Patents by Inventor Jinhe Li

Jinhe Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cholinergic/serotoninergic receptor and uses thereof
    Patent number: 8759504
    Abstract: The present invention describes new cholinergic/serotoninergic chimeric receptors and provides methods and compositions suitable for screening for ligands such as agonists, antagonists and allosteric modulators of ?7 nicotinic acetylcholine receptors.
    Type: Grant
    Filed: February 6, 2012
    Date of Patent: June 24, 2014
    Assignee: AbbVie Inc.
    Inventors: Murali Gopalakrishnan, Jinhe Li, Steven C. Cassar, John Malysz, David J. Anderson, Earl J. Gubbins, Daniel C. Bertrand
  • Pyrrole derivatives and their methods of use
    Patent number: 8609713
    Abstract: The invention relates to a series of substituted pyrrole derivatives, compositions comprising the same, and methods of treating conditions and disorders using such compounds and compositions.
    Type: Grant
    Filed: May 7, 2010
    Date of Patent: December 17, 2013
    Assignee: AbbVie Inc.
    Inventors: Ramin Faghih, Gregory A. Gfesser, Christopher L. Lynch, Murali Gopalakrishnan, Sujatha Gopalakrishnan, John Malysz, Earl J. Gubbins, Rachid El Kouhen, Jinhe Li
  • Thiazoline and oxazoline derivatives and their methods of use
    Patent number: 8470813
    Abstract: The invention relates to a series of thiazoline and oxazoline derivatives, compositions thereof, and methods of treating conditions and disorders using such compounds.
    Type: Grant
    Filed: January 28, 2010
    Date of Patent: June 25, 2013
    Assignee: AbbVie Inc.
    Inventors: Ramin Faghih, Gregory A. Gfesser, Christopher L. Lynch, Murali Gopalakrishnan, Sujatha Gopalakrishnan, John Malysz, Earl J. Gubbins, Rachid El Kouhen, Jinhe Li, Kathy A. Sarris, Melissa J. Michmerhuizen, Ying Wang
  • CHOLINERGIC/SEROTONINERGIC RECEPTOR AND USES THEREOF
    Publication number: 20120219967
    Abstract: The present invention describes new cholinergic/serotoninergic chimeric receptors and provides methods and compositions suitable for screening for ligands such as agonists, antagonists and allosteric modulators of ?7 nicotinic acetylcholine receptors.
    Type: Application
    Filed: February 6, 2012
    Publication date: August 30, 2012
    Inventors: Murali Gopalakrishnan, Jinhe Li, Steven C. Cassar, John Malysz, David J. Anderson, Earl J. Gubbins, Daniel C. Bertrand
  • Pyrrole Derivatives and Their Methods of Use
    Publication number: 20100216748
    Abstract: The invention relates to a series of substituted pyrrole derivatives, compositions comprising the same, and methods of treating conditions and disorders using such compounds and compositions.
    Type: Application
    Filed: May 7, 2010
    Publication date: August 26, 2010
    Applicant: ABBOTT LABORATORIES
    Inventors: Ramin Faghih, Gregory A. Gfesser, Christopher L. Lynch, Murali Gopalakrishnan, Sujatha Gopalakrishnan, John Malysz, Earl J. Gubbins, Rachid El Kouhen, Jinhe Li
  • Thiazoline and Oxazoline Derivatives and Their Methods of Use
    Publication number: 20100190776
    Abstract: The invention relates to a series of thiazoline and oxazoline derivatives, compositions thereof, and methods of treating conditions and disorders using such compounds.
    Type: Application
    Filed: January 28, 2010
    Publication date: July 29, 2010
    Applicant: ABBOTT LABORATORIES
    Inventors: Ramin Faghih, Gregory A. Gfesser, Christopher L. Lynch, Murali Gopalakrishnan, Sujatha Gopalakrishnan, John Malysz, Earl J. Gubbins, Rachid El Kouhen, Jinhe Li, Kathy A. Sarris, Melissa J. Michmerhuizen, Ying Wang
  • Pyrrole derivatives and their methods of use
    Patent number: 7741364
    Abstract: The invention relates to a series of substituted pyrrole derivatives, compositions comprising the same, and methods of treating conditions and disorders using such compounds and compositions.
