Abstract: The present disclosure provides a testis-targeted lycopene (LYC)/ZIF-90 nanocomposite and a preparation method and use thereof, belonging to the technical field of targeted drugs. In the present disclosure, a ZIF-90 metal-organic framework (MOF) material is combined with LYC through aldol condensation; when entering areas of inflammatory response and oxidative stress response, ZIF-90 may disintegrate and collapse in a slightly-acidic environment, releasing the LYC, thereby avoiding easy oxidation of the LYC and improving a bioavailability of the LYC; in addition, the disintegrated and collapsed ZIF-90 may also be utilized by organisms, thus greatly reducing a damage to the organisms. Moreover, the LYC/ZIF-90 nanocomposite is further loaded with follicle-stimulating hormone (FSH).

Abstract: Disclosed are compounds inhibiting the conversion of ?-KG to D-2-HG, pharmaceutically acceptable salts, hydrates, solvates or stereoisomers thereof and pharmaceutical compositions comprising the compounds. The compound and the pharmaceutical composition can effectively treat IDH associated diseases, including cancer.

Abstract: A method for preparing a press-hardened steel component is provided. The method includes forming a heated blank by heating a steel alloy blank to a first temperature in a first zone of a furnace having two or more zones, and after the heating of the steel alloy blank to the first temperature, heating the steel alloy blank to a second temperature in a second zone of the furnace. The second temperature is greater than the first temperature. The first zone has a first flow rate for a protective gas, and the second zone has a second flow rate for the protective gas that is greater than the first flow rate. The method further includes stamping and quenching the heated blank at a constant rate to a temperature between a martensite finish temperature of the steel alloy defining the steel alloy blank and room temperature to form the press-hardened steel component.

Abstract: A method for preparing a press-hardened steel component is provided. The method includes forming a heated blank by heating a steel alloy blank to a first temperature in a first zone of a furnace having two or more zones, and after the heating of the steel alloy blank to the first temperature, heating the steel alloy blank to a second temperature in a second zone of the furnace. The second temperature is greater than the first temperature. The first zone has a first flow rate for a protective gas, and the second zone has a second flow rate for the protective gas that is greater than the first flow rate. The method further includes stamping and quenching the heated blank at a constant rate to a temperature between a martensite finish temperature of the steel alloy defining the steel alloy blank and room temperature to form the press-hardened steel component.

Abstract: A device includes an optic in an at least partially rigid scaffold. The scaffold is permeated, at least temporarily during a writing process, by writable media. The optic may be written into a writable volume in the scaffold defined by the writable media. The optic may be written by exposing the writable media to incident light to cause a material property change in the writable media within the writable volume.

Abstract: Objects and/or grouped emitters are anti-symmetrically excited. The anti-symmetric radiation emitted by the objects generate an interference pattern with a node in the spacing between the objects. The spacing may be sub-wavelength and/or below a resolution limit for the emitted radiation. Samples within the spacing may be detected via distortion to the inference pattern and visualized (including sub-resolution limit features) either directly or through reconstruction analysis from the interference pattern.

Abstract: A device includes an optic in an at least partially rigid scaffold. The scaffold is permeated, at least temporarily during a writing process, by writable media. The optic may be written into a writable volume in the scaffold defined by the writable media. The optic may be written by exposing the writable media to incident light to cause a material property change in the writable media within the writable volume.

Abstract: An isolator for a wheel hub between a brake rotor and a wheel is described, and includes a disk-shaped annular device including an inner ring, an outer ring, a first face portion, a second face portion, a plurality of apertures, a plurality of drain surface portions, and a plurality of radially-oriented drain channels disposed on the first face portion. Each drain channel is recessed in the first face portion. Each drain surface portion is recessed in the first face portion and is fluidly coupled to one of the drain channels. Each of the drain surface portions includes a continuous surface that is recessed from the first face portion between a drainage curve, a respective drain channel, and an arc that is defined on the inner ring between a first point and the respective drain channel.

Abstract: Methods and apparatus for concentrating light into a specified focal volume and for collecting light from a specified volume. Incident light is coupled through a plurality of successive transmissive asymmetric microstructure elements. The succession of transmissive asymmetric microstructure elements may be designed by representing an electromagnetic field as a linear combination of eigenmodes of one of the succession of transmissive asymmetric microstructure elements. The asymmetric microstructure elements are represented as a plurality of mesh lattice units and eigenmode solutions to Maxwell's equations are obtained for each mesh lattice unit subject to consistent boundary conditions. S-matrix formalism is employed to calculate a field output and weighting coefficients for the eigenmodes are selected to achieve a specified set of field output characteristics.

