Abstract: An anti-MASP2 antibody, an antigen-binding fragment thereof and the medical use thereof. Specifically, provided are an anti-MASP2 antibody or an antigen-binding fragment thereof, a pharmaceutical composition thereof, a method for treating diseases such as IgA nephropathy and a related pharmaceutical use.

Abstract: A drug conjugate of a glucocorticoid receptor agonist, and an application thereof in medicine. Specifically, the present invention relates to an antibody-drug conjugate as represented by formula (I): Ab-(L-D)k (I), wherein Ab is an antibody or an antigen-binding fragment thereof, L is a linker covalently linking Ab to D, k is 1 to 20, and D is as represented by formula (II-A) or (II-B). The groups in the formulas are as defined in the description. The antibody-drug conjugate can effectively treat autoimmune diseases.

Abstract: A computer-program product storing instructions which, when executed by a computer, cause the computer to receive an input data from a sensor, generate a training data set utilizing the input data, wherein the training data set is created by creating one or more copies of the input data and adding noise to the one or more copies, send the training data set to a diffusion model, wherein the diffusion model is configured to reconstruct and purify the training data set by removing noise associated with the input data and reconstructing the one or more copies of the training data set to create a modified input data set, send the modified input data set to a fixed classifier, and output a classification associated with the input data in response to a majority vote of the classification obtained by the fixed classifier of the modified input data set.

Abstract: Provided is an application of a JAK inhibitor in kidney disease. Specifically, provided is a use of a JAK inhibitor in the preparation of a drug for treating or preventing kidney disease.

Abstract: The present invention provides a metal-carbon composite of a core-shell structure and a method of synthesizing the same. The method includes preparing a first polymer-covered glass substrate with a nano-thickness metal film deposited thereon; immersing the first polymer-covered glass substrate with the metal film to delaminate one or more 2D freestanding organic-metal nanosheets from the first polymer-covered glass substrate; transferring the one or more 2D freestanding organic-metal nanosheets onto a second target substrate; and annealing the one or more 2D freestanding organic-metal nanosheets to decompose an organic portion of the organic-metal nanosheet into an amorphous carbon-containing shell forming a metal-carbon nanocomposite of a core-shell structure.

Abstract: The present invention provides a metal-carbon composite of a core-shell structure and a method of synthesizing the same. The method includes preparing a first polymer-covered glass substrate with a nano-thickness metal film deposited thereon; immersing the first polymer-covered glass substrate with the metal film to delaminate one or more 2D freestanding organic-metal nanosheets from the first polymer-covered glass substrate; transferring the one or more 2D freestanding organic-metal nanosheets onto a second target substrate; and annealing the one or more 2D freestanding organic-metal nanosheets to decompose an organic portion of the organic-metal nanosheet into an amorphous carbon-containing shell forming a metal-carbon nanocomposite of a core-shell structure.

Abstract: The present invention relates to a method for preparing a nanosheet including the steps of: depositing a solution onto a substrate to form a first layer, wherein the substrate is rotatable relative to the depositing solution; depositing and condensing target material onto the first layer to form a second layer; and separating the second layer from the first layer and the substrate to form a nanosheet. Also disclosed a multilayer structure including: a substrate; a first layer arranged to deposit onto the substrate, wherein the substrate is rotatable relative to the depositing of the first layer; and a second layer arranged to deposit onto the first layer and separable from the first layer to form a nanosheet.

Abstract: The present invention relates to a semiconductor manufacturing method, a mask forming method and a semiconductor structure. According to one aspect of the invention, a semiconductor manufacturing method is provided, comprising: forming a metal wiring layer on a semiconductor substrate, the metal wiring layer comprising dielectrics and metal wires and metal FILLs within the dielectrics; removing the metal FILLs in the metal wiring layer completely to form the metal wiring layer without the metal FILLs. With the technical solution according to embodiments of the invention, undesirable influences due to metal FILLs will be eliminated.

Abstract: The present invention relates to a semiconductor manufacturing method, a mask forming method and a semiconductor structure. According to one aspect of the invention, a semiconductor manufacturing method is provided, comprising: forming a metal wiring layer on a semiconductor substrate, the metal wiring layer comprising dielectrics and metal wires and metal FILLs within the dielectrics; removing the metal FILLs in the metal wiring layer completely to form the metal wiring layer without the metal FILLs. With the technical solution according to embodiments of the invention, undesirable influences due to metal FILLs will be eliminated.