Abstract: Disclosed is a method and a system for discovering adverse drug reaction signals based on causal discovery. According to the present application, a causality is introduced in the process of discovering adverse drug reaction signals by using electronic medical record data, the data dimension in real-world electronic medical record data is maximally reserved, a Bayesian network structure containing causal effects, as well as a set of confounding factors which plays a role in both a medication intervention and an occurrence of an adverse event are constructed. The method of constructing the set of confounding factors starts from the data, without artificial access and prior knowledge, and retains the confounding factors in the real world to the greatest extent. A medication intervention group and a control group are constructed based on these confounding factors, and the randomized controlled trial is simulated.

Abstract: Disclosed is a method and an apparatus NER-orientated Chinese clinical text data augmentation, and unannotated data and annotated data of label linearization processing through data preprocessing. A concealed part is predicted based on retained information by using the unannotated data and concealing part of information in text, and meanwhile an entity word-level discrimination task is introduced for pre-training of a span-based language model; and a plurality of decoding mechanisms are introduced in a fine-tune stage, a relationship between a text vector and text data is obtained based on the pre-trained span-based language model, linearized data with entity labels is converted into the text vector, and text generation is performed through forward decoding and reverse decoding in a prediction stage of a text generation model to obtain enhanced data with annotation information.

Abstract: The present disclosure discloses a general speech enhancement method and apparatus using multi-source auxiliary information. The method includes following steps: S1: building a training data set; S2: using the training data set to learn network parameters of a model, and building a speech enhancement model; S3: building a sound source information database in a pre-collection or on-site collection mode; S4: acquiring an input of the speech enhancement model; and S5: taking a noisy original signal as a main input of the speech enhancement model, taking auxiliary sound signals of a target source group and auxiliary sound signals of an interference source group as side inputs of the speech enhancement model for speech enhancement, and obtaining an enhanced speech signal.

Abstract: The present application discloses a system and a device for functional connectivity matrix processing based on feature selection using a filtering method, which comprises the following steps: acquiring a preprocessed resting state brain functional magnetic resonance image of a subject; extracting time series; calculating a Pearson correlation coefficient to obtain a Pearson correlation coefficient matrix; vectorizing the Pearson correlation coefficient matrix; calculating quantitative correlation indices using a filtering method, and selecting a quantitative correlation index based on a preset threshold; performing weighting processing a selected functional connectivity feature by using the corresponding quantitative correlation index with high correlation with a disease diagnosis result to obtain a functional connectivity matrix; and obtaining a prediction result from the functional connectivity matrix.

Abstract: The present disclosure discloses a medical ETL task dispatching method, system and apparatus based on multiple centers. The method includes following steps: step S1: testing and verifying ETL tasks; step S2: deploying the ETL tasks to a hospital center, and dispatching the ETL tasks to a plurality of executors for execution; step S3: screening an executor set meeting resource demands of ETL tasks to be dispatched; step S4: calculating a current task load of each executor in the executor set; step S5: selecting the executor with a minimum current task load to execute the ETL tasks; and step S6: selecting, by the dispatching machine, the ETL tasks from executor active queues according to a priority for execution. The present disclosure selects the most suitable executor by analyzing a serving index as a task to be dispatched on a current dispatching machine.

Abstract: Disclosed is a LADCP and USBL combined observation device and a use method thereof. The device includes a cable winch system, a mounting frame, a LADCP system, a USBL beacon and a correction system. The LADCP system, the USBL beacon and the correction system can be mounted to the mounting frame by adopting a hardware support platform. The cable winch system can drive the LADCP system to deploy or recover along a vertical section. The LADCP system is used to obtain the current velocity of a single small profile, and the USBL beacon can locate the underwater position information, and the correction system can obtain data information in the seawater where the mounting frame is located, so as to calculate an absolute current velocity according to the velocity obtained by the LADCP system and the current data obtained by the correction system.

Abstract: The present disclosure relates in its first aspect to a process of converting a stream comprising methane into chemicals, said process being remarkable in that it comprises the steps of providing a first stream (1, 5, 11) comprising methane, providing a second stream (79) which is a bromine-rich stream, putting into contact said first stream (15) with said second stream (79) to obtain a third stream (21) comprising at least unreacted methane, methyl bromide, dibromomethane, and hydrogen bromide and removing said dibromomethane from said third stream (21), to produce a dibromomethane stream (103) and a fourth stream (27) comprising unreacted methane, methyl bromide and hydrogen bromide; wherein the fourth stream (27) is converted into chemicals. In its second aspect, the present disclosure concerns an installation for carrying out the process of the first aspect.

