Abstract: The present invention relates to anti-DDR2 antibodies. More specifically, the present invention relates to nano-antibodies binding to DDR2 and various derivatives of the nano-antibodies. The present invention also relates to pharmaceutical compositions comprising these antibodies and derivatives and pharmaceutical uses thereof. The anti-DDR2 nano-antibodies of the present invention have strong binding activity and can be used for diagnosis, prevention and/or treatment of diseases mediated by abnormal DDR2 expression (such as cancer and inflammatory diseases), as well as imaging of cells expressing DDR2, such as biopsy navigation and intraoperative navigation.

Abstract: A combined system of a concealed closed tracheoscope and an artificial airway breathing circuit includes an artificial airway breathing tubing and a tracheoscope. The artificial airway breathing tubing includes an inhalation circuit and an exhalation circuit that are connected through a connecting tube. The tracheoscope includes a handle portion and an insertion portion connected to the handle portion. The tracheoscope handle portion wraps around a section of the exhalation circuit. The tracheoscope insertion portion is hidden in the extendable breathing circuit, which extends and retracts to make the tracheoscope insertion portion advance or retreat in a closed condition. The tracheoscope handle function assembly cleverly wraps around the surface of the breathing circuit tubing, organically combining the functions of the tracheoscope handle and the breathing circuit.

Abstract: A combined system of a concealed closed tracheoscope and an artificial airway breathing circuit includes an artificial airway breathing tubing and a tracheoscope. The artificial airway breathing tubing includes an inhalation circuit and an exhalation circuit that are connected through a connecting tube. The tracheoscope includes a handle portion and an insertion portion connected to the handle portion. The tracheoscope handle portion wraps around a section of the exhalation circuit. The tracheoscope insertion portion is hidden in the extendable breathing circuit, which extends and retracts to make the tracheoscope insertion portion advance or retreat in a closed condition. The tracheoscope handle function assembly cleverly wraps around the surface of the breathing circuit tubing, organically combining the functions of the tracheoscope handle and the breathing circuit.