Abstract: This present disclosure relates to a highly effective sewage treatment based on regulation and control of directed electron flow and apparatus thereof The apparatus includes an anaerobic fermentation electron generation chamber, a heterotrophic-autotrophic denitrification chamber and an aerobic membrane separation chamber. Low concentrated organic sewage is introduced into anaerobic fermentation electron generation chamber; then, particulate and partly dissolved organic substances are intercepted and absorbed by carrier materials; and extracellular currents generated by microorganism reaction are used in following autotrophic denitrification processing. Micro-/ultra-membrane separation processing is used to improve operation load and solid-liquid separation effect of sewage treatment and thereby effluent could meet the high recycling standards. The directed electron flow is regulated and controlled to enhance nutrients' removal and to reduce sludge yield and fouling rate of membrane.