Abstract: An isolator for a wheel hub between a brake rotor and a wheel rim is described, and includes a disk-shaped annular device including an inner ring, an outer ring, a first face portion, a second face portion, a plurality of apertures, a plurality of drain surface portions, and a plurality of radially-oriented drain channels disposed on the first face portion. Each drain channel is recessed in the first face portion. Each drain surface portion is recessed in the first face portion and is fluidly coupled to one of the drain channels. Each of the drain surface portions includes a continuous surface that is recessed from the first face portion between a drainage curve, a respective drain channel, and an arc that is defined on the inner ring between a first point and the respective drain channel.

Abstract: Provided is a method of displaying and controlling a plurality of sub-screens on a display apparatus. A plurality of sub-screens of a preset number are displayed on a screen of the display apparatus, and the sub-screens are respectively bound to different input devices, and a control instruction sent from the input devices to the display apparatus independently controls only a sub-screen bound to a particular input device, and does not affect other sub-screens that are not bound to the particular input device. A user of a display may use various services at the same time via the plurality of independent sub-screens displayed on the screen of the display apparatus, and a plurality of users may share a large screen of the display apparatus and view respectively desired content at the same time.

Abstract: Provided is a method of displaying and controlling a plurality of sub-screens on a display apparatus. A plurality of sub-screens of a preset number are displayed on a screen of the display apparatus, and the sub-screens are respectively bound to different input devices, and a control instruction sent from the input devices to the display apparatus independently controls only a sub-screen bound to a particular input device, and does not affect other sub-screens that are not bound to the particular input device. A user of a display may use various services at the same time via the plurality of independent sub-screens displayed on the screen of the display apparatus, and a plurality of users may share a large screen of the display apparatus and view respectively desired content at the same time.

Abstract: Methods and apparatus for concentrating light into a specified focal volume and for collecting light from a specified volume. Incident light is coupled through a plurality of successive transmissive asymmetric microstructure elements. The succession of transmissive asymmetric microstructure elements may be designed by representing an electromagnetic field as a linear combination of eigenmodes of one of the succession of transmissive asymmetric microstructure elements. The asymmetric microstructure elements are represented as a plurality of mesh lattice units and eigenmode solutions to Maxwell's equations are obtained for each mesh lattice unit subject to consistent boundary conditions. S-matrix formalism is employed to calculate a field output and weighting coefficients for the eigenmodes are selected to achieve a specified set of field output characteristics.

Abstract: Transition-metal doped Li-rich anti-perovskite cathode compositions are provided herein. The Li-rich anti-perovskite cathode compositions have a chemical formula of Li(3-?)M5/mBA, wherein 0<?<3m/(m+1) and ?=3m/(m+1) is the maximum value for the transition metals doping, a chemical formula of Li4-?Ms?/mPC4A, wherein 0<??4m/(m+1) and ?=4m/(m+1) is the maximum value for the transition metals doping, or a combination thereof, wherein M is a transition metal, B is a divalent anion, and A is a monovalent anion. Also provided herein, are methods of making the Li-rich anti-perovskite cathode compositions, and uses of the Li-rich anti-perovskite cathode compositions.

Abstract: Provided is a method of displaying and controlling a plurality of sub-screens on a display apparatus. A plurality of sub-screens of a preset number are displayed on a screen of the display apparatus, and the sub-screens are respectively bound to different input devices, and a control instruction sent from the input devices to the display apparatus independently controls only a sub-screen bound to a particular input device, and does not affect other sub-screens that are not bound to the particular input device. A user of a display may use various services at the same time via the plurality of independent sub-screens displayed on the screen of the display apparatus, and a plurality of users may share a large screen of the display apparatus and view respectively desired content at the same time.

Abstract: A method for extracting a critical dimension of a semiconductor nanostructure. The method includes: 1) determining a value range for each parameter to be extracted, whereby generating an electronic spectra database, and employing training spectra and support vector machine (SVM) training networks for training of SVMs; 2) employing the SVMs after training to map measured spectra to yield a corresponding electronic spectra database; and 3) employing a searching algorithm to search for an optimum simulation spectrum in the corresponding electronic spectra database, simulation parameters corresponding to the simulation spectrum being the critical dimension of the semiconductor nanostructure to be extracted.

Abstract: A method for extracting a critical dimension of a semiconductor nanostructure. The method includes: 1) determining a value range for each parameter to be extracted, whereby generating an electronic spectra database, and employing training spectra and support vector machine (SVM) training networks for training of SVMs; 2) employing the SVMs after training to map measured spectra to yield a corresponding electronic spectra database; and 3) employing a searching algorithm to search for an optimum simulation spectrum in the corresponding electronic spectra database, simulation parameters corresponding to the simulation spectrum being the critical dimension of the semiconductor nanostructure to be extracted.