Patents by Inventor Jingyang Zhu

Jingyang Zhu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Processes for the production of &agr;-difluoromethyl ornithine (DFMO)
    Patent number: 6730809
    Abstract: Provided are processes and synthetic intermediates useful for the preparation of &agr;-difluoromethylornithine (DFMO) having the formula
    Type: Grant
    Filed: August 19, 2002
    Date of Patent: May 4, 2004
    Assignee: Women First Healthcare, Inc.
    Inventors: Jingyang Zhu, Scott T. Chadwick, Benjamin A. Price, Shannon X. Zhao, Carrie A. Costello, Purushotham Vemishetti
  • Enzymatic resolution of aryl and thio-substituted acids
    Publication number: 20040077061
    Abstract: Provided is a method of resolving a racemic mixture of a compound of formula I to obtain a desired enantiomer: 1
    Type: Application
    Filed: July 23, 2003
    Publication date: April 22, 2004
    Inventors: Jingyang Zhu, Shannon X. Zhao
  • Enzymatic resolution of aryl and thio-substituted acids
    Publication number: 20040072310
    Abstract: Provided is a method of resolving a racemic mixture of a compound of formula I to obtain a desired enantiomer: 1
    Type: Application
    Filed: July 23, 2003
    Publication date: April 15, 2004
    Inventors: Jingyang Zhu, Li You, Brenda J. White, Shannon X. Zha, Paul M. Skonezny
  • Enzymatic resolution of aryl and thio-substituted acids
    Patent number: 6620600
    Abstract: Provided is a method of resolving a racemic mixture of a compound of formula I to obtain a desired enantiomer: wherein Ar is C6 or C10 aromatic group that can be substituted with H, C1 to C6 alkyl, trifluoromethyl or halo, R5 is halo or —S—R1, wherein R1 is H or acetyl, and R2 is H or C1 to C6 alkyl, the method comprising: reacting a compound of formula I wherein the compound is an ester whereby R2 is C1 to C6 alkyl with a lipase derived from Mucor meihei to stereoselectively hydrolyze the ester bond to produce an acid; and isolating the acid, wherein the reaction is conducted in a solvent comprising 80% to 98% v/v % organic phase and a residue of water phase (which can be buffered).
    Type: Grant
    Filed: September 5, 2001
    Date of Patent: September 16, 2003
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Jingyang Zhu, Li You, Brenda J. White, Shannon X. Zhao, Paul M. Skonezny
  • Processes for the production of alpha-difluoromethyl ornithine (DFMO)
    Publication number: 20030083384
    Abstract: Provided are processes and synthetic intermediates useful for the preparation of &agr;-difluoromethylornithine (DFMO) having the formula 1
    Type: Application
    Filed: August 19, 2002
    Publication date: May 1, 2003
    Applicant: Bristol-Myers Squibb Company to Women First HealthCare, Inc.
    Inventors: Jingyang Zhu, Scott T. Chadwick, Benjamin A. Price, Shannon X. Zhao, Carrie A. Costello, Purushotham Vemishetti
  • Dynamic resolution of isomers and resolved isomers
    Publication number: 20020111512
    Abstract: Provided is a dynamic resolution method of enriching a desired isomer of an alpha-substituted carboxylic acid relative to an undesired isomer, the method comprising: (a) in a solvent, contacting the alpha-substituted carboxylic acid, wherein the alpha substitution is with a leaving group and wherein the alpha carbon is chiral, with a homochiral amine to form a salt that is partially insoluble under selected reaction conditions, wherein the homochiral amine is selected so that the solubility of the amine salt of the undesired alpha-substituted carboxylic acid is greater than that of the amine salt of the desired alpha-substituted carboxylic acid under the selected reaction conditions; (b) reacting under the selected reaction conditions the salt with a nucleophile, wherein the reacting is effective in producing a net increase in the less soluble amine salt of the alpha-substituted carboxylic acid, and wherein the selected conditions are selected to (i) promote nucleophilic substitution of the nucleophile and th
    Type: Application
    Filed: September 24, 2001
    Publication date: August 15, 2002
    Inventors: John J. Venit, Gary D. Madding, Victor W. Rosso, Francis J. Okuniewicz, Robert P. Discordia, Susanne Kiau, Atul S. Kotnis, Michael E. Randazzo, D. David Hennings, Jingyang Zhu, Jason G. Chen
  • Enzymatic resolution of aryl and thio-substituted acids
    Publication number: 20020061565
    Abstract: Provided is a method of resolving a racemic mixture of a compound of formula I to obtain a desired enantiomer: 1
    Type: Application
    Filed: September 5, 2001
    Publication date: May 23, 2002
    Inventors: Jingyang Zhu, Li You, Brenda J. White, Shannon X. Zhao, Paul M. Skonezny