Patents by Inventor Jingxin Zhang

Jingxin Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10193173
    Abstract: A fuel cell stack hydrogen starvation detection device, a fuel cell system and a method of operating a fuel cell stack to protect it from hydrogen starvation conditions. In one particular form, the fuel cell system includes a stack of fuel cells, a controller and a detection device made up of one or more sensors that can compare a reference signal corresponding to the presence of substantially pure hydrogen to a signal that corresponds to a local hydrogen value within a single fuel cell within the stack or across multiple fuel cells within the stack. In this way, the detection device promptly provides indicia of a hydrogen starvation condition within the cell or stack without the need for conventional cell voltage monitoring. The detected hydrogen starvation condition may be presented as a warning signal to alert a user that such a condition may be present, as well as to the controller for modification of the stack operation.
    Type: Grant
    Filed: July 21, 2015
    Date of Patent: January 29, 2019
    Assignee: GM Global Technology Operations LLC
    Inventors: Jingxin Zhang, Balasubramanian Lakshmanan, Manish Sinha
  • Publication number: 20190008986
    Abstract: Among other things, the present disclosure relates to designed oligonucleotides, compositions, and methods thereof. In some embodiments, provided oligonucleotide compositions provide altered splicing of a transcript. In some embodiments, provided oligonucleotide compositions have low toxicity. In some embodiments, provided oligonucleotide compositions provide improved protein binding profiles. In some embodiments, provided oligonucleotide compositions have improved delivery. In some embodiments, provided oligonucleotide compositions have improved uptake. In some embodiments, the present disclosure provides methods for treatment of diseases using provided oligonucleotide compositions.
    Type: Application
    Filed: September 23, 2018
    Publication date: January 10, 2019
    Inventors: David Charles Donnell Butler, Sethumadhavan Divakaramenon, Christopher J. Francis, Maria David Frank-Kamenetsky, Naoki Iwamoto, Genliang Lu, Subramanian Marappan, Meena ., Chandra Vargeese, Gregory L. Verdine, Hailin Yang, Jason Jingxin Zhang
  • Patent number: 10158128
    Abstract: Disclosed are fuel cell stack break-in procedures, conditioning systems for performing break-in procedures, and motor vehicles with a fuel cell stack conditioned in accordance with disclosed break-in procedures. A break-in method is disclosed for conditioning a membrane assembly of a fuel cell stack. The method includes transmitting humidified hydrogen to the anode of the membrane assembly, and transmitting deionized water to the cathode of the membrane assembly. An electric current and voltage cycle are applied across the fuel cell stack while the fuel cell stack is operated in a hydrogen pumping mode until the fuel cell stack is determined to operate at a predetermined threshold for a fuel cell stack voltage output capability. During hydrogen pumping, the membrane assembly oxidizes the humidified hydrogen, transports protons from the anode to the cathode across the proton conducting membrane, and regenerates the protons in the cathode through a hydrogen evolution reaction.
    Type: Grant
    Filed: March 7, 2017
    Date of Patent: December 18, 2018
    Assignee: GM Global Technology Operations LLC
    Inventors: Jingxin Zhang, Nagappan Ramaswamy, Balasubramanian Lakshmanan, Swaminatha P. Kumaraguru
  • Publication number: 20180261858
    Abstract: Disclosed are fuel cell stack break-in procedures, conditioning systems for performing break-in procedures, and motor vehicles with a fuel cell stack conditioned in accordance with disclosed break-in procedures. A break-in method is disclosed for conditioning a membrane assembly of a fuel cell stack. The method includes transmitting humidified hydrogen to the anode of the membrane assembly, and transmitting deionized water to the cathode of the membrane assembly. An electric current and voltage cycle are applied across the fuel cell stack while the fuel cell stack is operated in a hydrogen pumping mode until the fuel cell stack is determined to operate at a predetermined threshold for a fuel cell stack voltage output capability. During hydrogen pumping, the membrane assembly oxidizes the humidified hydrogen, transports protons from the anode to the cathode across the proton conducting membrane, and regenerates the protons in the cathode through a hydrogen evolution reaction.
