Patents by Inventor Jinun-Ban Yeh

Jinun-Ban Yeh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF PRODUCING NARONAPRIDE TRIHYDRATE
    Publication number: 20210355116
    Abstract: Provided herein are methods of producing the trihydrate form of (3S, 4R, 3?R)-6-[4-(4-amino-5-chloro-2-methoxy-benzoylamino)-3-methoxy-piperidin-1-yl]-hexanoic acid 1-azabicyclo[2.2.2]oct-3?-yl ester di-hydrochloride salt.
    Type: Application
    Filed: April 30, 2021
    Publication date: November 18, 2021
    Inventors: Pascal Jean DRUZGALA, Peter MILNER, Jien Heh TIEN, Jinun-Ban YEH, Yen-Wei LI, Yen-Chi SU
  • Preparation of Duloxetine® hydrochloride using optically active methylhydroxylaminopropanol compound as an intermediate
    Patent number: 8957227
    Abstract: The present invention provides a process for preparing duloxetine hydrochloride with higher yield and lower cost.
    Type: Grant
    Filed: August 29, 2013
    Date of Patent: February 17, 2015
    Assignee: SCI Pharmtech, Inc.
    Inventors: Bo-Fong Chen, Feng-Ju Lu, Jinun-Ban Yeh, Wei-Chyun Wong, Feng-hsu Li, Yen-Wei Li, Yeh-Chi Su
  • PREPARATION OF DULOXETINE HYDROCHLORIDE USING OPTICALLY ACTIVE METHYLHYDROXYLAMINOPROPANOL COMPOUND AS AN INTERMEDIATE
    Publication number: 20140005414
    Abstract: The present invention provides a process for preparing duloxetine hydrochloride with higher yield and lower cost.
    Type: Application
    Filed: August 29, 2013
    Publication date: January 2, 2014
    Applicant: SCI Pharmtech, Inc.
    Inventors: Bo-Fong Chen, Feng-Ju Lu, Jinun-Ban Yeh, Wei-Chyun Wong, Feng-hsu Li, Yen-Wei Li, Yeh-Chi Su
  • Process for preparing -methyl--hydroxyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine derivative
    Patent number: 8614336
    Abstract: The present invention provides a process for preparing a N-methyl-N-hydroxyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine compound. The present invention also provides a process for preparing (S)-(+)-N-methyl-3-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine with higher yield and low treatment cost, which includes the preparation of the N-methyl-N-hydroxyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine compound.
    Type: Grant
    Filed: March 5, 2010
    Date of Patent: December 24, 2013
    Assignee: SCI Pharmtech, Inc.
    Inventors: Bo-Fong Chen, Jinun-Ban Yeh, Wei-Chyun Wong
  • Process for preparing ()-(+)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine by using optically active methylhydroxylaminopropanol compound as intermediate
    Patent number: 8530674
    Abstract: The present invention provides (S)-methylhydroxylaminopropanol compound as an intermediate in preparation of (S)-(+)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine. The present invention also provides a process for preparing (S)-(+)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine with higher yield and lower cost by using the (S)-methylhydroxylaminopropanol compound as an intermediate.
    Type: Grant
    Filed: May 6, 2010
    Date of Patent: September 10, 2013
    Assignee: SCI Pharmtech, Inc.
    Inventors: Bo-Fong Chen, Feng-Ju Lu, Jinun-Ban Yeh, Wei-chyun Wong
  • METHOD FOR TREATING HEPATITIS B
    Publication number: 20130123204
    Abstract: The disclosure provides a method for treating hepatitis B, including: administering an effective amount of proanthocyanidins wherein the formula of a monomer of the proanthocyanidins is shown as Formula (I): wherein R1 is OCH3, R2 is OH and R3 is H, or R1 is OH and R2 and R3 both are H, or R1 and R2 both are OH and R3 is H, or R1, R2 and R3 all are OH, and R4 is 3-(?)-OH, 3-(?)-OH, 3-(?)-O-sugar or 3-(?)-O-sugar. Bonding between adjacent monomers take place at C4, C8 Carbon-carbon bond or C2, C7 oxygen bond of A type or C4, C8 or C4, C6 Carbon-carbon bond of B type or C type of proanthocyanidins. And the polymerized number is from 2 to 30.
