Patents by Inventor Jin-sook Ryu

Jin-sook Ryu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230129721
    Abstract: The present invention relates to: a composition for stabilizing a radiopharmaceutical, the composition comprising a vitamin B compound as an active component; and a radiopharmaceutical composition comprising the same. Due to the inclusion of the vitamin B compound, it is possible to stabilize the radiochemical purity of the radioactive compound by inhibiting the radioactive degradation thereof at room temperature as well as at high temperature.
    Type: Application
    Filed: January 19, 2021
    Publication date: April 27, 2023
    Applicants: THE ASAN FOUNDATION, UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION
    Inventors: Sang Ju LEE, Seung Jun OH, Dae Hyuk MOON, Jin-Sook RYU, Jae-Seung KIM, Minyung OH, Yong-il KIM, Jong Jin LEE, Sun Young CHAE, Dong Yun LEE
  • Patent number: 10700387
    Abstract: A carboxymethyl cellulose is provided with a polydispersity index of 10 or more and a weight average molecular weight of 2,000,000 or more in a negative electrode mix slurry. Accordingly, phase stability of the negative electrode mix slurry is improved, achieving improved adhesiveness and low resistance of a negative electrode manufactured therefrom.
    Type: Grant
    Filed: November 14, 2017
    Date of Patent: June 30, 2020
    Assignee: LG CHEM, LTD.
    Inventors: Kwang-Ho Jeong, Ye-Cheol Rho, Jin-Sook Ryu, Je-Young Kim, Jung-Woo Yoo
  • Patent number: 10525151
    Abstract: A method for preparing a radiopharmaceutical and, specifically, a method for preparing an organic fluoride-aliphatic compound usable as a radiopharmaceutical, a method for purifying the prepared organic fluoride-aliphatic compound, and a method for preparing a radiopharmaceutical by using a cassette comprising a backdraft preventing reaction container. A method for preparing an organic fluorinated aliphatic compound includes allowing a fluorine salt to react with a leaving group-containing aliphatic compound by using a multifunctional solvent represented by the following Chemical Formula 1 to obtain an aliphatic compound labeled with [18F] fluoride substituting for the leaving group. The organic fluoride-aliphatic compound can be prepared and purified through even a simple process at high yield, high efficiency, and high purity, and the radiopharmaceutical can be safely prepared without damage to a synthetic apparatus.
    Type: Grant
    Filed: November 6, 2015
    Date of Patent: January 7, 2020
    Assignee: THE ASAN FOUNDATION
    Inventors: Sang-ju Lee, Seung-jun Oh, Dae-hyuk Moon, Jin-sook Ryu, Jae-seung Kim, Jong-jin Lee
  • Publication number: 20180138557
    Abstract: A carboxymethyl cellulose is provided with a polydispersity index of 10 or more and a weight average molecular weight of 2,000,000 or more in a negative electrode mix slurry. Accordingly, phase stability of the negative electrode mix slurry is improved, achieving improved adhesiveness and low resistance of a negative electrode manufactured therefrom.
    Type: Application
    Filed: November 14, 2017
    Publication date: May 17, 2018
    Inventors: Kwang-Ho Jeong, Ye-Cheol Rho, Jin-Sook Ryu, Je-Young Kim, Jung-Woo Yoo
  • Publication number: 20170319720
    Abstract: A method for preparing a radiopharmaceutical and, specifically, a method for preparing an organic fluoride-aliphatic compound usable as a radiopharmaceutical, a method for purifying the prepared organic fluoride-aliphatic compound, and a method for preparing a radiopharmaceutical by using a cassette comprising a backdraft preventing reaction container. A method for preparing an organic fluorinated aliphatic compound includes allowing a fluorine salt to react with a leaving group-containing aliphatic compound by using a multifunctional solvent represented by the following Chemical Formula 1 to obtain an aliphatic compound labeled with [18F] fluoride substituting for the leaving group. The organic fluoride-aliphatic compound can be prepared and purified through even a simple process at high yield, high efficiency, and high purity, and the radiopharmaceutical can be safely prepared without damage to a synthetic apparatus.
