster code information and biological phenotype information to be predicted, a deep convolutional neural network is constructed to optimize the prediction performance of genetic breeding.Type: ApplicationFiled: August 22, 2023Publication date: April 11, 2024Inventors: Jingsong LV, Hongyang CHEN, Hao WANG, Xianzhong FENG
-
Publication number: 20240099856Abstract: A spinal bone graft includes one or more cortical bone portions forming a first unit. The first unit includes an engagement surface for contacting bone, and a mating surface. The mating surface forms at least one first undercut. The bone graft also includes one or more cortical bone portions forming a second unit. The second unit includes an engagement surface for contacting bone, and a mating surface. The mating surface forms either at least one second undercut, or at least one connector. In the former, at least one connector is received in each of the first and second undercuts to interconnect the first and second units. In the latter, the at least one connector of the second unit is received in the first undercut of the first unit to interconnect the first unit and second unit.Type: ApplicationFiled: December 4, 2023Publication date: March 28, 2024Applicant: LifeNet HealthInventors: Mark Evans, Dennis Phelps, Jingsong Chen
-
Publication number: 20240009352Abstract: The present invention provides demineralized bone fibers exhibiting optimal handling properties (e.g., high moldability and low elastic modulus) and biological activities (e.g., osteoinductivity) as well as non-demineralized bone fibers useful for preparing the demineralized bone fibers. A well-controlled demineralization process for preparing the demineralized bone of fibers is also provided. Products comprising the demineralized bone fibers and uses thereof are further provided.Type: ApplicationFiled: September 20, 2023Publication date: January 11, 2024Applicant: LifeNet HealthInventors: Silvia Chen, Grant Cleavenger, Dennis Phelps, Breanne Gjurich, Evans Wralstad, Austin Johnson, Alana Sampson, Adam Entsminger, Jingsong Chen
-
Patent number: 11865015Abstract: A spinal bone graft includes one or more cortical bone portions forming a first unit. The first unit includes an engagement surface for contacting bone, and a mating surface. The mating surface forms at least one first undercut. The bone graft also includes one or more cortical bone portions forming a second unit. The second unit includes an engagement surface for contacting bone, and a mating surface. The mating surface forms either at least one second undercut, or at least one connector. In the former, at least one connector is received in each of the first and second undercuts to interconnect the first and second units. In the latter, the at least one connector of the second unit is received in the first undercut of the first unit to interconnect the first unit and second unit.Type: GrantFiled: July 21, 2022Date of Patent: January 9, 2024Assignee: LifeNet HealthInventors: Mark Evans, Dennis Phelps, Jingsong Chen
-
Publication number: 20230301683Abstract: The present invention provides a cannula for delivering a tissue graft to a treatment site. The cannula comprises a distal end, a proximal end, a bore formed by an interior surface of the cannula, extending from the distal end to the proximal end and having a diameter, and a tissue graft inside the bore and in contact with the interior surface. The tissue graft may be released from the cannula at the distal end to the treatment site. The tissue graft may have a final loading pressure of 20-200 psi. Also provided is a delivery system comprising the cannula and a delivery device. Further provided are methods for delivering a tissue graft in a cannula to a treatment site and methods for preparing a cannula loaded with the tissue graft.Type: ApplicationFiled: August 10, 2021Publication date: September 28, 2023Applicant: LifeNet HealthInventors: Adam Entsminger, Cheryl Berger, Michael Masters, Kevin Shores, Erich Lohmann, Jingsong Chen
-
Publication number: 20230101122Abstract: The present invention provides a product comprising plated human hepatocytes on a surface and at least some of the plated hepatocytes are in one or more hepatocyte clusters on feeder cells, which are attached to the surface. A method of preparing plated human hepatocytes is also provided. The preparation method comprises applying human hepatocytes to a surface in the presence of feeder cells, co-culturing the applied hepatocytes with the feeder cells, and forming one or more hepatocyte clusters by the co-cultured hepatocytes on the feeder cells, which are attached to the surface. The plated hepatocytes may be used for various purposes, including the preparation of a hepatitis B virus (HBV) infected hepatocyte culture model and drug testing.Type: ApplicationFiled: December 5, 2022Publication date: March 30, 2023Applicant: LifeNet HealthInventors: Jung Bok Lee, Angela Murchison, Edward LeCluyse, Jingsong Chen
-
