Patents by Inventor Jinzhao Hou

Jinzhao Hou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS OF TREATING AMYOTROPHIC LATERAL SCLEROSIS (ALS)
    Publication number: 20250146000
    Abstract: The present invention relates to small interfering RNA (siRNA) molecules against the SOD1 gene, adeno-associated viral (AAV) vectors encoding siRNA molecules and methods for treating amyotrophic lateral sclerosis (ALS) using the siRNA molecules and AAV vectors.
    Type: Application
    Filed: September 13, 2024
    Publication date: May 8, 2025
    Inventors: Dinah Wen-Yee SAH, Jinzhao Hou, Mathieu E. Nonnenmacher, Pengcheng Zhou, Markus Hossbach, Jochen Deckert
  • Frataxin expression constructs having engineered promoters and methods of use thereof
    Patent number: 12281321
    Abstract: The disclosure relates to compositions and methods for altering, e.g., enhancing, the expression of frataxin (FXN), whether in vitro and/or in vivo including, but not limited to, the exploitation of engineered promoters. Such compositions include delivery via administration of an adeno-associated viral (AAV) particle. The compositions and methods of the present disclosure are useful in the treatment of subjects diagnosed with, or suspected of having Friedreich's ataxia or another neuromuscular or neurological condition resulting from a deficiency in the quantity and/or function of frataxin or associated with decreased expression or protein levels of frataxin.
    Type: Grant
    Filed: September 27, 2019
    Date of Patent: April 22, 2025
    Assignee: Voyager Therapeutics, Inc.
    Inventors: Holger Patzke, Jinzhao Hou, Hongxing Wang, Yanqun Shu, Martin Goulet, Dinah Wen-Yee Sah
  • MODULATORY POLYNUCLEOTIDES
    Publication number: 20250115917
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of modulatory polynucleotides.
    Type: Application
    Filed: July 17, 2024
    Publication date: April 10, 2025
    Inventors: Jinzhao Hou, Mathieu E. Nonnenmacher, Pengcheng Zhou
  • TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS (ALS)
    Publication number: 20250084435
    Abstract: The present invention relates to AAVs encoding a SOD1 targeting polynucleotide which may be used to treat amyotrophic lateral sclerosis (ALS) and/or canine degenerative myelopathy (DM).
    Type: Application
    Filed: July 23, 2024
    Publication date: March 13, 2025
    Inventors: Dinah Wen-Yee SAH, Qingmin CHEN, Joan R. COATES, Holger PATZKE, Jinzhao HOU
  • RECOMBINANT AAV FOR THE GENE THERAPY OF FABRY DISEASE
    Publication number: 20250066812
    Abstract: The present invention provides a polynucleotide and recombinant AAV encoding human alpha galactosidase A. The present invention also provides a method of treating Fabry disease comprising administering the recombinant AAV to a subject in need thereof.
    Type: Application
    Filed: December 30, 2022
    Publication date: February 27, 2025
    Applicant: Skyline Therapeutics Limited
    Inventors: Jinzhao HOU, Ting YU, Jiao YUE, Haiyan JIANG
  • COMPOSITONS AND METHODS FOR THE TREATMENT OF NEUROLOGICAL DISORDERS RELATED TO GLUCOSYLCERAMIDASE BETA DEFICIENCY
    Publication number: 20250049955
    Abstract: The disclosure relates to compositions and methods for altering, e.g., enhancing, the expression of GCase proteins, whether in vitro and/or in vivo. Such compositions include delivery of an adeno-associated viral (AAV) particle. The compositions and methods of the present disclosure are useful in the treatment of subjects diagnosed with, or suspected of having Parkinson Disease or related condition resulting from a deficiency in the quantity and/or function of GBA gene product or associated with decreased expression or protein levels of GCase protein.
    Type: Application
    Filed: November 16, 2022
    Publication date: February 13, 2025
    Inventors: Mathieu Emmanuel NONNENMACHER, Matthew Alan CHILD, Jinzhao HOU, Jiangyu LI, Shaoyong LI, Tyler Christopher MOYER, Wei WANG, Giridhar MURLIDHARAN, Kelly BALES, Jeffrey BROWN, Elisabeth KNOLL, Smita JAGTAP, Yanqun SHU, Adewale ADELUYI, Brett HOFFMAN, Nilesh Navalkishor PANDE, Jeffrey Scott THOMPSON
  • COMPOSITIONS AND METHODS FOR THE TREATMENT OF TAU-RELATED DISORDERS
    Publication number: 20250034559
    Abstract: The disclosure provides compositions and methods for the preparation, manufacture and use of an adeno-associated virus (AAV) particle for the vectorized delivery of an antibody molecule that binds to tau.
