Abstract: A high-strength steel structure joint connection device includes a device body and a connection seat disposed on two opposite side surfaces of the device body. An inner locking block fixedly connected to the side surface of the device body is disposed inside the connection seat. A steel structure body is inserted between the connection seat and the inner locking block. The steel structure body and the connection seat are detachably and fixedly connected through a positioning mechanism. The high-strength steel structure joint connection device can effectively achieve firm connection of steel structure members, ensure structural stability and improve load-bearing capacity under seismic action or in low-temperature environments, while being suitable for various complex structural forms and facilitating installation and disassembly.