    Type: Application
    Filed: January 7, 2013
    Publication date: May 16, 2013
    Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Lain-Tze LEE, Shau-Feng CHANG, Chia-Yu LIN, Hui-Yen WU, Shu-Feng CHEN, Jinun-Ban YEH
  • Optically active methylhydroxylaminopropanol derivative and its use as intermediate for preparation of ()-(-)-3-methylamino-1-(-2-thienyl)propan-1-ol
    Patent number: 8420832
    Abstract: The present invention provides an (S)-methylhydroxylaminopropanol compound and the (S)-methylhydroxylaminopropanol compound of the present invention is used as an intermediate for preparation of (S)-(?)-3-methylamino-1-(2-thienyl)propan-1-ol, which is an intermediate for preparation of (S)-(+)-N-methyl-3-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine oxalate. The present invention also provides a process for preparing (S)-(+3-methylamino-1-(2-thienyl)propan-1-ol with higher yield and lower cost, wherein the (S)-methylhydroxylaminopropanol compound is used as an intermediate.
    Type: Grant
    Filed: March 30, 2012
    Date of Patent: April 16, 2013
    Assignee: Sci Pharmtech, Inc.
    Inventors: Bo-Fong Chen, Jinun-Ban Yeh, Weichyun Wong
  • Method for preparing atomoxetine
    Patent number: 8299305
    Abstract: The present invention provides an efficient method for preparing atomoxetine in high yield. (R)-methylhydroxylaminopropanol compound of formula (II) in the present invention is used as an intermediate without the need for resolution processes.
    Type: Grant
    Filed: June 29, 2010
    Date of Patent: October 30, 2012
    Assignee: Sci Pharmtech, Inc.
    Inventors: Bo-Fong Chen, Yan-Wei Li, Jinun-Ban Yeh, Wei-Chyun Wong
  • OPTICALLY ACTIVE METHYLHYDROXYLAMINOPROPANOL DERIVATIVE AND ITS USE AS INTERMEDIATE FOR PREPARATION OF (S)-(-)-3-METHYLAMINO-1-(-2-THIENYL)PROPAN-1-OL
    Publication number: 20120190869
    Abstract: The present invention provides an (S)-methylhydroxylaminopropanol compound and the (S)-methylhydroxylaminopropanol compound of the present invention is used as an intermediate for preparation of (S)-(?)-3-methylamino-1-(2-thienyl)propan-1-ol, which is an intermediate for preparation of (S)-(+)-N-methyl-3-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine oxalate. The present invention also provides a process for preparing (S)-(+3-methylamino-1-(2-thienyl)propan-1-ol with higher yield and lower cost, wherein the (S)-methylhydroxylaminopropanol compound is used as an intermediate.
    Type: Application
    Filed: March 30, 2012
    Publication date: July 26, 2012
    Applicant: SCI PHARMTECH, INC.
    Inventors: Bo-Fong CHEN, Jinun-Ban YEH, Weichyun WONG
  • Optically active methylhydroxylaminopropanol compound and its use as intermediate for preparation of ()-(?)-3-methylamino-1-(2-thienyl)propan-1-ol
    Patent number: 8168805
    Abstract: The present invention provides an (S)-methylhydroxylaminopropanol derivative and the (S)-methylhydroxylaminopropanol derivative of the present invention is used as an intermediate for preparation of (S)-(?)-3-methylamino-1-(2-thienyl)propan-1-ol, which is an intermediate for preparation of (S)-(+)-N-methyl-3-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine oxalate. The present invention also provides a process for preparing (S)-(?)-3-methylamino-1-(2-thienyl)propan-1-ol with higher yield and lower cost, wherein the (S)-methylhydroxylaminopropanol derivative is used as an intermediate.
    Type: Grant
    Filed: May 15, 2008
    Date of Patent: May 1, 2012
    Assignee: SCI Pharmtech, Inc
    Inventors: Bo-Fong Chen, Jinun-Ban Yeh, Weichyun Wong
  • Preparation of (S)-(+)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl) propylamine using optically active methylhydroxylaminopropanol compound as an intermediate
    Patent number: 8148549
    Abstract: The present invention provides a (S)-methylhydroxylaminopropanol derivative as an intermediate for preparation of (S)-(+)-N-methyl-3-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine. The present invention also provides a process for preparing (S)-(+)-N-methyl-3-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine with higher yield and lower cost, wherein the (S)-methylhydroxylaminopropanol derivative is used as an intermediate.
