Abstract: A method and an apparatus for optimizing an mRNA sequence, an mRNA molecule, a pharmaceutical composition, and a use thereof are provided. The disclosure relates to the technical field of artificial intelligence, specifically to technical fields such as biological computing. The method for optimizing the mRNA sequence include: obtaining a first mRNA sequence for synthesizing a protein of interest, where the first mRNA sequence includes a 5? untranslated region sequence and a coding region sequence; and adjusting the 5? untranslated region sequence and the coding region sequence with the goal of maximizing a first score of the first mRNA sequence, so as to obtain an optimized second mRNA sequence for synthesizing the protein of interest, where the first score reflects at least one of the following indicators of the first mRNA sequence: translation initiation efficiency, codon adaptation index, and minimum free energy.

Abstract: In various examples, systems and methods are disclosed relating to geometric fabrics for accelerated policy learning and sim-to-real transfer in robotics systems, platforms, and/or applications. For example, a system can provide an input indicative of a goal pose for a robot to a model to cause the model to generate an output, the output representing a plurality of points along a path for movement of the robot to the goal pose; and generate one or more control signals for operation of the robot based at least on the plurality of points along the path and a policy corresponding to one or more criteria for the operation of the robot. In examples, the system can provide the one or more control signals to the robot to cause the robot to move toward the goal pose.

Abstract: Systems and techniques are described related to training one or more machine learning models for use in control of a robot. In at least one embodiment, one or more machine learning models are trained based at least on simulations of the robot and renderings of such simulations—which may be performed using one or more ray tracing algorithms, operations, or techniques.

Abstract: The present disclosure discloses a high-entropy alloy powder for laser cladding and a use method thereof. The alloy powder is CoCrFeMnNiCx, and x has a value of 0.1-0.15. The specific method includes: subjecting a 45 steel substrate to surface pretreatment, mixing the weighed CoCrFeMnNi high-entropy alloy powder with different content of a nano-C powder uniformly and pre-placed on the pre-treated substrate surface to form a prefabricated layer, then placing the prefabricated layer at 80-90° C. for constant temperature treatment for 8-12 h, and under a protective atmosphere, subjecting the cladding powder to laser cladding on the surface of the 45 steel. The method of the present disclosure prepares a CoCrFeMnNiCx high-entropy alloy coating with performance superior to the CoCrFeMnNi high-entropy alloy coating.

Abstract: Operation requests received from a tenant are added to a tenant-specific queue. A tenant scheduling work item is added to an execution queue that is shared with oilier tenants. When the tenant scheduling work item is executed, it copies up to a defined number of scheduled operations from the tenant-specific queue to the execution queue. The tenant-scheduling work item then re-adds itself to the execution queue. While the operations are executed and before the tenant scheduling work item is executed again, other tenants have an opportunity to queue their own operations. The tenant scheduling work item selects scheduled operations from the tenant-specific queue in the order they were originally requested until one of several conditions is met. Conditions may be based on how many operations are in progress, what kind of operations are in progress, and/or dependencies between operations of different types.

Abstract: The present disclosure discloses a high-entropy alloy powder for laser cladding and a use method thereof. The alloy powder is CoCrFeMnNiCx, and x has a value of 0.1-0.15. The specific method includes: subjecting a 45 steel substrate to surface pretreatment, mixing the weighed CoCrFeMnNi high-entropy alloy powder with different content of a nano-C powder uniformly and pre-placed on the pre-treated substrate surface to form a prefabricated layer, then placing the prefabricated layer at 80-90° C. for constant temperature treatment for 8-12 h, and under a protective atmosphere, subjecting the cladding powder to laser cladding on the surface of the 45 steel. The method of the present disclosure prepares a CoCrFeMnNiCx high-entropy alloy coating with performance superior to the CoCrFeMnNi high-entropy alloy coating.