Patents by Inventor Jingwu Duan

Jingwu Duan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Macrocyclic compounds as metalloprotease inhibitors
    Patent number: 6281352
    Abstract: This invention relates to macrocyclic molecules which inhibit metalloproteinases, including aggrecanase, and the production of tumor necrosis factor (TNF). In particular, the compounds are inhibitors of metalloproteinases involved in tissue degradation and inhibitors of the release of tumor necrosis factor. The present invention also relates to pharmaceutical compositions comprising such compounds and to methods of using these compounds for the treatment of inflammatory diseases.
    Type: Grant
    Filed: May 14, 1997
    Date of Patent: August 28, 2001
    Assignee: DuPont Pharmaceuticals Company
    Inventors: Chu-Bio Xue, Carl P. Decicco, Robert J. Cherney, Elizabeth Arner, William F. DeGrado, Jingwu Duan, Xiaohua He, Irina Cipora Jacobson, Ronald L. Magolda, David Nelson
  • Lactam metalloprotease inhibitors
    Patent number: 6057336
    Abstract: The present application describes novel lactams and derivatives thereof of formula I: ##STR1## or pharmaceutically acceptable salt forms thereof, wherein rings ring B is a 4-8 membered cyclic amide containing from 0-3 additional heteroatoms selected from N, O, and S, which are useful as metalloprotease inhibitors.
    Type: Grant
    Filed: October 2, 1998
    Date of Patent: May 2, 2000
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Jingwu Duan, Carl P. Decicco, Zelda R. Wasserman, Thomas P. Maduskuie, Jr.