Abstract: The present invention provides compositions and methods of inducing an immune response in a subject in need thereof, comprising administering to the subject an immunologically-effective amount of a live Salmonella Typhi vector comprising a heterologous antigen from a pathogen, wherein the heterologous antigen comprises an outer membrane protein, an antigenic fragment thereof or a variant thereof, wherein the antigen is delivered to a mucosal tissue of the subject by an outer membrane vesicle.

Abstract: The present invention provides compositions and methods of inducing an immune response in a subject in need thereof, comprising administering to the subject an immunologically-effective amount of a live Salmonella Typhi vector comprising a heterologous antigen from a pathogen, wherein the heterologous antigen comprises an outer membrane protein, an antigenic fragment thereof or a variant thereof, wherein the antigen is delivered to a mucosal tissue of the subject by an outer membrane vesicle.

Abstract: Bacterial live vector vaccines represent a vaccine development strategy that offers exceptional flexibility. In the present invention, genes encoding protective antigens of unrelated bacterial, viral, parasitic, or fungal pathogens are expressed in an attenuated bacterial vaccine strain that delivers these foreign antigens to the immune system, thereby eliciting relevant immune responses. Rather than expressing these antigens using only low copy expression plasmids, expression of foreign proteins is accomplished using both low copy expression plasmids in conjunction with chromosomal integrations within the same live vector. This strategy compensates for the inherent disadvantage of loss of gene dosage (versus exclusive plasmid-based expression) by integrating antigen expression cassettes into multiple chromosomal sites already inactivated in an attenuated vector.

Abstract: Bacterial live vector vaccines represent a vaccine development strategy that offers exceptional flexibility. In the present invention, genes encoding protective antigens of unrelated bacterial, viral, parasitic, or fungal pathogens are expressed in an attenuated bacterial vaccine strain that delivers these foreign antigens to the immune system, thereby eliciting relevant immune responses. Rather than expressing these antigens using only low copy expression plasmids, expression of foreign proteins is accomplished using both low copy expression plasmids in conjunction with chromosomal integrations within the same live vector. This strategy compensates for the inherent disadvantage of loss of gene dosage (versus exclusive plasmid-based expression) by integrating antigen expression cassettes into multiple chromosomal sites already inactivated in an attenuated vector.

Abstract: Bacterial live vector vaccines represent a vaccine development strategy that offers exceptional flexibility. In the present invention, genes encoding protective antigens of unrelated bacterial, viral, parasitic, or fungal pathogens are expressed in an attenuated bacterial vaccine strain that delivers these foreign antigens to the immune system, thereby eliciting relevant immune responses. Rather than expressing these antigens using only low copy expression plasmids, expression of foreign proteins is accomplished using both low copy expression plasmids in conjunction with chromosomal integrations within the same live vector. This strategy compensates for the inherent disadvantage of loss of gene dosage (versus exclusive plasmid-based expression) by integrating antigen expression cassettes into multiple chromosomal sites already inactivated in an attenuated vector.

Abstract: Bacterial live vector vaccines represent a vaccine development strategy that offers exceptional flexibility. In the present invention, genes encoding protective antigens of unrelated bacterial, viral, parasitic, or fungal pathogens are expressed in an attenuated bacterial vaccine strain that delivers these foreign antigens to the immune system, thereby eliciting relevant immune responses. Rather than expressing these antigens using only low copy expression plasmids, expression of foreign proteins is accomplished using both low copy expression plasmids in conjunction with chromosomal integrations within the same live vector. This strategy compensates for the inherent disadvantage of loss of gene dosage (versus exclusive plasmid-based expression) by integrating antigen expression cassettes into multiple chromosomal sites already inactivated in an attenuated vector.

Abstract: A multi-interface storage device used in a computer under power off status is disclosed and adapted for transmitting data and communicating with an external electronic device remotely. The multi-interface storage device used in the computer under power off status comprises a transmission interface, an internet interface, a storage unit for storing data and a processing unit. The transmission interface is connected with an electronic device inside the computer, and the internet interface is connected with the external electronic device. The processing unit is connected with the storage unit, the internet interface and the transmission interface for communicating with the external electronic device through the internet interface to enable the external electronic device to store and process the data stored in the storage unit under the power off status of the computer.

Abstract: A method for recording a speaker's voice and operations during a computer aided presentation is disclosed. The method records the speaker's voice to convert into a voice data packet (VDP) when a presentation file, such as a PowerPoint file, is being executed. Once the speaker's operation to the presentation file appears (e.g. skip) in the meantime, the VDP is finished and an operational data is recorded to convert into an operation data packet (ODP), which is arranged after the VDP, while the recording of voice continues and convert into another VDP after the ODP. The VDPs and ODPs are interlacedly and sequentially combined into a presentation record file, which can be synchronously executed with the presentation file for reproducing slides, voice and operations occurring in the then live presentation.

Abstract: A car lock includes an elongated tube to which a first lock hook is fixed and a second lock hook is movably mounted. A connecting member is provided for pivotally interconnecting a locking rod and the elongated tube so that the locking rod can be rotated to a position substantially perpendicular to the elongated tube and an abutting plate, rotatably connected to the locking rod, can be brought into contact with a stereo receiver detachably received in the dashboard of a car. The locking rod passes through a positioning member so that the second lock hook can be inserted into a channel formed in the positioning member when the second lock hook is moved to hook the steering wheel of the car and the locking rod is rotated to a position substantially perpendicular to the elongated tube.