    Type: Grant
    Filed: March 12, 2009
    Date of Patent: April 3, 2012
    Assignee: SCI Pharmtech, Inc.
    Inventors: Bo-Fong Chen, Jinun-Ban Yeh, Wei-Chyun Wong
  • METHOD FOR PREPARING ATOMOXETINE
    Publication number: 20110319664
    Abstract: The present invention provides an efficient method for preparing atomoxetine in high yield. (R)-methylhydroxylaminopropanol compound of formula (II) in the present invention is used as an intermediate without the need for resolution processes.
    Type: Application
    Filed: June 29, 2010
    Publication date: December 29, 2011
    Inventors: Bo-Fong Chen, Yan-Wei Li, Jinun-Ban Yeh, Wei-Chyun Wong
  • PROCESS FOR PREPARING (S)-(+)-N-METHYL-3-(1-NAPHTHYLOXY)-3-(2-THIENYL)PROPYLAMINE BY USING OPTICALLY ACTIVE METHYLHYDROXYLAMINOPROPANOL COMPOUND AS INTERMEDIATE
    Publication number: 20110275835
    Abstract: The present invention provides (S)-methylhydroxylaminopropanol compound as an intermediate in preparation of (S)-(+)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine. The present invention also provides a process for preparing (S)-(+)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine with higher yield and lower cost by using the (S)-methylhydroxylaminopropanol compound as an intermediate.
    Type: Application
    Filed: May 6, 2010
    Publication date: November 10, 2011
    Inventors: Bo-Fong Chen, Feng-Ju Lu, Jinun-Ban Yeh, Wei-chyun Wong
  • Methylhydroxylaminopropanol derivative and its use as intermediate for preparation of 3-methylamino-1-(2-thienyl)propan-1-OL
    Patent number: 7829731
    Abstract: The present invention provides a methylhydroxylaminopropanol derivative and the methylhydroxylaminopropanol derivative of the present invention is used as an intermediate for preparation of 3-methylamino-1-(2-thienyl)propan-1-ol, which is an intermediate for preparation of (+)-(S)—N-methyl-3-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine oxalate. The present invention also provides a process for preparing 3-methylamino-1-(2-thienyl)propan-1-ol with higher yield and lower cost, wherein the methylhydroxylaminopropanol derivative is used as an intermediate.
    Type: Grant
    Filed: October 29, 2007
    Date of Patent: November 9, 2010
    Assignee: SCI Pharmtech, Inc.
    Inventors: Bo-Fong Chen, Jinun-Ban Yeh, Weichyun Wong
  • PREPARATION OF (S)-(+)-N-METHYL-3-(1-NAPHTHYLOXY)-3-(2-THIENYL) PROPYLAMINE USING OPTICALLY ACTIVE METHYLHYDROXYLAMINOPROPANOL DERIVATIVE AS AN INTERMEDIATE
    Publication number: 20100234619
    Abstract: The present invention provides a (S)-methylhydroxylaminopropanol derivative as an intermediate for preparation of (S)-(+)-N-methyl-3-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine. The present invention also provides a process for preparing (S)-(+)-N-methyl-3-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine with higher yield and lower cost, wherein the (S)-methylhydroxylaminopropanol derivative is used as an intermediate.
    Type: Application
    Filed: March 12, 2009
    Publication date: September 16, 2010
    Inventors: Bo-Fong Chen, Jinun-Ban Yeh, Wei-Chyun Wong
  • PROCESS FOR PREPARING N-METHYL-N-HYDROXYL-3-(1-NAPHTHYLOXY)-3-(2-THIENYL)PROPYLAMINE DERIVATIVE
    Publication number: 20100234620
    Abstract: The present invention provides a process for preparing a N-methyl-N-hydroxyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine compound. The present invention also provides a process for preparing (S)-(+)-N-methyl-3-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine with higher yield and low treatment cost, which includes the preparation of the N-methyl-N-hydroxyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine compound.
