Abstract: The present disclosure provides a bispecific antibody including a binding domain that binds to CD112R and a binding domain that binds to TIGIT, and the binding domain that binds to CD112R includes: HCDR1, HCDR2 and HCDR3 of the amino acid sequence set forth in SEQ ID NO: 1, and/or LCDR1, LCDR2 and LCDR3 of the amino acid sequence set forth in SEQ ID NO: 2; and the HCDR1, HCDR2, HCDR3, LCDR1, LCDR2 and LCDR3 are defined according to the Kabat, IMGT, Chothia, AbM or Contact numbering system. The present disclosure further provides a polynucleotide encoding the antibody, an expression vector, a host cell and a method for expressing and purifying the antibody, a pharmaceutical composition including the antibody of the present disclosure, and use of the bispecific antibody for treating cancer.

Abstract: The invention relates to a method and to a device for analyzing a sensor data stream, which characterizes a vehicle environment, with respect to a presence of traffic scenarios. The invention further relates to a method for guiding a vehicle. A similarity measure, which indicates the degree of correspondence between a section of the sensor data stream and at least one template stored in a database, is determined by mapping the section of the sensor data stream to the at least one template, preferably by means of dynamic time normalization. The template thereby characterizes a known traffic scenario. The known traffic scenario is assigned to the section of the sensor data stream, if the similarity measure satisfies a predetermined similarity criterion.