    Type: Grant
    Filed: June 27, 2007
    Date of Patent: June 22, 2010
    Assignee: Abbott Laboratories
    Inventors: Ramin Faghih, Gregory A. Gfesser, Christopher L. Lynch, Murali Gopalakrishnan, Sujatha Gopalakrishnan, John Malysz, Earl J. Gubbins, Rachid El Kouhen, Jinhe Li
  • Thiazoline and oxazoline derivatives and their methods of use
    Patent number: 7683084
    Abstract: The invention relates to a series of thiazoline and oxazoline derivatives, compositions thereof, and methods of treating conditions and disorders using such compounds.
    Type: Grant
    Filed: June 27, 2007
    Date of Patent: March 23, 2010
    Assignee: Abbott Laboratories
    Inventors: Ramin Faghih, Gregory A. Gfesser, Christopher L. Lynch, Murali Gopalakrishnan, Sujatha Gopalakrishnan, John Malysz, Earl J. Gubbins, Rachid El Kouhen, Jinhe Li, Kathy A. Sarris, Melissa J. Michmerhuizen, Ying Wang
  • CHOLINERGIC/SEROTONINERGIC RECEPTOR AND USES THEREOF
    Publication number: 20090123945
    Abstract: The present invention describes new cholinergic/serotoninergic chimeric receptors and provides methods and compositions suitable for screening for ligands such as agonists, antagonists and allosteric modulators of ?7 nicotinic acetylcholine receptors.
    Type: Application
    Filed: June 25, 2008
    Publication date: May 14, 2009
    Applicant: ABBOTT LABORATORIES
    Inventors: Murali Gopalakrishnan, Jinhe Li, Steven C. Cassar, John Malysz, David J. Anderson, Earl J. Gubbins, Daniel C. Bertrand
  • IMMUNOASSAY FOR DETECTION AND QUANTIFICATION OF AMYLOID-beta PEPTIDES
    Publication number: 20080234311
    Abstract: The present invention provides a method for the detection and quantification of A?1-40 produced in native cell types and tissues. Also provided are assays and kits to determine the effect of compounds on the production of amyloid ? peptides.
    Type: Application
    Filed: November 19, 2007
    Publication date: September 25, 2008
    Inventors: Jinhe Li, Murali Gopalakrishnan
  • THIAZOLINE AND OXAZOLINE DERIVATIVES AND THEIR METHODS OF USE
    Publication number: 20080070929
    Abstract: The invention relates to a series of thiazoline and oxazoline derivatives, compositions thereof, and methods of treating conditions and disorders using such compounds.
    Type: Application
    Filed: June 27, 2007
    Publication date: March 20, 2008
    Inventors: Ramin Faghih, Gregory Gfesser, Christopher Lynch, Murali Gopalakrishnan, Sujatha Gopalakrishnan, John Malysz, Earl Gubbins, Rachid Kouhen, Jinhe Li, Kathy Sarris, Melissa Michmerhuizen, Ying Wang
  • PYRROLE DERIVATIVES AND THEIR METHODS OF USE
    Publication number: 20080064695
    Abstract: The invention relates to a series of substituted pyrrole derivatives, compositions comprising the same, and methods of treating conditions and disorders using such compounds and compositions.
    Type: Application
    Filed: June 27, 2007
    Publication date: March 13, 2008
    Inventors: Ramin Faghih, Gregory Gfesser, Christopher Lynch, Murali Gopalakrishnan, Sujatha Gopalakrishnan, John Malysz, Earl Gubbins, Rachid El Kouhen, Jinhe Li
  • Human sel-10 polypeptides and polynucleotides that encode them
    Publication number: 20050095671
    Abstract: The present invention provides isolated nucleic acid molecules comprising a polynucleotide encoding either of two alternative splice variants of human sel-10, one of which is expressed in hippocampal cells, and one of which is expressed in mammary cells. The invention also provides isolated sel-10 polypeptides and cell lines which express them in which A? processing is altered.
