Abstract: The present disclosure relates to an injectable lurasidone suspension and a preparation method thereof, and in particular to an irregular form of a lurasidone solid and a pharmaceutical composition thereof. The present disclosure also relates to a preparation method for the solid and the pharmaceutical composition thereof, and an application thereof in the treatment of mental diseases. According to the present disclosure, the lurasidone solid prepared has controllable particle size and has Dv5O particle size of 6 ?m to 110 ?m. The good particle size stability can also he maintained in the pharmaceutical composition. The lurasidone suspension preparation obtained by the method is fast-acting, has a long sustained release period, and can effectively reduce the risk caused by poor patient compliance.

Abstract: A pixel circuit and a driving method therefor and a display panel are provided. The pixel circuit includes a driving circuit, a data writing circuit, a storage circuit, and a first reset circuit; the driving circuit includes a control terminal, a first terminal, and a second terminal, and is configured to control a driving current flowing through the first terminal and the second terminal for driving a light-emitting element to emit light; the data write circuit is configured to write a data signal into the control terminal of the driving circuit; the storage circuit is configured to store the data signal; the first reset circuit is configured to apply a first initialization voltage to the control terminal of the driving circuit; the driving circuit and the data write circuit each include an N-type thin film transistor; and the first reset circuit includes an N-type oxide thin film transistor.

Abstract: A method and apparatus for hydrocracking mineralized refuse pyrolysis oil. The method may use the following steps: (a) crushing and pyrolyzing mineralized refuse to obtain arene and alkane precursor biomass oil; (b) hydrogenating the arene and alkane precursor biomass oil obtained in step (a), and separating the obtained hydrocrackate to obtain arene and alkane; and (c) purifying, recovering and optimizing the arene and alkane obtained in step (b), and performing deep processing to produce naphtha, jet fuel, light diesel oil, and heavy diesel oil.

Abstract: The present disclosure discloses a method for automatically identifying south troughs by improved Laplace and relates to the technical field of meteorology. The method includes the following steps: acquiring grid data of a geopotential height field; calculating a gradient field of the geopotential height field in an x direction; searching for a turning point where a gradient value turned from being negative to being positive, and cleaning the gradient field; calculating a divergence of the x direction to obtain an improved Laplacian numerical value L?; performing 0,1 binarization processing on the L? to obtain a black-and-white image and a plurality of targets of potential troughs, merging the black-and-white image and the plurality of targets of the potential troughs by expansion, recovering original scale through erosion, and selecting an effective target through an angle of direction of a contour and an axial ratio.

Abstract: A method of extracting myricetin from Xanthoceras sorbifolia Bunge is provided. The method includes: step 1, baking obtaining Xanthoceras sorbifolia Bunge crude powder; step 2, mixing the crude powder with a counter-current extraction solution to perform a counter-current extraction to obtain a filtrate and a filter residue; step 3, mixing the filter residue with a solvent to obtain a first mixture, and heating the first mixture to reflux for extraction to obtain an extraction liquid; step 4, mixing the extraction liquid and the filtrate, and concentrating under reduced pressure to obtain a concentrated solution; and step 5, separating and eluting the concentrated solution to obtain an eluent, then drying the eluent to obtain the myricetin.

Abstract: The present invention relates to application of gossypol and its optical isomers to preparation of an anti-Coronavirus drug. Specifically disclosed is application of pharmaceutically acceptable salts, solvates, isotopes, stereoisomers, stereoisomer mixtures, and tautomers of the gossypol and its optical isomers to preparation of a drug for preventing and/or treating a disease caused by a Coronavirus. The Coronavirus is MERS-CoV, SARS-CoV, or SARS-CoV-2. It is found in the present invention for the first time that the gossypol and its optical isomers can inhibit the activity of Coronavirus 3CL proteases to achieve an anti-Coronavirus effect. The half maximal inhibitory concentrations of gossypol and (?)-gossypol to SARS-CoV proteases and SARS-CoV-2 3CL proteases are all lower than 10 ?M. The anti-Coronavirus 3CL protease effect is good. Therefore, the gossypol and its optical isomers have the potential for use in the preparation of a drug for preventing and/or treating novel Coronavirus infections.

Abstract: The disclosure relates to the technical field of extraction of an active ingredient from traditional Chinese medicine, and provides a method of extracting myricetin from Xanthoceras sorbifolia Bunge.

