Abstract: This application provides a HARQ codebook generation method and a related device. The method includes: receiving, by a terminal, first information, where the first information is used to indicate carriers configured by the access network device for the terminal, the configured carriers include a first carrier and a second carrier, HARQ feedback information of the first carrier and HARQ feedback information of the second carrier are transmitted on an uplink control channel of the first carrier, and a transmission time unit length of the first carrier is not equal to a transmission time unit length of the second carrier; and generating, by the terminal based on HARQ timing of the configured carriers and a relationship between the transmission time unit length of the first carrier and the transmission time unit length of the second carrier, a HARQ codebook transmitted on the uplink control channel of the first carrier.

Abstract: Embodiments of the present invention disclose a reference signal transmission method. A transmitting apparatus multiplies M first symbol sequences by M coefficients respectively to obtain M second symbol sequences, where M is a positive integer greater than 1, the symbol sequence includes L symbols, L is a positive integer greater than 1, and the M coefficients each have a magnitude of 1. The transmitting apparatus maps the M second symbol sequences onto a first time-frequency resource to obtain a frequency domain signal. The transmitting apparatus performs an IFFT operation on the frequency domain signal to obtain a time domain signal. And the transmitting apparatus sends the time domain signal.

Abstract: Embodiments of the present disclosure provide a data processing method and apparatus. The method includes: preprocessing, by a transmit end, data transmitted on at least two first-type symbols in a radio frame that are parallel, and converting the data transmitted on the at least two parallel first-type symbols into data transmitted on a shared symbol; adding, by the transmit end, a first CP to the data transmitted on the shared symbol; and sending, to a receive end, the data that is transmitted on the shared symbol and to which the first CP is added.

Abstract: This application discloses a control information sending method, a data block transmission method, and a related apparatus. The control information sending method in this application is used to schedule multiple transmission time intervals TTIs for data transmission, and the multiple TTIs include at least a first TTI and a second TTI.

Abstract: A magnetizable glass ceramic composition including: a continuous first glass phase including SiO2, B2O3, P2O5, and R2O; a discontinuous second glass phase including at least one of SiO2, B2O3, P2O5, R2O, or mixtures thereof; and a discrete magnetizable crystalline phase dispersed in the discontinuous second glass phase, where R2O is selected from at least one of K2O, Li2O, Na2O, or mixtures thereof. Also disclosed are a method of making and a method of using the magnetizable glass ceramic composition.

Abstract: A magnetizable glass ceramic composition including: a continuous first glass phase including SiO2, B2O3, P2O5, and R2O; a discontinuous second glass phase including at least one of SiO2, B2O3, P2O5, R2O, or mixtures thereof; and a discrete magnetizable crystalline phase dispersed in the discontinuous second glass phase, where R2O is selected from at least one of K2O, Li2O, Na2O, or mixtures thereof. Also disclosed are a method of making and a method of using the magnetizable glass ceramic composition.

Abstract: The present disclosure relates to buffers containing polyols for use with affinity-binding and/or magnetically susceptible thermoplastic particles and methods of making and use thereof.

Abstract: The present disclosure relates to buffers containing polyols for use with affinity-binding and/or magnetically susceptible thermoplastic particles and methods of making and use thereof.

Abstract: A label-free cell assay method including: culturing rigid cells in a buffer, the rigid cells having a diameter of about 3 to about 7 micrometers; depositing the rigid cells on the surface of a sensor system; and detecting the rigid cells with the sensor when exposed to two or more wavelengths of light having two or more penetration depths, as defined herein. Also disclosed are assay methods for contacting the rigid cells with a substance and determining the response of the contacted rigid cells to the substance, such as a drug candidate or modulator compound, as defined herein.

Abstract: A surface plasmon resonance sensor system including a high refractive index prism, a sensor chip, a light source having multiple wavelengths over a broad range of wavelengths, optical lenses, a photodetector, a data acquisition unit, and as defined herein. The sensor chip can include, for example, a thin layer of silicon and gold on one face of a transparent substrate and the prism adjacent to the opposite face of the transparent substrate. Such an arrangement provides variable penetration depths up to about 1.5 micrometers with a dynamic range for sensing index of refraction changes in a sample that are several times greater than that of a conventional SPR sensor. The disclosure provides methods for using the surface plasmon resonance sensor system for cell assay or chemical assay related applications.

Abstract: Systems and methods for sensing a surface plasmon resonance (SPR) biosensor using two or more wavelengths and with reduced chromatic aberration are disclosed. The system includes a beam-forming optical system that has chromatic aberration at the two or more wavelengths. A light source system provides respectively light of the two or more wavelengths, with light of each wavelength provided from a different distance from the beam-forming optical system. The different distances are selected to reduce or eliminate adverse effects of chromatic aberration on the formation of a focus spot on the SPR biosensor chip. An illumination system for illuminating a SPR biosensor using different light having different wavelengths is also disclosed.