Abstract: The disclosure relates in its first aspect to a process of conversion of a gaseous stream comprising methane into hydrogen (51) and carbon (25), the process is remarkable in that it comprises a step (a) of providing a first gaseous stream (3, 7); a step (b) of bromination and synthesis in which the first gaseous stream (3, 7) is put in contact with a second stream (53) comprising bromine resulting in the formation of a third stream (15) comprising methyl bromides and hydrogen bromide, and of a fourth stream (25) comprising carbon including graphite and/or carbon black; a step (c) of separation performed on the third stream (15) to recover a hydrogen bromide-rich stream (41) which is then oxidized in a step (d) to produce a stream (51) comprising hydrogen. The second aspect relates to the installation for performing the process of the first aspect and the third aspect concerns the use of bromine in such process.

Abstract: A bio-oil light fraction-based bread-shaped porous activated carbon, a method for preparing the same and use thereof are provided. A light fraction prepared by fast pyrolysis of a biomass coupled with molecular distillation is selected as a precursor; an activator is directly mixed with the light fraction and stirred to obtain a homogeneous liquid; then, the homogeneous liquid is subjected to one-step carbonization and activation at a two-stage temperature in an inert atmosphere; after the activation, the obtained solid was washed and filtered, the activator reaction products and impurities are removed, and then dried to obtain the activated carbon used as an electrode carbon material of a supercapacitor. The method fully utilizes the rich micromolecule compounds such as water, acids, ketones, aldehydes, monophenols and the like in the obtained light fraction, and the micromolecule compounds and water can interact with the activator.

Abstract: Methods of selecting a subject for treatment of amyotrophic lateral sclerosis (ALS) and methods of treatment for subjects having ALS or at risk of developing ALS are provided. The method of selecting subjects for treatment includes obtaining a biological sample from the subject, where the sample is obtained from the subject's gastrointestinal tract or skeletal muscle. The method further includes measuring a biomarker in the subject's sample and selecting the subject for treatment of ALS when the biomarker measurement in the subject's sample is lower or higher relative to a control measurement.

Abstract: A device can be configured to provide isolation between conductive circuit paths and to selectively connect one of the conductive circuit paths to a shared interface. Each conductive circuit path can include driver circuitry designed to transmit signals according to a particular protocol and a corresponding signal speed. The shared interface can be, in one instance, a connector designed for connection to other devices. The other devices can be configured to communicate over the shared interface using one or more of the particular protocols provided using the different circuit paths.

Abstract: Methods of selecting a subject for treatment of amyotrophic lateral sclerosis (ALS) and methods of treatment for subjects having ALS or at risk of developing ALS are provided. The method of selecting subjects for treatment includes obtaining a biological sample from the subject, where the sample is obtained from the subject's gastrointestinal tract or skeletal muscle. The method further includes measuring a biomarker in the subject's sample and selecting the subject for treatment of ALS when the biomarker measurement in the subject's sample is lower or higher relative to a control measurement.

Abstract: A device can be configured to provide isolation between conductive circuit paths and to selectively connect one of the conductive circuit paths to a shared interface. Each conductive circuit path can include driver circuitry designed to transmit signals according to a particular protocol and a corresponding signal speed. The shared interface can be, in one instance, a connector designed for connection to other devices. The other devices can be configured to communicate over the shared interface using one or more of the particular protocols provided using the different circuit paths.

Abstract: A data link circuit switches high-speed signals through FET-based circuitry between channels. A FET responds to control signals at the gate terminal to operate in either a signal-passing mode or another (blocking) mode. In the passing mode, an AC (high-speed) signal is passed between the S-D terminals by coupling a first signal portion (of the AC signal) and with another signal portion diverted by the inherent capacitances associated with the FET. For offsetting the loading caused by the inherent capacitances associated with the FET-based switch, a biasing circuit is configured and arranged to bias the back-gate terminal of the FET transistor with a follower signal.

Abstract: A data link circuit switches high-speed signals through FET-based circuitry between channels. A FET responds to control signals at the gate terminal to operate in either a signal-passing mode or another (blocking) mode. In the passing mode, an AC (high-speed) signal is passed between the S-D terminals by coupling a first signal portion (of the AC signal) and with another signal portion diverted by the inherent capacitances associated with the FET. For offsetting the loading caused by the inherent capacitances associated with the FET-based switch, a biasing circuit is configured and arranged to bias the back-gate terminal of the FET transistor with a follower signal.

Abstract: A device can be configured to provide isolation between conductive circuit paths and to selectively connect one of the conductive circuit paths to a shared interface. Each conductive circuit path can include driver circuitry designed to transmit signals according to a particular protocol and a corresponding signal speed. The shared interface can be, in one instance, a connector designed for connection to other devices. The other devices can be configured to communicate over the shared interface using one or more of the particular protocols provided using the different circuit paths.