    Type: Application
    Filed: November 17, 2022
    Publication date: January 30, 2025
    Inventors: Mathieu Emmanuel NONNENMACHER, Matthew Alan CHILD, Jinzhao HOU, Jiangyu LI, Shaoyong LI, Tyler Christopher MOYER, Wei WANG, Brett FOFFMAN, Elisabeth KNOLL, Yanqun SHU, Nilesh Navalkishor PANDE, Jeffrey Scott THOMPSON
  • AAV CAPSID VARIANTS AND USES THEREOF
    Publication number: 20250011372
    Abstract: The disclosure relates to compositions, formulations, and methods for the preparation, use, and/or formulation of adeno-associated virus capsid protein variants.
    Type: Application
    Filed: November 16, 2022
    Publication date: January 9, 2025
    Inventors: Mathieu Emmanuel Nonnenmacher, Matthew Alan Child, Jinzhao Hou, Jiangyu Li, Shaoyong Li, Tyler Christopher Moyer, Wei Wang, Matteo Placido Placidi, Robert H. Vass, Brett Hoffman, Elisabeth Knoll, Yanqun Shu, Nilesh Navalkishor Pande, Jeffrey Scott Thompson
  • Chimeric capsids
    Patent number: 12180500
    Abstract: The present invention relates to viral vectors and methods of their production and use.
    Type: Grant
    Filed: January 17, 2020
    Date of Patent: December 31, 2024
    Assignee: Voyager Therapeutics, Inc.
    Inventors: Robert Kotin, Jinzhao Hou, James McLaughlin
  • COMPOSITIONS AND METHODS FOR TREATING HUNTINGTON'S DISEASE
    Publication number: 20240415868
    Abstract: The present invention relates to small interfering RNA (siRNA) molecules against the HTT gene, adeno-associated viral (AAV) vectors encoding siRNA molecules and methods for treating Huntington's Disease (HD) using the siRNA molecules and AAV vectors.
    Type: Application
    Filed: February 29, 2024
    Publication date: December 19, 2024
    Inventors: Dinah Wen-Yee Sah, Jinzhao Hou, Pengcheng Zhou, Xin Wang, Jochen Deckert, Markus Hossbach
  • RECOMBINANT ADENO-ASSOCIATED VIRUS WITH MODIFIED AAV CAPSID POLYPEPTIDES
    Publication number: 20240398992
    Abstract: The present invention relates to a modified adeno-associated virus (AAV) capsid polypeptide and a novel recombinant adeno-associated virus (rAAV) comprising the modified AAV capsid polypeptide for delivering the gene product for the therapy. The present invention also relates to a pharmaceutical composition comprising the rAAV of the present invention, and a method of treating a retinal disease comprising the administration of the rAAV or the pharmaceutical composition of the present invention to an eye of a subject in need thereof.
    Type: Application
    Filed: August 16, 2024
    Publication date: December 5, 2024
    Applicant: Skyline Therapeutics Limited
    Inventors: Yanqun SHU, Jinzhao HOU, Heping LI, Qiongqiong REN, Lumei XIAO, Bing WU, Peilu LI
  • Rescue of central and peripheral neurological phenotype of friedreich's ataxia by intravenous delivery
    Patent number: 12146150
    Abstract: Described herein are compositions and methods for treating Friedreich's Ataxia (FA) using adeno-associated virus (AAV) to deliver therapeutics agents.
    Type: Grant
    Filed: September 13, 2022
    Date of Patent: November 19, 2024
    Assignees: VOYAGER THERAPEUTICS, INC., INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITÉ DE STRASBOURG
    Inventors: Dinah Wen-Yee Sah, Martin Goulet, Holger Patzke, Yanqun Shu, Jinzhao Hou, Hélène Puccio
  • Compositions and methods of treating amyotrophic lateral sclerosis (ALS)
    Patent number: 12123002
    Abstract: The present invention relates to small interfering RNA (siRNA) molecules against the SOD1 gene, adeno-associated viral (AAV) vectors encoding siRNA molecules and methods for treating amyotrophic lateral sclerosis (ALS) using the siRNA molecules and AAV vectors.