    Type: Application
    Filed: November 6, 2015
    Publication date: November 9, 2017
    Inventors: Sang-ju LEE, Seung-jun OH, Dae-hyuk MOON, Jin-sook RYU, Jae-seung KIM, Jong-jin LEE
  • Patent number: 9133143
    Abstract: The present invention relates to (3-fluoro-2-hydroxy)propyl-functionalized aryl derivatives or to the pharmaceutically acceptable salt thereof, to a method for preparing same, and to a pharmaceutical composition containing same as active ingredients for the diagnosis or treatment of neurodegenerative brain diseases. The aryl derivatives of the present invention are (3-fluoro-2-hydroxy)propyl-functionalized to increase the polarity thereof, and therefore the drugs containing the aryl derivatives can easily permeate into the cerebrovascular membrane, thus increasing the effectiveness of the drugs. As the aryl derivatives of the present invention strongly bind to ?-amyloid, the aryl derivatives, when labeled with radioisotope, can be used as a diagnostic agent for non-invasively diagnosing early Alzheimer's disease.
    Type: Grant
    Filed: September 14, 2010
    Date of Patent: September 15, 2015
    Assignee: FUTURECHEM CO., LTD.
    Inventors: Dae-Yoon Chi, Byoung-Se Lee, Sirion Uthaiwan, So-Young Chu, Yu-Jin Bae, Chansoo Park, Dae-Hyuk Moon, Jin-Sook Ryu, Jae-Seung Kim, Seung-Jun Oh
  • Patent number: 8913547
    Abstract: Disclosed is a method for pairing terminals using a dummy terminal, the method including selecting at least one terminal from several, pairing a channel being used by the at least one terminal with data of a dummy terminal, receiving a measurement report message from the at least one terminal, adjusting power of the at least one terminal based upon the measurement report message, and pairing the at least one terminal with another terminal so as to use a channel being used by the at least one terminal together with the another terminal if the at least one terminal is suitable for pairing.
    Type: Grant
    Filed: March 30, 2010
    Date of Patent: December 16, 2014
    Assignee: LG Electronics Inc.
    Inventors: Ji-Woong Lee, Jin-Sook Ryu, Yung-Mi Kim
  • Publication number: 20140039074
    Abstract: The invention generally relates to the preparation of 18F-labeled radiopharmaceuticals. In particular, this invention relates to the advanced processes for an efficient eiution of [18F]fluoride trapped in a cartridge filled with quaternary ammonium polymer which comprises inert non-basic and non-nucleophilic counter anions. The said methods and polymer cartridges allow the rapid preparation of suitable [18F]fluoride solution, which is also less basic to reduce the formation of byproducts, finally to increase radiochemical yield and purity of 18F-radiopharmaceuticals.
    Type: Application
    Filed: September 6, 2011
    Publication date: February 6, 2014
    Applicant: PIRAMAL IMAGING SA
    Inventors: Dae Yoon Chi, Byoung Se Lee, Sang Ju Lee, Jin-Sook Ryu, Seung Ju Oh
  • Patent number: 8615246
    Abstract: The present invention provides a method for receiving information on a network configuration. The present invention is to allow a terminal to acquire accurate information on a neighbor cell. Furthermore, the present invention is to remove duplicated information from the information message on a neighbor cell, for instance, Neighboring Cell Information, thereby allowing an effective configuration thereof and preventing from using network resources wastefully.
    Type: Grant
    Filed: November 25, 2009
    Date of Patent: December 24, 2013
    Assignee: LG Electronics Inc.
    Inventors: Jin-Sook Ryu, Ji-Woong Lee, Yung-Mi Kim
  • Patent number: 8497260
    Abstract: 2-arylbenzothiophene derivatives or pharmaceutically acceptable salts thereof, a preparation method thereof, and a pharmaceutical composition for the diagnosis or treatment of degenerative brain disease containing the same as an active ingredient. Since the 2-arylbenzothiophene derivatives of Formula 1 have a relatively high binding affinity for ?-amyloid, they can be used as diagnostic reagents for diagnosing Alzheimer's disease at an early stage by non-invasive techniques when they are labeled with radioisotopes: wherein R1-R4, V, W, X, Y and Z are as defined in the Detailed Descript of the specification. Further, when the pharmaceutical composition containing the 2-arylbenzothiophene derivative binds with a low-molecular weight ?-amyloid peptide binding compound, generation of malignant high-molecular weight ?-amyloid deposits is minimized. Accordingly, the pharmaceutical composition can be used as a therapeutic agent of degenerative brain disease such as Alzheimer's disease.
