Abstract: The present invention is a single-use ergonomic chalice that has the ability to store both a liquid and a wafer commonly served during the religious ceremony known as Communion. The present invention comprises an ergonomic cup and a cup lid. The ergonomic cup is shaped to easily fit into the fingers or the hand of an individual using the ergonomic cup. Also, the fluid is stored within the ergonomic cup. The cup lid should store the wafer. The present invention may comprise multiple embodiments. Each embodiment is configured to have the cup lid attach to the ergonomic cup. A first embodiment has each the cup lid and the ergonomic cup hermetically sealed with only a single seal. A second embodiment has a seal for each the cup lid and the ergonomic cup. The cup lid may also serve as a supplemental base support for the ergonomic cup.

Abstract: Hydroxylated nebivolol metabolites increase NO release from human endothelial cell preparations in a concentration dependent fashion following acute administration. In addition, hydroxylated nebivolol metabolites, including but not limited to 4-hydroxy-6,6?difluoro-, 4-hydroxy-5-phenol-6,6?difluoro-, and 4-hydroxy-8-pheno-6,6?difluoro-, have the ability to increase the capacity for NO release in human endothelial cells following chronic administration. This invention provides hydroxylated nebivolol metabolites and compositions comprising nebivolol and/or at least one hydroxylated metabolite of nebivolol and/or at least one additional compound used to treat cardiovascular diseases or a pharmaceutically acceptable salt thereof.

Abstract: Hydroxylated nebivolol metabolites increase NO release from human endothelial cell preparations in a concentration dependent fashion following acute administration. In addition, hydroxylated nebivolol metabolites, including but not limited to 4-hydroxy-6,6?difluoro-, 4-hydroxy-5-phenol-6,6?difluoro-, and 4-hydroxy-8-pheno-6,6?difluoro-, have the ability to increase the capacity for NO release in human endothelial cells following chronic administration. This invention provides hydroxylated nebivolol metabolites and compositions comprising nebivolol and/or at least one hydroxylated metabolite of nebivolol and/or at least one additional compound used to treat cardiovascular diseases or a pharmaceutically acceptable salt thereof.