Publication number: 20230079283Abstract: The present invention is directed to methods for collecting and processing autografts, processed autografts, kits for collecting and transporting autografts, and tools for preparing autografts. It is also directed to autologous bone grafts, and methods of preparing them.Type: ApplicationFiled: November 18, 2022Publication date: March 16, 2023Applicant: LifeNet HealthInventors: Roberto Bracone, Jingsong Chen, Marilyn Gatin, Silvia Chen, James A. Clagett, Daniel Osborne
-
Patent number: 11533906Abstract: The present invention is directed to methods for collecting and processing autografts, processed autografts, kits for collecting and transporting autografts, and tools for preparing autografts. It is also directed to autologous bone grafts, and methods of preparing them.Type: GrantFiled: November 23, 2020Date of Patent: December 27, 2022Assignee: LIFENET HEALTHInventors: Roberto Bracone, Jingsong Chen, Marilyn Gatin, Silvia Chen, James A. Clagett, Daniel Osborne
-
Patent number: 11535827Abstract: The present invention provides a product comprising plated human hepatocytes on a surface and at least some of the plated hepatocytes are in one or more hepatocyte clusters on feeder cells, which are attached to the surface. A method of preparing plated human hepatocytes is also provided. The preparation method comprises applying human hepatocytes to a surface in the presence of feeder cells, co-culturing the applied hepatocytes with the feeder cells, and forming one or more hepatocyte clusters by the co-cultured hepatocytes on the feeder cells, which are attached to the surface. The plated hepatocytes may be used for various purposes, including the preparation of a hepatitis B virus (HBV) infected hepatocyte culture model and drug testing.Type: GrantFiled: September 22, 2018Date of Patent: December 27, 2022Assignee: LifeNet HealthInventors: Jung Bok Lee, Angela Murchison, Edward LeCluyse, Jingsong Chen
-
Publication number: 20220354666Abstract: A spinal bone graft includes one or more cortical bone portions forming a first unit. The first unit includes an engagement surface for contacting bone, and a mating surface. The mating surface forms at least one first undercut. The bone graft also includes one or more cortical bone portions forming a second unit. The second unit includes an engagement surface for contacting bone, and a mating surface. The mating surface forms either at least one second undercut, or at least one connector. In the former, at least one connector is received in each of the first and second undercuts to interconnect the first and second units. In the latter, the at least one connector of the second unit is received in the first undercut of the first unit to interconnect the first unit and second unit.Type: ApplicationFiled: July 21, 2022Publication date: November 10, 2022Applicant: LifeNet HealthInventors: Mark Evans, Dennis Phelps, Jingsong Chen
-
Patent number: 11395746Abstract: A spinal bone graft includes one or more cortical bone portions forming a first unit. The first unit includes an engagement surface for contacting bone, and a mating surface. The mating surface forms at least one first undercut. The bone graft also includes one or more cortical bone portions forming a second unit. The second unit includes an engagement surface for contacting bone, and a mating surface. The mating surface forms either at least one second undercut, or at least one connector. In the former, at least one connector is received in each of the first and second undercuts to interconnect the first and second units. In the latter, the at least one connector of the second unit is received in the first undercut of the first unit to interconnect the first unit and second unit.Type: GrantFiled: November 9, 2020Date of Patent: July 26, 2022Assignee: LifeNet HealthInventors: Mark Evans, Dennis Phelps, Jingsong Chen
-
Publication number: 20220184279Abstract: A method of preparing a decellularized placental membrane is provided. The method comprises removing cells from a pre-decellularized placental membrane comprising an amnion layer and a chorion layer to produce a decellularized placental membrane without separating the amnion layer from the chorion layer. The pre-decellularized placental membrane is obtained from an amniotic sac, and the decellularized placental membrane comprises the amnion layer and the chorion layer. Also provided is a decellularized placental membrane and a placenta-derived graft comprising the decellularized placental membrane. Further provided are the uses of the decellularized placental membrane or the placenta-derived graft.Type: ApplicationFiled: December 20, 2021Publication date: June 16, 2022Applicant: LifeNet HealthInventors: Xiaofei Qin, Silvia Chen, Lindsey Aschenbach, Jingsong Chen
-