    Type: Grant
    Filed: October 15, 2009
    Date of Patent: July 30, 2013
    Assignee: Industry-University Cooperation Foundation Sogang University
    Inventors: Dae Yoon Chi, Byoung Se Lee, Youjung Jung, Uthaiwan Sirion, Yoo Jin Lim, Yu Jin Bae, Heejun Kim, So Young Chu, Dae Hyuk Moon, Jin-Sook Ryu, Jae Seung Kim, Seung Jun Oh
  • Publication number: 20120238740
    Abstract: The present invention provides novel and advantageous processes for preparing and purifying pharmaceuticals The processes comprise a nucleophilic reaction wherein a modified leaving group LM, which has increased lipophilicity, of a vector in a nucleophilic reaction which offers a convenient and time-saving way to purify the product from non-reacted precursors vector-LM and by-products LM.
    Type: Application
    Filed: July 6, 2010
    Publication date: September 20, 2012
    Applicant: BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: Keith Graham, Mathias Berndt, Dae Yoon Chi, Byoung Se Lee, Sandip S. Shinde, Hee Seup Kil, Sang Ju Lee, Jin-Sook Ryu, Seung Jun Oh
  • Publication number: 20120214994
    Abstract: The present invention relates to (3-fluoro-2-hydroxy)propyl-functionalized aryl derivatives or to the pharmaceutically acceptable salt thereof, to a method for preparing same, and to a pharmaceutical composition containing same as active ingredients for the diagnosis or treatment of neurodegenerative brain diseases. The aryl derivatives of the present invention are (3-fluoro-2-hydroxy)propyl-functionalized to increase the polarity thereof, and therefore the drugs containing the aryl derivatives can easily permeate into the cerebrovascular membrane, thus increasing the effectiveness of the drugs. As the aryl derivatives of the present invention strongly bind to ?-amyloid, the aryl derivatives, when labeled with radioisotope, can be used as a diagnostic agent for non-invasively diagnosing early Alzheimer's disease.
    Type: Application
    Filed: September 14, 2010
    Publication date: August 23, 2012
    Inventors: Dae-Yoon Chi, Byoung-Se Lee, Sirion Uthaiwan, So-Young Chu, Yu-Jin Bae, Chansoo Park, Dae-Hyuk Moon, Jin-Sook Ryu, Jae-Seung Kim, Seung-Jun Oh
  • Publication number: 20110312362
    Abstract: Disclosed is a method for pairing terminals using a dummy terminal, the method including selecting at least one terminal from several, pairing a channel being used by the at least one terminal with data of a dummy terminal, receiving a measurement report message from the at least one terminal, adjusting power of the at least one terminal based upon the measurement report message, and pairing the at least one terminal with another terminal so as to use a channel being used by the at least one terminal together with the another terminal if the at least one terminal is suitable for pairing.
    Type: Application
    Filed: March 30, 2010
    Publication date: December 22, 2011
    Inventors: Ji-Woong Lee, Jin-Sook Ryu, Yung-Mi Kim
  • Publication number: 20110294536
    Abstract: The present invention provides a method for receiving information on a network configuration. The present invention is to allow a terminal to acquire accurate information on a neighbor cell. Furthermore, the present invention is to remove duplicated information from the information message on a neighbor cell, for instance, Neighboring Cell Information, thereby allowing an effective configuration thereof and preventing from using network resources wastefully.
    Type: Application
    Filed: November 25, 2009
    Publication date: December 1, 2011
    Inventors: Jin-Sook Ryu, Ji-Woong Lee, Yung-Mi Kim
  • Publication number: 20110112293
    Abstract: The present invention provides novel and advantageous processes for preparing and purifying chemical compounds such as pharmaceuticals. The processes comprise a nucleophilic substitution reaction with a moiety X wherein the leaving group L of a substrate S in the reaction is covalently attached to a purification moiety M. This concept offers a convenient and lime-saving way to purity the desired product S-X from non-reacted precursors S-L-M and by-products L-M.
    Type: Application
    Filed: April 9, 2009
    Publication date: May 12, 2011
    Applicant: BAYER SCHERING PHARMA AKTIENGESELLSCHAFT
    Inventors: John Cyr, Ananth Srinivasan, Mathias Berndt, Keith Graham, Dae Yoon Chi, Byoung Se Lee, So Young Chu, Song-Yi Lim, Sang Ju Lee, Jin-Sook Ryu, Seung Jun Oh
  • Patent number: 7847092
    Abstract: The present invention relates to a method for preparation of organofluoro compounds containing radioactive isotope fluorine-18. More particularly, the present invention relates to a method for preparation of primary or secondary organofluoro compound by reacting fluorine salt containing radioactive isotope fluorine-18 with primary or secondary alkyl halide or primary or secondary alkyl sulfonate in the presence of alcohol of Chemical Formula 1 as a solvent to obtain high yield of organofluoro compound. Synthesis reaction according to the present invention may be carried out under mild condition to give high yield of the organofluoro compounds and the reaction time is decreased, and thereby is suitable for the mass production of the organofluoro compounds.