Abstract: Systems and methods for determining collusion in student academic exams are described. One embodiment includes receiving an input electronic file with academic test data that includes student identifiers, question scores associated with each student identifier, and the total score for each student, calculating an identity score for each pair of students, determining a maximum identity score for each student, generating a normalized collusion score for each student by subtracting from the maximum identity score an average identity score to generate an identity metric, and dividing the identity metric by a local average identity metric to generate a normalized collusion score, where the local average identity metric is an estimated average of a set of identity metrics for a subset of students adjacent to one another on the total test score ranked list, writing student identifiers and normalized collusion scores associated with student identifiers to an output electronic file.

Abstract: A pleuromutilin cinnamic acid ester compound with activities against antibiotic-resistant infections having the following formula (I) R1, R2, R3, R4 and R5 are independently hydrogen, halogen, nitro, cyano, methoxy, trifluoromethyl, benzyloxy, aryl or dimethylamino.

Abstract: A method for analyzing disaster prevention and mitigation effectiveness of an ecological seawall is provided, including: performing seawall ecologicalization on a target seawall; establishing three-dimensional space hydrodynamic force for the target ecological seawall; simulating wave climbing on a dike body and a wave overtopping on a dike top of the target ecological seawall to obtain a wave overtopping index; calculating wave-flow bottom shear stress of the target ecological seawall, establishing a sediment movement model, and calculating suspended load and bed load sediment transportation volumes; calculating the change index of coastal bed surface according to the suspended load and bed load sediment transportation volumes, and determining a development index of tidal flats in front of dike of the target ecological seawall according to the change index; and calculating the disaster prevention and mitigation effectiveness grade of the target ecological seawall according to the wave overtopping index and t

Abstract: The present invention relates to the technical field of medicinal chemistry, and particularly to a method for preparing a 3-tetrazolylmethyl-1,3,5-triazin-2,4-dione compound inhibiting coronavirus 3CL protease activity and use thereof. Specifically, a compound of Formula I, or a pharmaceutically acceptable salt, or an optical isomer, or an isotope-substituted form thereof is provided. The compound effectively inhibits the SARS-CoV-2 3CLpro activity, and is useful in the preparation of a SARS-CoV-2 3CLpro inhibitor to block the replication and transcription of SARS-CoV-2 viruses in patients. The compound prepared in the present invention has high in-vitro safety, and very good prospect of application in the preparation of SARS-CoV-2 3CLpro inhibitors and anti-SARS-CoV-2 drugs.

Abstract: A portable electronic device may include a housing, a display at least partially within the housing, a transparent cover over the display, and a battery at least partially within the housing. The battery may include a battery cell, a pouch encasing the battery cell, and a gas release relief system including a gas-permeable membrane configured to prevent liquid from escaping the pouch and a valve configured to selectively release gas from the pouch. The device may also include a processing system configured to, in a first mode of operation, cause the valve to open to allow gas to be released from the pouch, and, in a second mode of operation, cause the valve to close.

Abstract: The present invention discloses a pleuromutilin derivative containing thiazole-pyridine benzyl quaternary ammonium salt side chain and a preparation method and use thereof and belongs to the field of medicinal chemistry. A pleuromutilin derivative with thiazole-pyridine benzyl quaternary ammonium salt side chain is successfully prepared by structural reconstruction of pleuromutilin and then structural modification with a quaternary ammonium salt compound. This compound synthesis method has the advantages of easily available raw materials, simple operation and high product yield, and is suitable for industrial production. The results of in vitro pharmacological experiments show that the pleuromutilin derivative of the present invention have good antibacterial and anti-mycoplasma activities, as well as good solubility, and these results show that the pleuromutilin derivative is of great value in the development of an anti-pathogenic microorganism drug.

Abstract: Described herein are fusion proteins including methanol dehydrogenase (MeDH) and at least one other polypeptide such as 3-hexulose-6-phosphate dehydrogenase (HPS) or 6-phospho-3-hexuloisomerase (PHI), such as DHAS synthase or fructose-6-Phosphate aldolase or such as DHA synthase or DHA kinase. In a localized manner, the fusion protein can promote the conversion of methanol to formaldehyde and then to a ketose phosphate such as hexulose 6-phosphate or then to DHA and G3P. When expressed in cells, the fusion proteins can promote methanol uptake and rapid conversion to the ketose phosphate or to the DHA and D3P, which in turn can be used in a pathway for the production of a desired bioproduct. Beneficially, the rapid conversion to the ketose phosphate or to the DHA and G3P can avoid the undesirable accumulation of formaldehyde in the cell.