    Type: Application
    Filed: March 7, 2017
    Publication date: September 13, 2018
    Applicant: GM GLOBAL TECHNOLOGY OPERATIONS LLC
    Inventors: Jingxin Zhang, Nagappan Ramaswamy, Balasubramanian Lakshmanan, Swaminatha P. Kumaraguru
  • Patent number: 9899691
    Abstract: System and methods for detecting anode contamination in a fuel cell system are presented. In certain embodiments, a high frequency resistance response of a fuel cell system may be measured at a plurality of frequencies. In some embodiments, the rate of change of high frequency resistance response over time may differ at varied frequencies based on an amount of anode contamination in the fuel cell system. Accordingly, systems and methods disclosed herein may compare high frequency resistance responses taken at a plurality of measured frequencies to detect anode contamination and initiate associated recovery procedures in the fuel cell system.
    Type: Grant
    Filed: July 23, 2015
    Date of Patent: February 20, 2018
    Assignee: GM GLOBAL TECHNOLOGY OPERATIONS LLC
    Inventors: Donald H. Keskula, Mark P. Adams, Kenneth L. Kaye, Swaminatha P. Kumaraguru, Jingxin Zhang
  • Patent number: 9755244
    Abstract: A method for making corrosion resistant carbon nanoparticles includes a step of heating a carbon powder to a predetermined temperature. The carbon powder includes carbon particles having an average spatial dimension from about 10 to 100 nanometers. The carbon powder is contacted with a vapor of a metal-containing compound. The carbon powder is then contacted with a vapor of an activating compound. These steps are repeated plurality of times to form a metal-containing layer on the carbon particles.
    Type: Grant
    Filed: June 4, 2014
    Date of Patent: September 5, 2017
    Assignee: GM Global Technology Operations LLC
    Inventors: Balasubramanian Lakshmanan, Jingxin Zhang
  • Publication number: 20170125828
    Abstract: A method for reducing fuel cell voltage loss in a fuel cell that includes an anode catalyst layer including an anode catalyst and a cathode catalyst layer including a cathode catalyst with a proton exchange layer interposed between the anode catalyst layer and the cathode catalyst layer. The method includes a step of initiating shutdown of the fuel cell. Carbon monoxide or carbon monoxide-like species contaminating the anode catalyst is oxidized during shutdown such that carbon monoxide or carbon monoxide-like species is removed from the anode catalyst.
    Type: Application
    Filed: October 28, 2015
    Publication date: May 4, 2017
    Inventors: Jingxin ZHANG, Paul Taichiang YU, Balasubramanian LAKSHMANAN
  • Publication number: 20170117565
    Abstract: A fuel cell system that includes a component for removing anionic contaminants is provided. The fuel system including a fuel cell stack, a fuel gas feed subsystem in communication with fuel cell anodes in the fuel cell stack, an oxygen-containing gas feed subsystem system in communication with fuel cell cathodes in the fuel cell stack, and an anionic scavenging subsystem in communication with the fuel gas feed subsystem and/or the an oxygen-containing gas feed subsystem.
    Type: Application
    Filed: October 5, 2016
    Publication date: April 27, 2017
    Inventors: QIANG LI, PAUL TAICHIANG YU, JINGXIN ZHANG, BALASUBRAMANIAN LAKSHMANAN
  • Publication number: 20170062851
    Abstract: Systems and methods are disclosed that provide for a fuel cell stack assembly including stack end cells that facilitate improved diagnostic and detection capabilities. In certain embodiments, an anode side of a FC stack end cell consistent with embodiments disclosed herein may be configured to have a lower anode gas flow rate than other cells in the FC stack. The cathode side of a FC stack end cell consistent with embodiments disclosed herein may be further configured to have a higher gas flow rate than other cells in the FC stack. Embodiments of the disclosed FC stack end cells may, among other things, allow for detection of adverse conditions and/or events in a FC stack assembly prior to such conditions and/or events negatively affecting other cells in the FC stack.
    Type: Application
    Filed: April 24, 2015
    Publication date: March 2, 2017
    Inventors: MARK F. MATHIAS, JINGXIN ZHANG, BALASUBRAMANIAN LAKSHMANAN, MANISH SINHA
  • Publication number: 20170025693
    Abstract: System and methods for detecting anode contamination in a fuel cell system are presented. In certain embodiments, a high frequency resistance response of a fuel cell system may be measured at a plurality of frequencies. In some embodiments, the rate of change of high frequency resistance response over time may differ at varied frequencies based on an amount of anode contamination in the fuel cell system. Accordingly, systems and methods disclosed herein may compare high frequency resistance responses taken at a plurality of measured frequencies to detect anode contamination and initiate associated recovery procedures in the fuel cell system.