Publication number: 20220151765Abstract: Soft tissue supports, soft tissue implants, and methods of making and using soft tissue supports are disclosed. One soft tissue support includes a unitary piece of processed porous tissue material having an anterior portion and a posterior portion. The anterior and posterior portions define a cavity therebetween. The cavity is sized to receive a breast implant therein. The cavity has at least one opening sized to receive the breast implant therethrough. One soft tissue implant includes the soft tissue support and a breast implant positioned within the cavity of the soft tissue support. The implant may further include a soft tissue graft configured to support the processed porous tissue material and the breast implant. A method of using a soft tissue support includes inserting a breast implant into the soft tissue support, and implanting the soft tissue support containing the breast implant in the cavity.Type: ApplicationFiled: March 20, 2020Publication date: May 19, 2022Applicant: LifeNet HealthInventors: Xiaofei Qin, Michael LaPrade, Jingsong Chen, Joshua Jones, Austin Johnson, Erich Lohmann
-
Publication number: 20220152120Abstract: The present invention provides a composition for treating a pathological condition in a body part of a patient in needed thereof, comprising an effective amount of a birth tissue elute or birth tissue particulates. A method for preparing the birth tissue elute, for example, an umbilical cord elute, is also provided. A method for treating a pathological condition in a body part of a patient in needed thereof is further provided.Type: ApplicationFiled: April 16, 2020Publication date: May 19, 2022Applicant: LifeNet HealthInventors: Xiaofei Qin, Fanwei Meng, Jingsong Chen
-
Publication number: 20220079769Abstract: The invention relates to medical implants, including spinal implants and bone grafts, for fixation and integration with hard tissue. The bone medical implants include at least one rotational fixation mechanism that further includes or is attached to one or more sharp protrusions configured to penetrate and become lodged into hard tissue to provide support and positional stability. Such support is useful to ensure that the spinal bone graft may be used without additional stabilizing or anchoring structures, such as supporting plates or screws.Type: ApplicationFiled: August 12, 2021Publication date: March 17, 2022Applicant: LifeNet HealthInventors: Jingsong Chen, Dennis Phelps, Andy T. Pritchard, Nathan Kemper, Thomas Brewer
-
Patent number: 11253297Abstract: A pin made of cortical bone may be inserted into adjoining bones of a toe to align and secure the bones. The pin may have barbs to prevent migration of the pin. The pin may include a shoulder to further prevent migration of the pin from the bones, to increase the strength of the pin, and to increase the surface area between the bone pin and the host bone. The pin may further include flattened portions on its circumference to aide in rotating the pin during insertion. The pin may be treated to reduce brittleness.Type: GrantFiled: April 9, 2020Date of Patent: February 22, 2022Assignee: LIFENET HEALTHInventors: Jingsong Chen, Thomas Sander, Dennis Phelps, Andy Pritchard, Roberto Bracone
-
Patent number: 11207446Abstract: A method of preparing a decellularized placental membrane is provided. The method comprises removing cells from a pre-decellularized placental membrane comprising an amnion layer and a chorion layer to produce a decellularized placental membrane without separating the amnion layer from the chorion layer. The pre-decellularized placental membrane is obtained from an amniotic sac, and the decellularized placental membrane comprises the amnion layer and the chorion layer. Also provided is a decellularized placental membrane and a placenta-derived graft comprising the decellularized placental membrane. Further provided are the uses of the decellularized placental membrane or the placenta-derived graft.Type: GrantFiled: December 23, 2016Date of Patent: December 28, 2021Assignee: LifeNet HealthInventors: Xiaofei Qin, Silvia Chen, Lindsey Aschenbach, Jingsong Chen
-
Publication number: 20210322173Abstract: A shaped cartilage matrix isolated from a human or animal where the cartilage has been crafted to facilitate disinfection, cleaning, devitalization, recellularization, and/or integration after implantation. Also, a process for repairing a cartilage defect with the cartilage matrix. The matrix is in the form of an osteochondral plug including a cartilage cap ad subchondral bone, wherein one or more gaps, slats, bores, or channels extend through the tidemark at the interface between the cartilage cap and the subchondral bone.Type: ApplicationFiled: June 3, 2021Publication date: October 21, 2021Applicant: LifeNet HealthInventors: Silvia Sihui Chen, Xiaofei Qin, Jingsong Chen, Lloyd Wolfinbarger, JR.
-
Patent number: 11147674Abstract: A shaped cartilage matrix isolated from a human or animal where the cartilage has been crafted to facilitate disinfection, cleaning, devitalization, recellularization, and/or integration after implantation. Also, a process for repairing a cartilage defect with the cartilage matrix. The matrix is in the form of an osteochondral plug including a cartilage cap ad subchondral bone, wherein one or more gaps, slats, bores, or channels extend through the tidemark at the interface between the cartilage cap and the subchondral bone.Type: GrantFiled: July 27, 2017Date of Patent: October 19, 2021Assignee: LifeNet HealthInventors: Silvia Sihui Chen, Xiaofei Qin, Jingsong Chen, Lloyd Wolfinbarger, Jr.