    Type: Application
    Filed: September 2, 2003
    Publication date: May 5, 2005
    Inventors: Mark Gurney, Adele Pauley, Jinhe Li
  • Human sel-10 polypeptides and polynucleotides that encode them
    Publication number: 20040115700
    Abstract: The present invention provides isolated nucleic acid molecules comprising a polynucleotide encoding either of two alternative splice variants of human sel-10, one of which is expressed in hippocampal cells, and one of which is expressed in mammary cells. The invention also provides isolated sel-10 polypeptides and cell lines which express them in which A&bgr; processing is altered.
    Type: Application
    Filed: September 2, 2003
    Publication date: June 17, 2004
    Inventors: Mark E. Gurney, Adele M. Pauley, Jinhe Li
  • Human sel-10 polypeptides and polynucleotides that encode them
    Publication number: 20040116672
    Abstract: The present invention provides isolated nucleic acid molecules comprising a polynucleotide encoding either of two alternative splice variants of human sel-10, one of which is expressed in hippocarnpal cells, and one of which is expressed in mammary cells. The invention also provides isolated sel-10 polypeptides and cell lines which express them in which A&bgr; processing is altered.
    Type: Application
    Filed: September 2, 2003
    Publication date: June 17, 2004
    Inventors: Mark E. Gurney, Adele M. Pauley, Jinhe Li
  • Human sel-10 polypeptides and polynucleotides that encode them
    Publication number: 20040110202
    Abstract: The present invention provides isolated nucleic acid molecules comprising a polynucleotide encoding either of two alternative splice variants of human sel-10, one of which is expressed in hippocampal cells, and one of which is expressed in mammary cells. The invention also provides isolated sel-10 polypeptides and cell lines which express them in which A&bgr; processing is altered.
    Type: Application
    Filed: September 2, 2003
    Publication date: June 10, 2004
    Inventors: Mark E. Gurney, Adele M. Pauley, Jinhe Li
  • Human sel-10 polypeptides and polynucleotides that encode them
    Patent number: 6730778
    Abstract: The present invention provides isolated nucleic acid molecules comprising a polynucleotide encoding either of two alternative splice variants of human sel-10, one of which is expressed in hippocampal cells, and one of which is expressed in mammary cells. The invention also provides isolated sel-10 polypeptides and cell lines which express them in which A&bgr; processing is altered.
    Type: Grant
    Filed: June 9, 1999
    Date of Patent: May 4, 2004
    Assignee: Pharmacia and Upjohn Company
    Inventors: Mark E. Gurney, Adele M. Pauley, Jinhe Li
  • Human sel-10 polypeptides and polynucleotides that encode them
    Patent number: 6638731
    Abstract: The present invention provides isolated nucleic acid molecules comprising a polynucleotide encoding either of two alternative splice variants of human sel-10, one of which is expressed in hippocampal cells, and one of which is expressed in mammary cells. The invention also provides isolated sel-10 polypeptides and cell lines which express them in which A&bgr; processing is altered.
    Type: Grant
    Filed: December 17, 1998
    Date of Patent: October 28, 2003
    Assignee: Pharmacia and Upjohn Company
    Inventors: Mark E. Gurney, Adele M. Pauley, Jinhe Li
  • HUMAN SEL-10 POLYPEPTIDES AND POLYNUCLEOTIDES THAT ENCODE THEM
    Publication number: 20020177187
    Abstract: The present invention provides isolated nucleic acid molecules comprising a polynucleotide encoding either of two alternative splice variants of human sel-10, one of which is expressed in hippocampal cells, and one of which is expressed in mammary cells. The invention also provides isolated sel-10 polypeptides and cell lines which express them in which A&bgr; processing is altered.
    Type: Application
    Filed: June 9, 1999
    Publication date: November 28, 2002
    Inventors: MARK E. GURNEY, ADELE M. PAULEY, JINHE LI
  • HUMAN SEL-10 POLYPEPTIDES AND POLYNUCLEOTIDES THAT ENCODE THEM
    Publication number: 20020164683
    Abstract: The present invention provides isolated nucleic acid molecules comprising a polynucleotide encoding either of two alternative splice variants of human sel-10, one of which is expressed in hippocampal cells, and one of which is expressed in mammary cells. The invention also provides isolated sel-10 polypeptides and cell lines which express them in which A&bgr; processing is altered.
    Type: Application
    Filed: December 17, 1998
    Publication date: November 7, 2002
    Inventors: MARK E. GURNEY, ADELE M. PAULEY, JINHE LI