Abstract: The invention provides a novel class of therapeutic agents that are safe and effective TYK2 inhibitors and pharmaceutical compositions of these compounds and methods of preparation and use thereof against various TYK2-mediated diseases and disorders.

Abstract: An ultrasonic probe holder includes a probe holder frame, an arc plate, a follower plate, and a plurality of contacts. The frame can have at least one aperture extending therethrough, open in the downward direction, and defining an open lower end of the frame. The arc plate can be positioned within the aperture, extend between opposed, curved lateral edges, and couple to the frame. The follower plate can be mounted to a lower end of the arc plate and include arms extending laterally outward from a vertical axis in the plane of the arc plate. The contacts can be slidably mounted to the arms of the follower plate and extend in the vertical direction. The arc plate can be constrained in the plane of the frame and to pivot with respect to the frame in response to vertical movement of one or more of the plurality of contacts.

Abstract: The embodiment of the present disclosure discloses a method, an electronic device, and a storage medium for a ship route optimization. The method for the ship route optimization considers a dynamic feature of a multi-functional emergency rescue ship and an interference effect caused by an airflow, uses a movement model with kinematics non-holonomic constraints, such as a ship total cost assessment function to simulate the movement of the ship, and based on a sparrow search algorithm, learns how to apply the algorithm to a route plan of the emergency rescue ship. The method can improve the ship route optimization algorithm, improve an accuracy and practical applicability of a calculated plan. The method can effectively and accurately locate obstacles and hidden reefs, and consider effects of an airflow and a non-holonomic constraint effect, so as to make the route planning of the ship more efficient and intelligent.

Abstract: A license plate classification method, a license plate classification apparatus and a computer-readable storage medium are provided. The method includes: performing a license plate recognition process on a first license plate image to obtain a license plate recognition result; performing an encoding process on the license plate recognition result to obtain a first license plate feature; performing a feature extraction process on the first license plate image to obtain a second license plate feature; and processing the first license plate feature and the second license plate feature through a classification network to obtain a first license plate classification result. In this way, an accuracy of license plate classification is improved.

Abstract: A traffic information quantization method in an intelligent network environment includes: step S1: extracting traffic information sources according to collected videos and classifying the traffic information sources; step S2: obtaining a state set and a probability distribution of each traffic information source through actual observation and calculation; step S3: using information theory to quantify the traffic information sources. Further, a traffic information quantization system in the intelligent network environment is provided, and the traffic information quantization method in the intelligent network environment and its system are adopted to quantify the driving information of the driving process and calculate the amount of information. The method and system can transform uncertain information into certain information, improve driving efficiency, help drivers optimize the driving process, and ensure driving safety.

Abstract: A method suitable for driver takeover training of man-machine shared driving vehicle relates to the field of man-machine shared driving technology. The method includes: establishing database, situation-creation, establish a teaching model, take over training, evaluation and analysis of takeover ability. The method divides the driver's takeover behavior into a small operation action through the driver takeover training of the man-machine shared driving vehicle, defines where the driver's eyes need to observe when the takeover reminder appears, how the hands and feet need to be operated, and the sequence of these operations, solves the problems of the driver's tension and being in a flurry in the current sudden takeover reminder. In addition, through the evaluation and analysis of the takeover capability, the method can solve the problem that the existing technology cannot objectively evaluate the driver's takeover capability level.

Abstract: The present invention provides a novel method for determining a long-chain non-coding ribonucleic acid interaction protein. The present invention provides a fusion protein formed by BASU and dCasRx, a mammalian expression vector for expressing said fusion protein. The method for determining the lncRNA interaction protein according to the present invention comprises: co-transfecting a mammalian expression vector that expresses the fusion protein and a gRNA that specifically targets the target lncRNA into target cells, thereby BASU specifically biotin-labeling effector proteins nearby; isolating the biotinylated proteins by using a streptavidin affinity coupled magnetic bead and then eluting, and digesting by trypsin and quantitatively analyzing by a label-free mass spectrometry. The present invention can highly credibly determine the proteins that interact with lncRNA.

Abstract: A power supply system for an electric vehicle includes: a battery system including one battery pack or a plurality of battery packs connected in parallel which is/are controlled by a Battery Management System (BMS) to connected to and disconnect from a high-voltage DC bus of the electric vehicle, wherein the battery system powers the electric vehicle; a range extender (3) to generate a DC current so as to charge the battery system and/or power the electric vehicle; a controller (4) to control a power generating mode of the range extender (3), to control a connection status of each battery pack with the high-voltage DC bus of the electric vehicle, and/or to control a connection status of the range extender (3) with the high-voltage DC bus of the electric vehicle; and a plurality of switches arranged between each battery pack and the high-voltage DC bus of the electric vehicle, and/or between the range extender (3) and the high-voltage DC bus of the electric vehicle.

Abstract: A JYB-based barter transaction platform where trades between sellers and buyers are denominated in JYB is used to settle all objects and services purchased or sold on the platform. The JYB is a trade measuring currency instead of a circulation currency, and cannot be directly exchanged with a circulation currency. Only when the amount of JYB is insufficient during a trade, can the JYB difference be supplemented by a circulation currency at the conversion rate; in the case of regular settlement of circulation currency, the barter transaction platform collects the amount of circulation currency that has been received and refunded to users by the conversion rate. JYB can replace any circulation currency to achieve real-time barter trade.

Abstract: The invention relates to the application of peptides that can self-assemble to form supramolecular nanofibrils and hydrogels, hydrogel compositions containing the self-assembled supramolecular nanofibrils, and methods of uses and making the hydrogel compositions.

Abstract: The invention relates to the application of peptides that can self-assemble to form supramolecular nanofibrils and hydrogels, hydrogel compositions containing the self-assembled supramolecular nanofibrils, and methods of uses and making the hydrogel compositions.

Abstract: A method and an apparatus for implementing multi-processor memory coherency are disclosed. The method includes: a Level-2 (L2) cache of a first cluster receives a control signal of the first cluster for reading first data; the L2 cache of the first cluster reads the first data in a Level-1 (L1) cache of a second cluster through an Accelerator Coherency Port (ACP) of the L1 cache of the second cluster if the first data is currently maintained by the second cluster, where the L2 cache of the first cluster is connected to the ACP of the L1 cache of the second cluster; and the L2 cache of the first cluster provides the first data read to the first cluster for processing. The technical solution under the present invention implements memory coherency between clusters in the ARM Cortex-A9 architecture.

Abstract: A method and an apparatus for implementing multi-processor memory coherency are disclosed. The method includes: a Level-2 (L2) cache of a first cluster receives a control signal of the first cluster for reading first data; the L2 cache of the first cluster reads the first data in a Level-1 (L1) cache of a second cluster through an Accelerator Coherency Port (ACP) of the L1 cache of the second cluster if the first data is currently maintained by the second cluster, where the L2 cache of the first cluster is connected to the ACP of the L1 cache of the second cluster; and the L2 cache of the first cluster provides the first data read to the first cluster for processing. The technical solution under the present invention implements memory coherency between clusters in the ARM Cortex-A9 architecture.