Abstract: In the field of biomedical technology, a PIWI-interacting RNA piR-hsa-211106 is used to prepare a targeted therapeutic drug for inhibiting proliferation of lung adenocarcinoma cells. A mechanism is as follows: after the PIWI-interacting RNA piR-hsa-211106 is constructed into an agonist or a transformant, the agonist or the transformant inhibits a tricarboxylic acid cycle process by down-regulating an expression of a pyruvate carboxylase, inhibits an energy metabolism, promotes apoptosis of the lung adenocarcinoma cells, thus inhibits growth of the lung adenocarcinoma. The PIWI-interacting RNA piR-hsa-211106 directly acts on a target site and does not produce toxic and side effects and an off-target phenomenon. Large amounts of analysis and in-vivo and in-vitro experiments show that the PIWI-interacting RNA piR-hsa-211106 has high credibility and a remarkable treatment effect, and provides a new research direction for anti-tumor therapy of lung adenocarcinoma.

Abstract: In examples, provided are decentralized control methods and apparatus for controlling an output of an inverter. Also provided are decentralized control methods and apparatus for controlling demand in islanded microgrids operating with an insufficient distributed energy resource system (DER) power supply. The provided control methods and apparatus can include a power regulator and a voltage-frequency regulator configured to generate supplementary inputs to control the inverter. The power regulator can control an output of the inverter according to a real-time capacity constraint of the DER. The voltage-frequency regulator can control the output of the inverter in a manner that mitigates a voltage-frequency deviation, such as by leveraging load sensitivity.

Abstract: The provided are a method and device for optimizing production scheduling, and a medium. The method includes: determining an apparatus that has a highest apparatus load rate as a bottleneck apparatus to be adjusted, and obtaining a plurality of producible product models corresponding to the bottleneck apparatus to be adjusted and a plurality of bottleneck apparatuses to be allocated that perform co-production with the bottleneck apparatus to be adjusted; determining an apparatus cluster and a product cluster corresponding to the bottleneck apparatus to be adjusted; and obtaining a spare working hour of each bottleneck apparatus to be adjusted and a total surplus working hour thereof, determining an adjustment rate of the bottleneck apparatus to be adjusted according to the spare working hour, and allocating working hours of the producible product models based on the adjustment rate and the total surplus working hour.

Abstract: This application provides a battery cover color change method applicable to an electronic device and the electronic device. The electronic device includes an application and a battery cover. The method includes: sending audio data to an audio playing process by the application; in an audio playing process, obtaining color change data based on the first audio data, where the color change data corresponds to rhythms of the first audio data; and playing the first audio data while the battery cover changes colors in accordance with the rhythms of the first audio data driven by the color change data.

Abstract: A diamond joined body is a diamond joined body including a hard substrate and a polycrystalline diamond layer arranged on the hard substrate, wherein an area ratio of carbon grains in a region of the hard substrate is less than 0.03%, the region being a region enclosed by an interface between the hard substrate and the polycrystalline diamond layer and an imaginary line x in a cross section parallel to a normal direction of the interface, the imaginary line x being parallel to the interface on the hard substrate side and having a distance of 500 ?m from the interface.

Abstract: A method and system for controlling a device includes training a low-level policy to form a trained low-level policy and a low-level value function to form a trained goal conditioned value function, wherein training is performed using a static data set using goal conditioned episodes, training a high-level goal planner having high level goals having high-level sub-goals corresponding to a plurality of future time steps using the low-level value function to maximize a cumulative reward over the sub-goals for the plurality of future time steps so that the sub-goals are reachable by the low-level policy, obtaining an observation of a device, and generating an executable action using the low-level policy and the high-level goal planner and operating the device with the executable action.

Abstract: Systems and methods for pessimistic offline reinforcement learning are described herein. In one example, a method for performing offline reinforcement learning determines when sampled states are out of distribution, assigns high probability weights to the sampled states that are out of distribution, generates a fitted Q-function by solving an optimization problem with a minimization term and a maximization term, estimates a Q-value using the fitted Q-function by estimating the overall expected reward assuming the agent is in the present state and performs a present action, and updates the policy according to an existing reinforcement learning algorithm. The minimization term penalizes an overall expected reward when a present state is out of distribution. The maximization term cancels the minimization term when the present state is an in-distribution state.

Abstract: A non-invasive blood glucose detection device and a measurement method based on a multi-technology integration is provided according to the disclosure. The device combines a near-infrared spectroscopy non-invasive blood glucose detection technology with a non-invasive blood glucose detection technology based on optical polarimetry, thus improving the detection sensitivity and accuracy, simultaneously inhibiting the influence of human background and individual differences. The AOTF can be used to achieve tunable light splitting and the output lights have two orthogonal linearly polarized light characteristics. The hardware for implementing the two methods are combined. Thus, the device has the advantages of simple structure, strong anti-interference ability and low cost. In addition, it combines the two methods on software by adopting a random forest algorithm and a data fusion algorithm, which effectively improves the prediction accuracy of non-invasive blood glucose concentration.

Abstract: A non-invasive blood glucose detection device and a measurement method based on a multi-technology integration is provided according to the disclosure. The device combines a near-infrared spectroscopy non-invasive blood glucose detection technology with a non-invasive blood glucose detection technology based on optical polarimetry, thus improving the detection sensitivity and accuracy, simultaneously inhibiting the influence of human background and individual differences. The AOTF can be used to achieve tunable light splitting and the output lights have two orthogonal linearly polarized light characteristics. The hardware for implementing the two methods are combined. Thus, the device has the advantages of simple structure, strong anti-interference ability and low cost. In addition, it combines the two methods on software by adopting a random forest algorithm and a data fusion algorithm, which effectively improves the prediction accuracy of non-invasive blood glucose concentration.

Abstract: A diamond joined body is a diamond joined body including a hard substrate and a polycrystalline diamond layer arranged on the hard substrate, wherein an area ratio of carbon grains in a region of the hard substrate is less than 0.03%, the region being a region enclosed by an interface between the hard substrate and the polycrystalline diamond layer and an imaginary line x in a cross section parallel to a normal direction of the interface, the imaginary line x being parallel to the interface on the hard substrate side and having a distance of 500 ?m from the interface.