Abstract: Extracellular protein degraders and compositions are provided that have a potent asialoglycoprotein receptor (ASGPR) Binding Ligand bound to an Extracellular Protein Targeting Ligand for the selective degradation of the Target Extracellular Protein, for example immunoglobulin in vivo to treat disorders mediated by the extracellular protein.

Abstract: Compounds and compositions that have an asialoglycoprotein receptor (ASGPR) binding ligand bound to an extracellular protein binding ligand for the selective degradation of the target extracellular protein in vivo to treat disorders mediated by the extracellular protein are described.

Abstract: Extracellular protein degraders and compositions are provided that have a potent asialoglycoprotein receptor (ASGPR) Binding Ligand bound to an Extracellular Protein Targeting Ligand for the selective degradation of the Target Extracellular Protein, for example immunoglobulin in vivo to treat disorders mediated by the extracellular protein.

Abstract: Compounds and compositions that have an asialoglycoprotein receptor (ASGPR) binding ligand bound to an extracellular protein binding ligand for the selective degradation of the target extracellular protein in vivo to treat disorders mediated by the extracellular protein are described.

Abstract: Compounds and compositions that have an asialoglycoprotein receptor (ASGPR) binding ligand bound to an extracellular protein binding ligand for the selective degradation of the target extracellular protein in vivo to treat disorders mediated by the extracellular protein are described.

Abstract: Compounds and compositions that have an asialoglycoprotein receptor (ASGPR) binding ligand bound to an extracellular protein binding ligand for the selective degradation of the target extracellular protein in vivo to treat disorders mediated by the extracellular protein are described.

Abstract: Compounds and compositions that have an asialoglycoprotein receptor (ASGPR) binding ligand bound to an extracellular protein binding ligand for the selective degradation of the target extracellular protein in vivo to treat disorders mediated by the extracellular protein are described.

Abstract: Compounds and compositions that have an asialoglycoprotein receptor (ASGPR) binding ligand bound to an extracellular protein binding ligand for the selective degradation of the target extracellular protein in vivo to treat disorders mediated by the extracellular protein are described.

Abstract: Extracellular protein degraders and compositions are provided that have a potent asialoglycoprotein receptor (ASGPR) Binding Ligand bound to an Extracellular Protein Targeting Ligand for the selective degradation of the Target Extracellular Protein, for example immunoglobulin in vivo to treat disorders mediated by the extracellular protein.

Abstract: Compounds and compositions that have an asialoglycoprotein receptor (ASGPR) binding ligand bound to an extracellular protein binding ligand for the selective degradation of the target extracellular protein in vivo to treat disorders mediated by the extracellular protein are described.

Abstract: Extracellular protein degraders and compositions are provided that have a potent asialoglycoprotein receptor (ASGPR) Binding Ligand bound to an Extracellular Protein Targeting Ligand for the selective degradation of the Target Extracellular Protein, for example immunoglobulin in vivo to treat disorders mediated by the extracellular protein.

Abstract: Compounds and compositions that have an asialoglycoprotein receptor (ASGPR) binding ligand bound to an extracellular protein binding ligand for the selective degradation of the target extracellular protein in vivo to treat disorders mediated by the extracellular protein are described.

Abstract: Extracellular protein degraders and compositions are provided that have a potent asialoglycoprotein receptor (ASGPR) Binding Ligand bound to an Extracellular Protein Targeting Ligand for the selective degradation of the Target Extracellular Protein, for example immunoglobulin in vivo to treat disorders mediated by the extracellular protein.

Abstract: Compounds and compositions that have an asialoglycoprotein receptor (ASGPR) binding ligand bound to an extracellular protein binding ligand for the selective degradation of the target extracellular protein in vivo to treat disorders mediated by the extracellular protein are described.

Abstract: Compounds and compositions that have an asialoglycoprotein receptor (ASGPR) binding ligand bound to an extracellular protein binding ligand for the selective degradation of the target extracellular protein in vivo to treat disorders mediated by the extracellular protein are described.

Abstract: Compounds and compositions that have an asialoglycoprotein receptor (ASGPR) binding ligand bound to an extracellular protein binding ligand for the selective degradation of the target extracellular protein in vivo to treat disorders mediated by the extracellular protein are described.

Abstract: A system and method for audio splicing (insertion) of an Ad audio stream in the compressed domain, where variable early delivery of the Ad audio stream and variable bit rate are allowed, without creating audio distortion, glitches, or other digital artefacts or errors, in the resultant audio stream is disclosed. The present system and method provides for a splice delay buffer which delays the first five Ad audio frames until transmission of the last frame of the primary audio stream, but before the splice time. Subsequent Ad audio frames are delayed by a fixed amount, where the fixed amount is greater than the frame delay of the primary audio stream, to allow for ease of splice back to the primary audio stream.

Abstract: A system and method for audio splicing (insertion) of an Ad audio stream in the compressed domain, where variable early delivery of the Ad audio stream and variable bit rate are allowed, without creating audio distortion, glitches, or other digital artefacts or errors, in the resultant audio stream is disclosed. The present system and method provides for a splice delay buffer which delays the first five Ad audio frames until transmission of the last frame of the primary audio stream, but before the splice time. Subsequent Ad audio frames are delayed by a fixed amount, where the fixed amount is greater than the frame delay of the primary audio stream, to allow for ease of splice back to the primary audio stream.

Abstract: A controller allocates a bit size for a current frame in a group of pictures of a first compression-encoded digital video signal that is to be spliced following transmission of the group of pictures with a second compression-encoded digital video signal. The signals are spliced after a predetermined switching time. The spliced signals are buffered by a decoder buffer and then decoded by a decoder. When the second signal has a variable bit-encoding rate and the current frame is not decoded until after the predetermined switching time, the maximum bit size is determined in accordance with an estimate of the decoder buffer fullness at the predetermined switching time. When the second signal has a predetermined maximum variable bit-encoding rate and the current frame is not decoded until after the predetermined switching time, the minimum bit size is determined in accordance with the predetermined maximum bit-encoding rate of the second signal.

Abstract: A controller allocates a bit size for a current frame in a group of pictures of a first compression-encoded digital video signal that is to be spliced following transmission of the group of pictures with a second compression-encoded digital video signal. The signals are spliced after a predetermined switching time. The spliced signals are buffered by a decoder buffer and then decoded by a decoder. When the second signal has a variable bit-encoding rate and the current frame is not decoded until after the predetermined switching time, the maximum bit size is determined in accordance with an estimate of the decoder buffer fullness at the predetermined switching time. When the second signal has a predetermined maximum variable bit-encoding rate and the current frame is not decoded until after the predetermined switching time, the minimum bit size is determined in accordance with the predetermined maximum bit-encoding rate of the second signal.