Abstract: A surface plasmon resonance sensor system including a high refractive index prism, a sensor chip, a light source having multiple wavelengths over a broad range of wavelengths, optical lenses, a photodetector, a data acquisition unit, and as defined herein. The sensor chip can include, for example, a thin layer of silicon and gold on one face of a transparent substrate and the prism adjacent to the opposite face of the transparent substrate. Such an arrangement provides variable penetration depths up to about 1.5 micrometers with a dynamic range for sensing index of refraction changes in a sample that are several times greater than that of a conventional SPR sensor. The disclosure provides methods for using the surface plasmon resonance sensor system for cell assay or chemical assay related applications.

Abstract: A surface plasmon resonance sensor system including a high refractive index prism, a sensor chip, a light source having multiple wavelengths over a broad range of wavelengths, optical lenses, a photodetector, a data acquisition unit, and as defined herein. The sensor chip can include, for example, a thin layer of silicon and gold on one face of a transparent substrate and the prism adjacent to the opposite face of the transparent substrate. Such an arrangement provides variable penetration depths up to about 1.5 micrometers with a dynamic range for sensing index of refraction changes in a sample that are several times greater than that of a conventional SPR sensor. The disclosure provides methods for using the surface plasmon resonance sensor system for cell assay or chemical assay related applications.

Abstract: A surface plasmon resonance sensor system including a high refractive index prism, a sensor chip, a light source having multiple wavelengths over a broad range of wavelengths, optical lenses, a photodetector, a data acquisition unit, and as defined herein. The sensor chip can include, for example, a thin layer of silicon and gold on one face of a transparent substrate and the prism adjacent to the opposite face of the transparent substrate. Such an arrangement provides variable penetration depths up to about 1.5 micrometers with a dynamic range for sensing index of refraction changes in a sample that are several times greater than that of a conventional SPR sensor. The disclosure provides methods for using the surface plasmon resonance sensor system for cell assay or chemical assay related applications.

Abstract: An optical reader system and method are described herein that can detect a lateral and/or angular misalignment of one or more biosensors so that the biosensors can be properly re-located after being removed from and then reinserted into the optical reader system. In one embodiment, the biosensors are incorporated within the wells of a microplate.

Abstract: Described herein are polymer-coated substrates for binding biomolecules and methods of making and using thereof.

Abstract: Buffered assay solutions for performing 1) binding or 2) functional assays on GPCR arrays, along with methods for their use are described. The buffered assay solution has an underlying composition having: a buffer reagent with a pH in the range of about 6.5 to about 7.9; an inorganic salt of either a monovalent or divalent species, at a concentration from about 1 mM to about 500 mM; and optionally a combination of: c) a blocker reagent at a concentration of about 0.01 wt. % to about 2 wt. % of the composition, or d) protease-inhibitor at a concentration of about 0.001 mM to about 100 mM. In an embodiment for functional assay uses, the composition is modified to also include a GTP-analogue, a guanosine 5?-diphosphate (GDP) salt, and/or an anti-oxidant reagent.

Abstract: Buffered assay solutions for performing 1) binding or 2) functional assays on GPCR arrays, along with methods for their use are described. The buffered assay solution has an underlying composition having: a buffer reagent with a pH in the range of about 6.5 to about 7.9; an inorganic salt of either a monovalent or divalent species, at a concentration from about 1 mM to about 500 mM; and optionally a combination of: c) a blocker reagent at a concentration of about 0.01 wt. % to about 2 wt. % of the composition, or d) protease-inhibitor at a concentration of about 0.001 mM to about 100 mM. In an embodiment for functional assay uses, the composition is modified to also include a GTP-analogue, a guanosine 5?-diphosphate (GDP) salt, and/or an anti-oxidant reagent.

Abstract: Buffered assay solutions for performing 1) binding or 2) functional assays on GPCR arrays, along with methods for their use are described. The buffered assay solution has an underlying composition having: a buffer reagent with a pH in the range of about 6.5 to about 7.9; an inorganic salt of either a monovalent or divalent species, at a concentration from about 1 mM to about 500 mM; and optionally a combination of: c) a blocker reagent at a concentration of about 0.01 wt. % to about 2 wt. % of the composition, or d) protease-inhibitor at a concentration of about 0.001 mM to about 100 mM. In an embodiment for functional assay uses, the composition is modified to also include a GTP-analogue, a guanosine 5?-diphosphate (GDP) salt, and/or an anti-oxidant reagent.

Abstract: An optical reader system is described herein that uses a scanned optical beam to interrogate a biosensor to determine if a biomolecular binding event occurred on a surface of the biosensor. In one embodiment, the optical reader system includes a light source, a detector and a processor (e.g., computer, DSP). The light source outputs an optical beam which is scanned across a moving biosensor and while this is happening the detector collects the optical beam which is reflected from the biosensor. The computer processes the collected optical beam and records the resulting raw spectral or angle data which is a function of a position (and possibly time) on the biosensor. The processor can then analyze the raw data to create a spatial map of resonant wavelength (peak position) or resonant angle which indicates whether or not a biomolecular binding event occurred on the biosensor. Several other uses of the raw data are also described herein.