    Type: Grant
    Filed: December 20, 2022
    Date of Patent: October 22, 2024
    Assignee: Voyager Therapeutics, Inc.
    Inventors: Dinah Wen-Yee Sah, Jinzhao Hou, Mathieu E. Nonnenmacher, Pengcheng Zhou, Markus Hossbach, Jochen Deckert
  • Treatment of amyotrophic lateral sclerosis (ALS)
    Patent number: 12116589
    Abstract: The present invention relates to AAVs encoding a SOD1 targeting polynucleotide which may be used to treat amyotrophic lateral sclerosis (ALS) and/or canine degenerative myelopathy (DM).
    Type: Grant
    Filed: August 4, 2022
    Date of Patent: October 15, 2024
    Assignee: Voyager Therapeutics, Inc.
    Inventors: Dinah Wen-Yee Sah, Qingmin Chen, Joan R. Coates, Holger Patzke, Jinzhao Hou
  • Modulatory polynucleotides
    Patent number: 12084659
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of modulatory polynucleotides.
    Type: Grant
    Filed: November 4, 2021
    Date of Patent: September 10, 2024
    Assignee: VOYAGER THERAPEUTICS, INC.
    Inventors: Dinah Wen-Yee Sah, Jinzhao Hou, Mathieu Nonnenmacher
  • CENTRAL NERVOUS SYSTEM TARGETING POLYNUCLEOTIDES
    Publication number: 20240285667
    Abstract: The present disclosure relates to compositions, methods and processes for the formulation and for the administration of a gene therapy agent using parvovirus e.g., adeno-associated virus (AAV) to the CNS, CNS tissues, CNS structures or CNS cells.
    Type: Application
    Filed: November 22, 2023
    Publication date: August 29, 2024
    Inventors: Gregory Robert Stewart, Dinah Wen-Yee Sah, Jinzhao Hou, Adrian Philip Kells, Martin Goulet, Kartik Ramamoorthi, Pengcheng Zhou, Yanqun Shu
  • Modulatory polynucleotides
    Patent number: 12071625
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of modulatory polynucleotides.
    Type: Grant
    Filed: October 8, 2021
    Date of Patent: August 27, 2024
    Assignee: VOYAGER THERAPEUTICS, INC.
    Inventors: Jinzhao Hou, Mathieu E. Nonnenmacher, Pengcheng Zhou
  • AAV FOR THE GENE THERAPY OF WET-AMD
    Publication number: 20240252686
    Abstract: The present invention provides a polynucleotide and vector, in particular AAV vector, encoding a nanobody against VEGF. The present invention also provides a method of treating a disease associated with VEGF, such as the overexpression of VEGF, e.g., Wet-AMD and DME comprising administering the vector by, e.g., intravitreal injection to provide stable expression of the nanobody in eyes.
    Type: Application
    Filed: March 15, 2024
    Publication date: August 1, 2024
    Applicant: Skyline Therapeutics Limited
    Inventors: Jinzhao HOU, Yanqun SHU, Qiongqiong REN, Heping LI
  • COMPOSITIONS AND METHODS OF TREATING HUNTINGTON'S DISEASE
    Publication number: 20240226203
    Abstract: The present invention relates to adeno-associated viral (AAV) particles encoding siRNA molecules and methods for treating Huntington's Disease (HD).
    Type: Application
    Filed: July 13, 2023
    Publication date: July 11, 2024
    Inventors: Dinah Wen-Yee Sah, Fen Chen, Pengcheng Zhou, Xin Wang, Yanqun Shu, Jinzhao Hou, Jochen Deckert, Markus Hossbach
  • AAV CAPSIDS WITH INCREASED TROPISM TO BRAIN TISSUE
    Publication number: 20240200097
    Abstract: The disclosure relates to compositions, methods, and processes for the preparation, use, and/or formulation of adeno-associated virus capsid proteins, wherein the capsid proteins comprise targeting peptide inserts for enhanced tropism to a target tissue.
    Type: Application
    Filed: November 16, 2023
    Publication date: June 20, 2024
    Inventors: Mathieu E. Nonnenmacher, Jinzhao Hou, Wei Wang, Matthew Child, Shaoyong Li