Abstract: Provided are a class of pyrazolone compounds and a use thereof. In particular, a compound represented by formula I is provided, wherein the definition of each variable group is as described in the description. The compounds of formula (I) have a direct AMPK-activating activity and can significantly promote the phosphorylation of AMPK and ACC of L6 myocytes and HepG2 cells in a dose-dependent manner.

Abstract: The invention relates to a salt form of (R)-methyl-2-(3-aminopiperidin-1-yl)-3-(2-cyanobenzyl)-4-carbonyl-3,4-dihydrothiophene[3,2-d]pyrimidine-6-carboxylic acid and a preparation method for the salt form. Also disclosed is a pharmaceutical composition of the formula I compound salt form.

Abstract: According to certain embodiments, a method is disclosed for use in a wireless device that is transmitting uplink transmissions using a shortened transmission time interval (sTTI). The method comprises receiving control information from a network node. The control information indicates at least one index, and a beta-offset value is obtained based on the indicated index.

Abstract: C, O-spiro aryl glycoside compounds are provided. Specifically provided are C, O-spiro aryl glycoside compounds represented by the formula (I), wherein the definitions of each variable group are described in the specification. Also provided are methods of preparing and using the C, O-spiro aryl glycoside compounds. The C, O-spiro aryl glycoside compounds can be used as SGLT2 inhibitors and for treating diseases, such as diabetes, atherosclerosis, and adiposity.

Abstract: There is provided mechanisms for providing configuration for uplink transmission to a wireless device. A method is performed by a network node. The method comprises transmitting a message comprising configuration for uplink transmission with short TTI operation. The method comprises transmitting a fast grant comprising scheduling of an uplink short TTI for the wireless device.

Abstract: According to some embodiments, a method of synchronizing a wireless device with a network node comprises receiving a radio subframe transmitted from the network node. The radio subframe comprises a first Primary Synchronization Signal (PSS) associated with a first Orthogonal Frequency Division Multiplexing (OFDM) symbol and a first plurality of subcarriers. The first PSS is paired with a first Secondary Synchronization Signal (SSS) associated with a second OFDM symbol and the first plurality of subcarriers. The radio subframe also comprises a second PSS associated with the first OFDM symbol and a second plurality of subcarriers. The second PSS is paired with a second SSS associated with the second OFDM symbol and the second plurality of subcarriers. The method further comprises inspecting the first plurality of subcarriers to detect the first PSS and the first SSS and inspecting the second plurality of subcarriers to detect the second PSS and the second SSS.

Abstract: A method (110) in a user equipment (105;505) for transmitting a demodulation reference signal in a communications network (100). The method comprises determining (111) multiplexing information for the demodulation reference signal, and transmitting (113) the demodulation reference signal using the multiplexing information in a same time allocation as a demodulation reference signal of another user equipment. The method further comprises transmitting (115) data symbols associated with the demodulation reference signal in a separate time allocation of physical resources, and on a same physical frequency resource, to a time allocation of data symbols of the said another user equipment.

Abstract: It is presented a method performed by a network node of a wireless communication network for scheduling a wireless device in uplink. An uplink signal structure is configured to be used by the wireless device and the network node, wherein the uplink signal structure defines transmission subframes divided into symbol periods. The network node applies a short Transmission Time Interval, sTTI, scheduling interval, wherein each sTTI is shorter in time than a subframe and each sTTI comprises at least one symbol period. The method comprises: transmitting a control information message to the wireless device for an sTTI scheduling interval, the control information message comprising uplink scheduling information assigned to the wireless device, the uplink scheduling information indicating a position and a length for at least one of a reference signal and data in the uplink sTTI.

Abstract: The present invention relates to crystal form A of a compound. The present invention also discloses a preparation method and a pharmaceutical composition of the crystal form A. The crystal form A has strong hypoglycemic activity in vivo and is expected to be a novel pharmaceutically active ingredient for treating or preventing type II diabetes and/or complications of type II diabetes.

Abstract: The present invention relates to six-membered ring benzo derivatives as a DPP-4 inhibitor and a use thereof. In particular, the present invention relates to a compound as shown in formula I, a pharmaceutical composition containing the compound as shown in formula I and a use of the compound in the preparation of drugs for treating DPP-4 related diseases or inhibiting DPP-4.

Abstract: There is provided mechanisms for transmitting payload in a subframe. A method is performed by a first network device. The method comprises obtaining a transport block size (TBS) value by accessing an array storing a plurality of TBS values. The TBS value is proportional to number of user data symbols in a subframe of a given subframe length. One and the same array is accessed regardless of the given subframe length. The method comprises transmitting a physical channel carrying payload in the subframe to a second network device. The amount of data in the payload is determined by the TBS value.

