Abstract: The present invention relates to a process for the preparation of 4-aminobenzoamidine (4-AMBA) salts of general formula (I) preferably the salts thereof with hydrochloric or hydrobromic acid, particularly preferred the dichloride salt.

Abstract: One of the embodiments of the present disclosure relates to a method for PARP reduction.

Abstract: The present invention relates to a process for the preparation of 4-aminobenzoamidine (4-AMBA) salts of general formula (I) preferably the salts thereof with hydrochloric or hydrobromic acid, particularly preferred the dichloride salt.

Abstract: This invention relates to a novel method for the preparation of 3-oxo-tetrahydrofuran comprising oxidizing 3-hydroxy-tetrahydrofuran in the presence of a catalytic amount of 2,2,6,6-tetramethyl-piperidine-N-oxyl (TEMPO) with trichloroisocyanuric acid.

Abstract: The invention discloses an adaptive phase shift method in a multi-carrier system, comprising: generating a group of one or more new phase values for corresponding one or more phase shift carriers, PSCs, based on quantization phase values; calculating and comparing a backward maximum power in an evaluation path with the group of one or more new phase values in one timeslot and a forward maximum power in a working path with current phase values in the timeslot; and adjusting phase of the PSCs based on the group of one or more new phase values if the calculated backward maximum power is less than the calculated forward maximum power. An adaptive phase shift apparatus is also disclosed. With the invention, complexity of the implementation is reduced and a small DPS block resource, low Hardware cost, low power consumption is also achieved.

Abstract: The invention discloses an adaptive phase shift method in a multi-carrier system, comprising: generating a group of one or more new phase values for corresponding one or more phase shift carriers, PSCs, based on quantization phase values; calculating and comparing a backward maximum power in an evaluation path with the group of one or more new phase values in one timeslot and a forward maximum power in a working path with current phase values in the timeslot; and adjusting phase of the PSCs based on the group of one or more new phase values if the calculated backward maximum power is less than the calculated forward maximum power. An adaptive phase shift apparatus is also disclosed. With the invention, complexity of the implementation is reduced and a small DPS block resource, low Hardware cost, low power consumption is also achieved.

Abstract: This invention relates to a novel method for the preparation of 3-oxo-tetrahydrofuran comprising oxidizing 3-hydroxy-tetrahydrofuran in the presence of a catalytic amount of 2,2,6,6-tetramethyl-piperidine-N-oxyl (TEMPO) with trichloroisocyanuric acid.

Abstract: This invention relates to a novel method for the synthesis of 2,4-dichloro-5-trifluoromethyl-pyrimidine useful as intermediate in the manufacture of pharmaceutically active ingredients.

Abstract: The present invention relates to a process for the preparation of 4-aminobenzoamidine (4-AMBA) salts of general formula (I) preferably the salts thereof with hydrochloric or hydrobromic acid, particularly preferred the dichloride salt.

Abstract: This invention relates to the preparation of bis-isoquinoline derivatives of general formula (I) and salts thereof, which possesses multi-drug resistance (MDR) reversal activities. Drug compositions and formulations comprising bis-isoquinoline derivatives of general formula (I) and salts thereof are provided for use as sensitivity enhancers in cancer chemotherapy. Methods for inhibiting MDR by treatment with bis-isoquinoline derivatives are also provided.