Abstract: The present disclosure provides genetically modified iPSC-derived ??T cells and their precursors. A double genomic disruption in the suppressor of cytokine signaling 1 (SOCS1) gene and the cytokine-inducible sh2-containing protein (CISH) gene are provided, as is a triple genomic disruption in genes for SOCS1, CISH, and Bcl-2 interacting mediator of cell death (BIM), as is a quadruple genomic disruption in genes for SOCS1, CISH, BIM, and cell surface death receptor (FAS), as is a quintuple genomic disruption in genes for SOCS1, CISH, BIM, ?-2-Microglobulin (B2M), and class II transactivator (CITTA), as is a sextuple genomic disruption in genes for SOCS1, CISH, BIM, B2M, CITTA, and FAS. Also provided is genetically modified iPSC-derived ??T cells and their precursors with improved proliferation and tumor killing activity. Also provided are genetically modified iPSC-derived ??T cells and their precursors further comprising CD19 CAR.

Abstract: An automatically inflatable safety device includes an inflatable safety jacket mounted on a user's body and having an inner face formed with an air valve, and an inflation mechanism mounted on the air valve of the safety jacket to supply air into the safety jacket. Thus, the automatically inflatable safety device is available for traffic vehicles applied in the land (such as the motorcycle) and the water (such as the boat or ship), so that the automatically inflatable safety device has an amphibious effect, thereby greatly enhancing the versatility of the automatically inflatable safety device.