Abstract: A toll-like receptor agonist, and preparation therefor and an application thereof are provided. Specifically, a compound as shown in formula I, a preparation method therefor, and a use thereof as a TLR7 and/or TLR8 agonist are provided. The compound can be used for preparing a pharmaceutical composition for treating or preventing tumors or infection caused by virus.

Abstract: This application discloses an audio signal processing method, a model training method, and related apparatus. The audio signal processing method includes inputting a first audio input signal into a machine learning model to obtain a first howling point, and obtaining a first gain value according to the first howling point, the first howling point corresponding to an effective audio signal in the first audio input signal, and the first gain value indicating a suppression parameter of the first howling point; processing the first audio input signal according to the first gain value to obtain a second audio input signal; detecting a second howling point, and obtaining a second gain value according to the second howling point, the second howling point corresponding to a frequency band of an ineffective audio signal in the second audio input signal; and processing the second audio input signal to obtain an audio output signal.

Abstract: Disclosed are a dihydropyrimidine compound, a preparation method therefor and an application thereof. Specifically, disclosed are a dihydropyrimidine compound represented by formula 1? or a pharmaceutically acceptable salt thereof, a composition comprising the compound, and an application of the compound in preparing a drug for treating and preventing hepatitis B virus (HBV) infection related diseases. The disclosed dihydropyrimidine compound can effectively suppress the activity of HBV in HepG2.2.15 cells, and is less toxic to liver cancer cells.

Abstract: This application discloses an audio signal processing method, a model training method, and related apparatus. The audio signal processing method includes inputting a first audio input signal into a machine learning model to obtain a first howling point, and obtaining a first gain value according to the first howling point, the first howling point corresponding to an effective audio signal in the first audio input signal, and the first gain value indicating a suppression parameter of the first howling point; processing the first audio input signal according to the first gain value to obtain a second audio input signal; detecting a second howling point, and obtaining a second gain value according to the second howling point, the second howling point corresponding to a frequency band of an ineffective audio signal in the second audio input signal; and processing the second audio input signal to obtain an audio output signal.

Abstract: A composition of matter, including a phlogopite powder or muscovite powder, clinoptilolite or mordenite, and kaolinite. The composition of matter is prepared as follows: 1) mixing the phlogopite powder or muscovite powder, the clinoptilolite or mordenite, and the kaolinite in a weight ratio of 50-70:0-30:0-50; adding a solution including isopropanol and n-butanol to a mixture of the phlogopite powder or muscovite powder, the clinoptilolite or mordenite, and the kaolinite, thereby yielding a mixed solution; 2) adding a silane coupling agent to the mixed solution, and continuously magnetically stirring the mixed solution for 30 min; adding distilled water to the mixed solution, and continuously magnetically stirring for 30 min; and adding methyl silicone oil to the mixed solution, and magnetically stirring for an hour, thereby yielding a slurry; and 3) drying the slurry at a temperature of 150-200° C.

Abstract: In one aspect, a lighting fixture may include a light cover, a base and a power cord. In one embodiment, the light cover is hollow to receive a light bulb and made by crystal salt that can be used to emit negative ions to enhance the user's health. In another embodiment, a connecting plate is secured at a bottom portion of the light cover, and the connecting cover has a plurality of screw holes. The base has a circular operating plate that has a plurality of heat dissipating holes surrounding the operating plate to dissipate the heat generate from the light bulb. The operating plate also has a plurality of screw holes corresponding to the screw holes of the connecting plate, so when the screw holes on the operating plate are aligned with the screw holes on the connecting plate, the screws can be inserted into these screw holes to secure the light cover on the base.

Abstract: A device for medical and healthcare management includes a main frame and a base extended from a bottom end of the main frame; a user identification arrangement arranged on the main frame to one-by-one identify user's information; a multimedia output arrangement arranged on the main frame to display and play texts, images, pictures, sound, animations, videos, and achieve other interactive functions; a health parameter detection arrangement arranged on the main frame and the base to detect various health parameters for the users; and a communication arrangement arranged on the main frame to communicate with external electronic devices.

Abstract: Embodiments of the present invention disclose an audio encoding method. The method includes: obtaining audio data of N channels; and performing channel interleaving and packetization on the obtained audio data of the N channels to obtain data packets, where each data packet includes X*N segments of audio data, where X is a ratio of an amount of audio data included in one data packet to an amount of audio data included in one audio frame, X is an integer greater than or equal to 1, and in the X*N segments of audio data, at least X+1 segments of audio data belong to different audio frames.