    Type: Application
    Filed: July 23, 2015
    Publication date: January 26, 2017
    Inventors: DONALD H. KESKULA, MARK P. ADAMS, KENNETH L. KAYE, SWAMINATHA P. KUMARAGURU, JINGXIN ZHANG
  • Publication number: 20170025692
    Abstract: A fuel cell stack hydrogen starvation detection device, a fuel cell system and a method of operating a fuel cell stack to protect it from hydrogen starvation conditions. In one particular form, the fuel cell system includes a stack of fuel cells, a controller and a detection device made up of one or more sensors that can compare a reference signal corresponding to the presence of substantially pure hydrogen to a signal that corresponds to a local hydrogen value within a single fuel cell within the stack or across multiple fuel cells within the stack. In this way, the detection device promptly provides indicia of a hydrogen starvation condition within the cell or stack without the need for conventional cell voltage monitoring. The detected hydrogen starvation condition may be presented as a warning signal to alert a user that such a condition may be present, as well as to the controller for modification of the stack operation.
    Type: Application
    Filed: July 21, 2015
    Publication date: January 26, 2017
    Inventors: Jingxin Zhang, Balasubramanian Lakshmanan, Manish Sinha
  • Patent number: 9337494
    Abstract: A fuel cell includes a first electrode and a second electrode with an ion conducting polymer membrane positioned between these electrodes. The fuel cell further comprises a first OER catalyst-containing ionic layer positioned between the first electrode and the ion conducting polymer membrane. The first OER catalyst-containing layer includes an OER catalyst-containing compound, an ion conducting polymer and carbon. Characteristically, the weight ratio of ion conducting polymer to carbon is from about 10 to about 100. A method for forming the fuel cell is also provided.
    Type: Grant
    Filed: January 12, 2009
    Date of Patent: May 10, 2016
    Assignee: GM GLOBAL TECHNOLOGY OPERATIONS LLC
    Inventors: Jingxin Zhang, Jeanette E. Owejan
  • Publication number: 20150357650
    Abstract: A method for making corrosion resistant carbon nanoparticles includes a step of heating a carbon powder to a predetermined temperature. The carbon powder includes carbon particles having an average spatial dimension from about 10 to 100 nanometers. The carbon powder is contacted with a vapor of a metal-containing compound. The carbon powder is then contacted with a vapor of an activating compound. These steps are repeated plurality of times to form a metal-containing layer on the carbon particles.
    Type: Application
    Filed: June 4, 2014
    Publication date: December 10, 2015
    Inventors: Balasubramanian LAKSHMANAN, Jingxin ZHANG
  • Publication number: 20150259426
    Abstract: The present invention relates to amino acid sequences that are directed against TRAIL cell surface receptor 2 (herein also “DR5”), as well as to compounds or constructs thereof, and in particular proteins and polypeptides and nucleotides that encode them (referred to herein in their entirety as “NB agents”) and fragments thereof, and pharmaceutically effective variants thereof, and their use in the diagnosis and treatment of DR5 associated diseases and disorders.
    Type: Application
    Filed: November 3, 2014
    Publication date: September 17, 2015
    Inventors: Karen CROMIE, Bruno DOMBRECHT, Seth ETTENBERG, Joost Alexander KOLKMAN, Jing LI, Kris MEERSCHAERT, Jingxin ZHANG
  • Patent number: 9120855
    Abstract: The present invention relates to amino acid sequences that are directed against TRAIL cell surface receptor 2 (herein also “DR5”), as well as to compounds or constructs thereof, and in particular proteins and polypeptides and nucleotides that encode them (referred to herein in their entirety as “NB agents”) and fragments thereof, and pharmaceutically effective variants thereof, and their use in the diagnosis and treatment of DR5 associated diseases and disorders.
