Abstract: A heat management safety enhanced vehicle battery pack based on nested lithium ion batteries includes an insulating housing. K insulating positioning and connecting plates are arranged in the insulating housing along a vertical direction. The positioning and connecting plate on each layer includes the batteries in M rows and N columns to form battery pack units. All the battery pack units perform output alone or perform output after being connected in series or in parallel to form a battery pack. Each battery includes a metal shell and a cell filled in the shell. The shell includes an inner cylinder and an outer cylinder. The inner cylinder is located in a through hole in the center of the outer cylinder. A gap is formed between a side wall of the inner cylinder and a secondary outer wall of the outer cylinder. The cell includes an outer cell and an inner cell.

Abstract: A nested structure lithium ion battery capable of reducing a risk of thermal runaway includes a metal housing and a battery cell filled in the housing. The housing includes an inner cylinder and an outer cylinder. The inner cylinder is located in a through hole in the center of the outer cylinder, and there is a gap between a side wall of the inner cylinder and a secondary outer wall of the outer cylinder. The battery cell includes an outer battery cell and an inner battery cell. The outer battery cell is filled in a cavity of the outer cylinder, and the inner battery cell is filled in a cavity of the inner cylinder. This nested structure lithium ion battery divides the battery cell into two parts. The gap is used as a heat dissipation channel in a high temperature environment.

Abstract: The present invention discloses a testing method and a testing system for a safe operating window of a lithium-ion battery in a squeezed state. The testing system includes a mechanical loading device, a heating device, a lithium-ion battery tester and a measuring device. By comparing the influence of a combined use of two or more of mechanical abuse with two different fixed variables, thermal abuse, and electrical abuse on critical conditions of thermal runaway of the lithium-ion battery, the influence of the different forms of abuse on the critical conditions of thermal runaway of the lithium-ion battery can be compared qualitatively and quantitatively, and these data can also be used to determine the safe operating windows of the lithium-ion battery under different abuse conditions.

Abstract: The present invention discloses a testing method and a testing system for a safe operating window of a lithium-ion battery in a squeezed state. The testing system includes a mechanical loading device, a heating device, a lithium-ion battery tester and a measuring device. By comparing the influence of a combined use of two or more of mechanical abuse with two different fixed variables, thermal abuse, and electrical abuse on critical conditions of thermal runaway of the lithium-ion battery, the influence of the different forms of abuse on the critical conditions of thermal runaway of the lithium-ion battery can be compared qualitatively and quantitatively, and these data can also be used to determine the safe operating windows of the lithium-ion battery under different abuse conditions.

Abstract: A system and method for early-warning and positioning of overheating in a lithium ion battery pack is disclosed, especially for a single battery in the lithium ion battery pack during use. The system Includes a sensor unit, a controller unit, an alarm unit and an auxiliary unit; the sensor unit includes a special flexible thin film sensor; the controller unit includes a single chip microprocessor, an alarm controller, a computer and a display, the single chip microprocessor and the alarm controller being connected to the computer, the computer being connected to the display; the alarm unit includes a LED alarm light and a buzzer; the single chip microprocessor of the controller unit is connected to the flexible film sensor; the auxiliary unit includes a power supply and a constant value resistor; the power supply provides power separately to the controller unit and the alarm unit, and the constant value resistor is directly connected to the power supply.

Abstract: Provided are certain novel pyrazine derivatives (I) as SHP2 inhibitors which is shown as formula (I), their synthesis and their use for treating a SHP2 mediated disorder. More particularly, provided are fused heterocyclic derivatives useful as inhibitors of SHP2, methods for producing such compounds and methods for treating a SHP2-mediated disorder.

Abstract: Provided are certain novel pyrazine derivatives (I) as SHP2 inhibitors which is shown as formula (I), their synthesis and their use for treating a SHP2 mediated disorder. More particularly, provided are fused heterocyclic derivatives useful as inhibitors of SHP2, methods for producing such compounds and methods for treating a SHP2-mediated disorder.

Abstract: Heterocyclic pyrimidine compounds that modulate mutant-selective epidermal growth factor receptor (EGFR) and ALK kinase activity are disclosed. More specifically, the invention provides pyrimidines which inhibit, regulate and/or modulate kinase receptor, particularly in selectively modulation of various EGFR mutant activity and ALK kinase activity have been disclosed. Pharmaceutical compositions comprising the pyrimidine derivative, and methods of treatment for diseases associated with protein kinase enzymatic activity, particularly EGFR or ALK kinase activity including non-small cell lung cancer comprising administration of the pyrimidine derivative are disclosed.

Abstract: Heterocyclic pyrimidine compounds that modulate mutant-selective epidermal growth factor receptor (EGFR) and ALK kinase activity are disclosed. More specifically, the invention provides pyrimidines which inhibit, regulate and/or modulate kinase receptor, particularly in selectively modulation of various EGFR mutant activity and ALK kinase activity have been disclosed. Pharmaceutical compositions comprising the pyrimidine derivative, and methods of treatment for diseases associated with protein kinase enzymatic activity, particularly EGFR or ALK kinase activity including non-small cell lung cancer comprising administration of the pyrimidine derivative are disclosed.

Abstract: Heterocyclic pyrimidine compounds that modulate mutant-selective epidermal growth factor receptor (EGFR) and ALK kinase activity are disclosed. More specifically, the invention provides pyrimidines which inhibit, regulate and/or modulate kinase receptor, particularly in selectively modulation of various EGFR mutant activity and ALK kinase activity have been disclosed. Pharmaceutical compositions comprising the pyrimidine derivative, and methods of treatment for diseases associated with protein kinase enzymatic activity, particularly EGFR or ALK kinase activity including non-small cell lung cancer comprising administration of the pyrimidine derivative are disclosed.

Abstract: Heterocyclic pyrimidine compounds that modulate mutant-selective epidermal growth factor receptor (EGFR) and ALK kinase activity are disclosed. More specifically, the invention provides pyrimidines which inhibit, regulate and/or modulate kinase receptor, particularly in selectively modulation of various EGFR mutant activity and ALK kinase activity have been disclosed. Pharmaceutical compositions comprising the pyrimidine derivative, and methods of treatment for diseases associated with protein kinase enzymatic activity, particularly EGFR or ALK kinase activity including non-small cell lung cancer comprising administration of the pyrimidine derivative are disclosed.