Abstract: A Syringa microphylla seed extract includes the following components by weight based on a total weight of the Syringa microphylla seed extract: 0.4944-0.7142 mg/g of echinacoside, 6.624-7.617 mg/g of oleuropein, 0.4276-0.6309 mg/g of verbascoside, 3.927-4.684 mg/g of syringin, and 4.505-5.250 mg/g of forsythiaside B. A method of preparing the Syringa microphylla seed extract is disclosed. A composition for treating antibiotic-resistant infections that includes the Syringa microphylla seed extract is also disclosed.

Abstract: A pleuromutilin cinnamic acid ester compound with activities against antibiotic-resistant infections having the following formula (I) R1, R2, R3, R4 and R5 are independently hydrogen, halogen, nitro, cyano, methoxy, trifluoromethyl, benzyloxy, aryl or dimethylamino.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for debugging an application are provided. In some aspects, a method includes detecting rendering of a digital component by an application executing on the device. A first signals indicative of visible attributes of content assets of the test digital component and second signals indicative of hierarchical associations between the content assets as rendered are obtained. A validation process the compares the first signals and the second signals to a set of requirements is invoked. A determination is made that one or more requirements are not met by the first signals or the second signals. In response to determining that the one or more requirements are not met a non-compliant overlay is provided within the application indicating that the digital component fails to comply with the one or more requirements.

Abstract: Described herein are non-natural NAD+-dependent alcohol dehydrogenases (ADHs) capable of at least two fold greater conversion of methanol or ethanol to formaldehyde or acetaldehyde, respectively, as compared to its unmodified counterpart. Nucleic acids encoding the non-natural alcohol dehydrogenases, as well as expression constructs including the nucleic acids, and engineered cells comprising the nucleic acids or expression constructs are described. Also described are engineered cells expressing a non-natural NAD+-dependent alcohol dehydrogenase, optionally include one or more additional metabolic pathway transgene(s), methanol metabolic pathway genes, target product pathway genes, cell culture compositions including the cells, methods for promoting production of the target product or intermediate thereof from the cells, compositions including the target product or intermediate, and products made from the target product or intermediate.

Abstract: A method of preparing a hydroxytyrosol sturgeon skin gelatin film with antioxidant activity and Salmonella detection ability includes: (1) mixing a neutral red indicator solution and distilled water at room temperature to obtain a mixture solution, and adding 1 mol/L NaHCO3 solution to the mixture solution until discoloration to obtain an alkaline solution; (2) adding an amount of the alkaline solution obtained in step (1) to a mixture of Sturgeon skin gelatin and distilled water to obtain an alkaline gelatin solution; (3) adding hydroxytyrosol and glycerin and propylene glycol to the alkaline gelatin solution to obtain a hydroxytyrosol gelatin solution, and heating the hydroxytyrosol gelatin solution at 40-70° C.; (4) ultrasonicating the hydroxytyrosol gelatin solution from step (3), placing the hydroxytyrol gelatin solution evenly on a clean plexiglass plate, drying the hydroxytyrol gelatin solution on an ultra-clean worktable to obtain the hydroxytyrosol sturgeon skin gelatin film.

Abstract: A method of preparing a Paris polyphylla saponin extract includes: (1) adding Paris polyphylla saponin in 60-90% ethanol to obtain a mixture, heating the mixture under reflux for 2-4 hours; (2) concentrating the mixture to ¼ volume, centrifuging the mixture to obtain a supernatant A and a precipitate A, adding the precipitate A to 60-80% ethanol to obtain a supernatant B and a precipitate B, washing the precipitate B with water and petroleum ether and drying; and (3) combining the supernatant A and the supernatant B, mixing with a macroporous adsorption resin, loading to a chromatography column, eluting the chromatography column with water and 80-90% ethanol, collecting an ethanol eluent, concentrating the ethanol eluent to obtain an eluent extract, and combining the eluent extract and the precipitate B and drying to obtain the Paris polyphylla saponin extract.