    Type: Grant
    Filed: February 9, 2011
    Date of Patent: September 1, 2015
    Assignee: NOVARTIS AG
    Inventors: Karen Cromie, Bruno Dombrecht, Seth Ettenberg, Joost Kolkman, Jing Li, Kris Meerschaert, David Raymond Stover, Jingxin Zhang
  • Patent number: 8828613
    Abstract: Fuel-cell assemblies containing a membrane electrode assembly, methods for preparing the membrane electrode assembly, and methods for functionalizing catalytic surfaces of catalyst particles in the membrane electrode assembly of the fuel cell assembly have been described. The fuel-cell assemblies and their membrane electrode assemblies contain cathode catalyst materials having catalytic surfaces that are functionalized with cyano groups to improve catalyst activity. The cathode catalyst materials may include a catalytic metal such as platinum or a platinum alloy. The cyano groups may be derived from a cyanide source that is electro-oxidized onto the catalytic surfaces. Nonlimiting examples of cyanide sources include amino acids such as glycine, alanine, and serine.
    Type: Grant
    Filed: March 13, 2013
    Date of Patent: September 9, 2014
    Assignee: GM Global Technology Operations LLC
    Inventors: Jingxin Zhang, Rohit Makharia, Jeanette E. Owejan
  • Patent number: 8617770
    Abstract: One embodiment of the invention includes a method including providing a cathode catalyst ink comprising a first catalyst, an oxygen evolution reaction catalyst, and a solvent; and depositing the cathode catalyst ink on one of a polymer electrolyte membrane, a gas diffusion medium layer, or a decal backing.
    Type: Grant
    Filed: September 3, 2008
    Date of Patent: December 31, 2013
    Assignee: GM Global Technology Operations LLC
    Inventors: Susan G. Yan, Hubert A. Gasteiger, Paul Taichiang Yu, Wenbin Gu, Jingxin Zhang
  • Publication number: 20130260267
    Abstract: Fuel-cell assemblies containing a membrane electrode assembly, methods for preparing the membrane electrode assembly, and methods for functionalizing catalytic surfaces of catalyst particles in the membrane electrode assembly of the fuel cell assembly have been described. The fuel-cell assemblies and their membrane electrode assemblies contain cathode catalyst materials having catalytic surfaces that are functionalized with cyano groups to improve catalyst activity. The cathode catalyst materials may include a catalytic metal such as platinum or a platinum alloy. The cyano groups may be derived from a cyanide source that is electro-oxidized onto the catalytic surfaces. Nonlimiting examples of cyanide sources include amino acids such as glycine, alanine, and serine.
    Type: Application
    Filed: March 13, 2013
    Publication date: October 3, 2013
    Applicant: GM Global Technology Operations LLC
    Inventors: Jingxin Zhang, Rohit Makharia, Jeanette E. Owejan
  • Patent number: 8206872
    Abstract: An MEA for a fuel cell that employs multiple catalyst layers to reduce the hydrogen and/or oxygen partial pressure at the membrane so as to reduce the fluoride release rate from the membrane and reduce membrane degradation. An anode side multi-layer catalyst configuration is positioned at the anode side of the MEA membrane. The anode side multi-layer catalyst configuration includes an anode side under layer positioned against the membrane and including a catalyst, an anode side middle layer positioned against the anode side under layer and not including a catalyst and an anode side catalyst layer positioned against the anode side middle layer and opposite to the anode side under layer and including a catalyst, where the amount of catalyst in the anode side catalyst layer is greater than the amount of catalyst in the anode side under layer.
    Type: Grant
    Filed: July 26, 2007
    Date of Patent: June 26, 2012
    Assignee: GM Global Technology Operations LLC
    Inventors: Annette M. Brenner, Hubert A. Gasteiger, Wenbin Gu, James Leistra, Brian A. Litteer, Han Liu, Susan G. Yan, Jingxin Zhang
  • Publication number: 20110318366
    Abstract: The present invention relates to amino acid sequences that are directed against TRAIL cell surface receptor 2 (herein also “DR5”), as well as to compounds or constructs thereof, and in particular proteins and polypeptides and nucleotides that encode them (referred to herein in their entirety as “NB agents”) and fragments thereof, and pharmaceutically effective variants thereof, and their use in the diagnosis and treatment of DR5 associated diseases and disorders.
    Type: Application
    Filed: February 9, 2011
    Publication date: December 29, 2011
    Applicants: ABLYNX NV, NOVARTIS AG
    Inventors: Karen CROMIE, Bruno DOMBRECHT, Seth ETTENBERG, Joost KOLKMAN, Jing LI, Kris MEERSCHAERT, David Raymond STOVER, Jingxin ZHANG