Abstract: Provided are a class of pyrazolone compounds and a use thereof. In particular, a compound represented by formula I is provided, wherein the definition of each variable group is as described in the description. The compounds of formula (I) have a direct AMPK-activating activity and can significantly promote the phosphorylation of AMPK and ACC of L6 myocytes and HepG2 cells in a dose-dependent manner.

Abstract: According to some embodiments, a method of synchronizing a wireless device with a network node comprises receiving a radio subframe transmitted from the network node. The MBSFN radio subframe comprises a first Primary Synchronization Signal (PSS) associated with a first Orthogonal Frequency Division Multiplexing (OFDM) symbol and paired with a first Secondary Synchronization Signal (SSS) associated with a second OFDM symbol. The method further comprises detecting the first PSS and detecting the first SSS within the radio subframe. The method determines system information associated with the network node based on the detected PSS and SSS. The radio subframe is transmitted from the network node as a Multimedia Broadcast Multicast Services Single-Frequency Network (MBSFN) subframe.

Abstract: According to some embodiments, a method of synchronizing a wireless device with a network node comprises receiving a radio subframe transmitted from the network node. The radio subframe comprises a first Primary Synchronization Signal (PSS) associated with a first Orthogonal Frequency Division Multiplexing (OFDM) symbol and paired with a first Secondary Synchronization Signal (SSS) associated with a second OFDM symbol. The radio subframe also comprises a second PSS associated with a third OFDM symbol and paired with a second SSS associated with a fourth OFDM symbol. The method further comprises detecting at least one of the first PSS and the second PSS within the radio subframe and detecting at least one of the first SSS and the second SSS within the radio subframe. The method determines system information associated with the network node based on the detected at least one PSS and the detected at least one SSS.

Abstract: According to some embodiments, a method of synchronizing a wireless device with a network node comprises receiving a radio subframe transmitted from the network node. The radio subframe comprises a first Primary Synchronization Signal (PSS) associated with a first Orthogonal Frequency Division Multiplexing (OFDM) symbol and a first plurality of subcarriers. The first PSS is paired with a first Secondary Synchronization Signal (SSS) associated with a second OFDM symbol and the first plurality of subcarriers. The radio subframe also comprises a second PSS associated with the first OFDM symbol and a second plurality of subcarriers. The second PSS is paired with a second SSS associated with the second OFDM symbol and the second plurality of subcarriers. The method further comprises inspecting the first plurality of subcarriers to detect the first PSS and the first SSS and inspecting the second plurality of subcarriers to detect the second PSS and the second SSS.

Abstract: Disclosed are new thienyl [3,2-d] pyrimidin-4-one compounds shown as the general formula (I), preparation method, pharmaceutical compositions and pharmacological use thereof. The compounds are strong DPPIV (dipeptide peptidase IV) inhibitors and can treat type II diabetes through well inhibiting DPPIV indirectly increasing the content of GLP-1 in vivo and inducing a series of physiological actions in vivo. Therefore, the compounds could be developed as new promising drugs for treating diabetes.

Abstract: Novel bis-quinazoline derivatives as tyrosine kinase inhibitors, synthesis of these compounds, and novel methods for treating tyrosine kinase mediated diseases or disorders using these compounds are disclosed. In particular, the present invention provides tethered quinazoline derivative dimers as inhibitors to the epidermal growth factor receptor (EGFR) tyrosine kinase, pharmaceutical compositions thereof, and their therapeutic uses for treating EGFR kinase-mediated diseases or disorders, such as various cancers, as well as synthetic methods for preparing these novel compounds.

Abstract: Disclosed are new thienyl[3,2-d]pyrimidin-4-one compounds shown as the general formula (I), preparation method, pharmaceutical compositions and pharmacological use thereof. The compounds are strong DPPIV (dipeptide peptidase IV) inhibitors and can treat type II diabetes through well inhibiting DPPIV indirectly increasing the content of GLP-1 in vivo and inducing a series of physiological actions in vivo. Therefore, the compounds could be developed as new promising drugs for treating diabetes.

Abstract: Novel bis-quinazoline derivatives as tyrosine kinase inhibitors, synthesis of these compounds, and novel methods for treating tyrosine kinase mediated diseases or disorders using these compounds are disclosed. In particular, the present invention provides tethered quinazoline derivative dimers as inhibitors to the epidermal growth factor receptor (EGFR) tyrosine kinase, pharmaceutical compositions thereof, and their therapeutic uses for treating EGFR kinase-mediated diseases or disorders, such as various cancers, as well as synthetic methods for preparing these novel compounds.

Abstract: PTP1B inhibitors with the following structure (formula I). Experiments indicate that these inhibitors can effectively inhibit the activity of protein tyrosine phosphatase 1B (PTP1B). They can be used as insulin sensitisers. They can be used to prevent, delay or treat diseases which are related to insulin antagonism mediated by PTP1B, especially diabetes type II and obesity. The invention also provides methods for preparing these inhibitors.