    Type: Application
    Filed: March 5, 2010
    Publication date: September 16, 2010
    Inventors: Bo-Fong Chen, Jinun-Ban Yeh, Wei-Chyun Wong
  • PHARMACEUTICAL COMPOSITION FOR TREATING HEPATITIS B VIRUS AND HEALTH FOOD PRODUCT HAVING HEPATITIS B VIRUS INHIBITING EFFECTS
    Publication number: 20100168221
    Abstract: The invention provides a pharmaceutical composition for treating hepatitis B, including: an effective amount of proanthocyanidins; and a pharmaceutically acceptable carrier or salt, wherein a formula of the monomer of the proanthocyanidins is shown in the following: , wherein R1 is OCH3, R2 is OH and R3 is H, or R1 is OH and R2 and R3 both are H, or R1 and R2 both are OH and R3 is H, or R1, R2 and R3 all are OH, and R4 is 3-(?)-OH, 3-(?)-OH, 3-(?)-O-sugar or 3-(?)-O-sugar. Bonding between adjacent monomers take place at C4, C8 Carbon-carbon bond or C2, C7 oxygen bond of A type or C4, C8 or C4, C6 Carbon-carbon bond of B type or C type of proanthocyanidins. And the polymerized number is from 2 to 30.
    Type: Application
    Filed: December 29, 2009
    Publication date: July 1, 2010
    Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Lain-Tze LEE, Shau-Feng Chang, Chia-Yu Lin, Hui-Yen Wu, Shu-Feng Chen, Jinun-Ban Yeh
  • Synthetic methods and intermediates for steroisomeric compounds useful for the treatment of gastrointestinal and central nervous system disorders
    Patent number: 7629466
    Abstract: The subject invention provides methods and/or processes for making stereoisomeric compounds of formula (X): wherein the variables are as defined herein, and compositions for the safe and effective treatment of various gastrointestinal disorders including, but not limited to, gastroparesis, gastroesophageal reflux and related conditions. The compounds of the subject invention are also useful in treating a variety of conditions involving the central nervous system.
    Type: Grant
    Filed: April 25, 2008
    Date of Patent: December 8, 2009
    Assignee: ARYx Therapeutics, Inc.
    Inventors: Kolbot By, Jinun-Ban Yeh, Ponny Pang
  • METHYLHYDROXYLAMINOPROPANOL DERIVATIVE AND ITS USE AS INTERMEDIATE FOR PREPARATION OF 3-METHYLAMINO-1-(2-THIENYL)PROPAN-1-OL
    Publication number: 20090112000
    Abstract: The present invention provides a methylhydroxylaminopropanol derivative and the methylhydroxylaminopropanol derivative of the present invention is used as an intermediate for preparation of 3-methylamino-1-(2-thienyl)propan-1-ol, which is an intermediate for preparation of (+)-(S)—N-methyl-3-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine oxalate. The present invention also provides a process for preparing 3-methylamino-1-(2-thienyl)propan-1-ol with higher yield and lower cost, wherein the methylhydroxylaminopropanol derivative is used as an intermediate.
    Type: Application
    Filed: October 29, 2007
    Publication date: April 30, 2009
    Applicant: SCI Pharmtech, Inc.
    Inventors: Bo-Fong Chen, Jinun-Ban Yeh, Weichyun Wong
  • OPTICALLY ACTIVE METHYLHYDROXYLAMINOPROPANOL DERIVATIVE AND ITS USE AS INTERMEDIATE FOR PREPARATION OF (S)-(-)-3-METHYLAMINO-1-(2-THIENYL)PROPAN-1-OL
    Publication number: 20090112001
    Abstract: The present invention provides an (S)-methylhydroxylaminopropanol derivative and the (S)-methylhydroxylaminopropanol derivative of the present invention is used as an intermediate for preparation of (S)-(?)-3-methylamino-1-(2-thienyl)propan-1-ol, which is an intermediate for preparation of (S)-(+)-N-methyl-3-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine oxalate. The present invention also provides a process for preparing (S)-(?)-3-methylamino-1-(2-thienyl)propan-1-ol with higher yield and lower cost, wherein the (S)-methylhydroxylaminopropanol derivative is used as an intermediate.
    Type: Application
    Filed: May 15, 2008
    Publication date: April 30, 2009
    Applicant: SCI Pharmtech, Inc.
    Inventors: Bo-Fong CHEN, Jinun-Ban YEH, Weichyun WONG