Patents by Inventor Jingwu Xie

Jingwu Xie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR TREATING AORTIC VALVE STENOSIS WITH A HEDGEHOG PATHWAY INHIBITOR
    Publication number: 20240390305
    Abstract: Methods of treating a valvular heart disease are provided. Methods for treating valvular heard disease include administering to a subject a therapeutically effective amount of at least one hedgehog pathway inhibitor. Also provided are methods for reducing fibrosis in a subject, which comprise administering to the subject a therapeutically effective amount of at least one hedgehog pathway inhibitor.
    Type: Application
    Filed: August 6, 2024
    Publication date: November 28, 2024
    Applicant: The Trustees of Indiana University
    Inventor: Jingwu Xie
  • Methods for treating pulmonary fibrosis with a hedgehog pathway inhibitor
    Patent number: 12090127
    Abstract: Methods of treating a valvular heart disease are provided. Methods for treating valvular heard disease include administering to a subject a therapeutically effective amount of at least one hedgehog pathway inhibitor. Also provided are methods for reducing fibrosis in a subject, which comprise administering to the subject a therapeutically effective amount of at least one hedgehog pathway inhibitor.
    Type: Grant
    Filed: January 25, 2022
    Date of Patent: September 17, 2024
    Assignee: The Trustees of Indiana University
    Inventor: Jingwu Xie
  • METHODS FOR TREATING AORTIC VALVE STENOSIS WITH A HEDGEHOG PATHWAY INHIBITOR
    Publication number: 20220354832
    Abstract: Methods of treating a valvular heart disease are provided. Methods for treating valvular heard disease include administering to a subject a therapeutically effective amount of at least one hedgehog pathway inhibitor. Also provided are methods for reducing fibrosis in a subject, which comprise administering to the subject a therapeutically effective amount of at least one hedgehog pathway inhibitor.
    Type: Application
    Filed: January 25, 2022
    Publication date: November 10, 2022
    Applicant: The Trustees of Indiana University
    Inventor: Jingwu Xie
  • Methods for treating aortic valve stenosis with a hedgehog pathway inhibitor
    Patent number: 11154541
    Abstract: Methods of treating a valvular heart disease are provided. Methods for treating valvular heard disease include administering to a subject a therapeutically effective amount of at least one hedgehog pathway inhibitor. Also provided are methods for reducing fibrosis in a subject, which comprise administering to the subject a therapeutically effective amount of at least one hedgehog pathway inhibitor.
    Type: Grant
    Filed: June 28, 2019
    Date of Patent: October 26, 2021
    Assignee: The Trustees of Indiana University
    Inventor: Jingwu Xie
  • METHODS FOR TREATING AORTIC VALVE STENOSIS WITH A HEDGEHOG PATHWAY INHIBITOR
    Publication number: 20210315871
    Abstract: Methods of treating a valvular heart disease are provided. Methods for treating valvular heard disease include administering to a subject a therapeutically effective amount of at least one hedgehog pathway inhibitor. Also provided are methods for reducing fibrosis in a subject, which comprise administering to the subject a therapeutically effective amount of at least one hedgehog pathway inhibitor.
    Type: Application
    Filed: June 22, 2021
    Publication date: October 14, 2021
    Applicant: The Trustees of Indiana University
    Inventor: Jingwu Xie
  • MATERIALS AND METHODS FOR TREATING VALVULAR HEART DISEASES
    Publication number: 20200000784
    Abstract: Methods of treating a valvular heart disease are provided. Methods for treating valvular heard disease include administering to a subject a therapeutically effective amount of at least one hedgehog pathway inhibitor. Also provided are methods for reducing fibrosis in a subject, which comprise administering to the subject a therapeutically effective amount of at least one hedgehog pathway inhibitor.
    Type: Application
    Filed: June 28, 2019
    Publication date: January 2, 2020
    Applicant: The Trustees of Indiana University
    Inventor: Jingwu Xie
  • Cyclopamine tartrate salt and uses thereof
    Patent number: 8658664
    Abstract: The present invention provides compositions and methods for modulating smoothened-dependent pathway activation. The present invention provides highly water-soluble analogs of cyclopamine that are potent, hedgehog signaling inhibitors less toxic than cyclopamine. The compounds of the present invention are particularly useful in treating cancers associated with hedgehog signalling.
    Type: Grant
    Filed: August 9, 2010
    Date of Patent: February 25, 2014
    Assignee: The Board of Regents of the University of Texas System
    Inventors: Jingwu Xie, Massoud Garrossian
  • Hedgehog signaling pathway proteins and uses thereof
    Patent number: 8304399
    Abstract: The present invention discloses a component in the hedgehog signaling pathway that can be useful in the treatment and diagnosis of hedgehog signaling pathway associated disorders. In this regard, the present invention discloses that RanBPM regulated the stability of hedgehog signaling molecule, smoothened (SMO) and that inactivation of RanBPM by siRNA prevented growth and metastasis of cancer cells.
    Type: Grant
    Filed: November 9, 2007
    Date of Patent: November 6, 2012
    Assignee: The Board of Regents of the University of Texas System
    Inventors: Jingwu Xie, Tao Sheng, Xiaoli Zhang
  • Cyclopamine tartrate salt and uses thereof
    Publication number: 20110092530
    Abstract: The present invention provides compositions and methods for modulating smoothened-dependent pathway activation. The present invention provides highly water-soluble analogs of cyclopamine that are potent, hedgehog signaling inhibitors less toxic than cyclopamine. The compounds of the present invention are particularly useful in treating cancers associated with hedgehog signalling.
    Type: Application
    Filed: August 9, 2010
    Publication date: April 21, 2011
    Inventors: Jingwu Xie, Massoud Garrossian
  • HEDGEHOG SIGNALING PATHWAY PROTEINS AND USES THEREOF
    Publication number: 20100111955
    Abstract: The present invention discloses a component in the hedgehog signaling pathway that can be useful in the treatment and diagnosis of hedgehog signaling pathway associated disorders. In this regard, the present invention discloses that RanBPM regulated the stability of hedgehog signaling molecule, smoothened (SMO) and that inactivation of RanBPM by siRNA prevented growth and metastasis of cancer cells.
    Type: Application
    Filed: November 9, 2007
    Publication date: May 6, 2010
    Inventors: Jingwu Xie, Tao Sheng, Xiaoli Zhang
  • Regulation of the hedgehog signaling pathway and uses thereof
    Publication number: 20070059311
    Abstract: The present invention provides molecular mechanism leading to the development of cancers associated with hedgehog signaling pathway. These cancers may develop as a result of a chronic bacterial or a chronic viral infection. The present invention provides methods for early detection of such cancers. Additionally, it also provides measures that can be taken to prevent or treat such cancers.
    Type: Application
    Filed: September 12, 2006
    Publication date: March 15, 2007
    Inventor: Jingwu Xie