    Type: Grant
    Filed: December 9, 2005
    Date of Patent: December 7, 2010
    Assignees: FutureChem Co., Ltd., The Asan Foundation
    Inventors: Dae Hyuk Moon, Dae Yoon Chi, Dong Wook Kim, Seung Jun Oh, Jin-sook Ryu
  • Publication number: 20100261727
    Abstract: 2-arylbenzothiophene derivatives or pharmaceutically acceptable salts thereof, a preparation method thereof, and a pharmaceutical composition for the diagnosis or treatment of degenerative brain disease containing the same as an active ingredient. Since the 2-arylbenzothiophene derivatives of Formula 1 have a relatively high binding affinity for ?-amyloid, they can be used as diagnostic reagents for diagnosing Alzheimer's disease at an early stage by non-invasive techniques when they are labeled with radioisotopes: wherein R1-R4, V, W, X, Y and Z are as defined in the Detailed Descript of the specification. Further, when the pharmaceutical composition containing the 2-arylbenzothiophene derivative binds with a low-molecular weight ?-amyloid peptide binding compound, generation of malignant high-molecular weight ?-amyloid deposits is minimized. Accordingly, the pharmaceutical composition can be used as a therapeutic agent of degenerative brain disease such as Alzheimer's disease.
    Type: Application
    Filed: October 15, 2009
    Publication date: October 14, 2010
    Inventors: Dae Yoon Chi, Byoung Se Lee, Youjung Jung, Uthaiwan Sirion, Yoo Jin Lim, Yu Jin Bae, Heejun Kim, So Young Chu, Dae Hyuk Moon, Jin-Sook Ryu, Jae Seung Kim, Seung Jun Oh
  • Publication number: 20100113763
    Abstract: The present invention relates to a method for preparation of organofluoro compounds containing radioactive isotope fluorine-18. More particularly, the present invention relates to a method for preparation of organofluoro compound [18F]florbetaben or [18F]AV-45 having <Chemistry Formula 11> and <Chemistry Formula 12>, respectively, by reacting fluorine salt containing radioactive isotope fluorine-18 with alkyl halide or alkyl sulfonate in the presence of alcohol of Chemistry Formula 1 as a solvent to obtain high yield of organofluoro compound. Synthesis reaction according to the present invention may be carried out under mild condition to give high yield of the organofluoro compounds and the reaction time is decreased, and thereby is suitable for the mass production of the organofluoro compounds.
    Type: Application
    Filed: October 26, 2009
    Publication date: May 6, 2010
    Applicants: FUTURECHEM CO., LTD., THE ASAN FOUNDATION
    Inventors: Dae Hyuk MOON, Dae Yoon CHI, Dong Wook KIM, Seung Jun OH, Jin-sook RYU
  • Publication number: 20080171863
    Abstract: The present invention relates to a method for preparation of organofluoro compounds containing radioactive isotope fluorine-18. More particularly, the present invention relates to a method for preparation of organofluoro compound by reacting fluorine salt containing radioactive isotope fluorine-18 with alkyl halide or alkyl sulfonate in the presence of alcohol of Chemistry (FIG. 1) as a solvent to obtain high yield of organofluoro compound. Synthesis reaction according to the present invention may be carried out under mild condition to give high yield of the organofluoro compounds and the reaction time is decreased, and thereby is suitable for the mass production of the organofluoro compounds.
    Type: Application
    Filed: December 9, 2005
    Publication date: July 17, 2008
    Applicants: FUTURECHEM CO., LTD., THE ASAN FOUNDATION
    Inventors: Dae Hyuk Moon, Dae Yoon Chi, Dong Wook Kim, Seung Jun Oh, Jin-sook Ryu
  • Publication number: 20030120046
    Abstract: The present invention relates to a complex comprising one or more radioisotopes selected from the group consisting of 99mTc, 188Re and 186Re chelated to a glucose derivative having an intramolecular nitrogen or sulfur atom, which is very useful as tumor diagnostic agents. It also relates to a kit for the preparation thereof comprising the glucose derivative and a reducing agent.
    Type: Application
    Filed: September 20, 2002
    Publication date: June 26, 2003
    Inventors: Hee-Kyung Lee, Dae-Hyuk Moon, Jin-Sook Ryu, Jae-Seung Kim, Seung-Jun Oh