Abstract: A pharmaceutical composition comprises a polyethylene glycol having a molecular weight in the range from about 1,000 to about 10,000, and a water-soluble cellulose derivative having a molecular weight in the range from about 50,000 to 120,000. The composition can further comprise boric acid and/or phosphate, a non-ionic surfactant, and/or an ophthalmic therapeutic agent. The composition is effective in treating, controlling, ameliorating, or reversing one or more conditions or symptoms of dry eye.

Abstract: A composition for promoting wound healing comprises a bioadhesive polymer and a pharmaceutically acceptable liquid medium. Such a composition is applied to a wound to promote healing of the wound. The bioadhesive polymer can be selected from the group consisting of natural or synthetic hydrophilic polymers and hydrogels.

Abstract: A composition for treating, controlling, reducing, or ameliorating inflammatory pain comprises a dissociated glucocorticoid receptor agonist (“DIGRA”), a prodrug thereof, a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable ester thereof. The composition can comprise an additional anti-inflammatory agent and can be formulated for topical application, injection, or implantation. It may be used in a method of managing ocular inflammation and/or pain such that it has lower risk of eliciting increased intraocular pressure seen with glucocorticoids.

Abstract: A composition for treating, controlling, reducing, or ameliorating inflammatory pain comprises a dissociated glucocorticoid receptor agonist (“DIGRA”), a prodrug thereof, a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable ester thereof. The composition can comprise an additional anti-inflammatory agent and can be formulated for topical application, injection, or implantation. It may be used in a method of managing post-surgical ocular pain such that it has lower risk of eliciting adverse side effects seen with other therapeutic agents.

Abstract: A composition for modulating generation of pro-inflammatory cytokines comprises levocabastine or a pharmaceutically acceptable salt or ester thereof. Such composition is useful for treating or controlling diseases having an inflammatory component, such as ocular diseases that are caused by inflammation or have inflammatory sequelae.

Abstract: Compositions for modulating endophthalmitis comprise a fluoroquinolone having one of Formulae I-VIII. Methods for modulating endophthalmitis comprise administering such compositions to a subject in need thereof. The compositions and methods are suitable for modulating post-operative endophthalmitis, post-traumatic endophthalmitis, non-infectious endophthalmitis, panophthalmitis, hematogenous endophthalmitis, or combinations thereof.

Abstract: A multipurpose lens care solution comprising 0.005 wt. % to 1 wt. % of an anionic biopolymer, and an antimicrobial agent selected from 0.5 ppm to 2 ppm of poly(hexamethylene biguanide), 0.5 ppm to 2 ppm polyquaternium-1, or 1 ppm to 4 ppm alexidine. The lens care solution exhibits a ZO-1 immunostaining of HCEpiC similar to phosphate buffered saline for after thirty minutes of contact time with the solution. The lens care solution will also have a transepithelial electrical resistance (TEER) of HCEpiC within a 25% difference or less than phosphate buffered saline in Ohm/cm2 after one hour of contact time with a 3:1 dilution (solution:DMEM), or the ECIS electrode arrays exhibit a 25% difference or less than phosphate buffered saline in Ohm after one hour of contact time with a 1:1 dilution (solution:DMEM).

Abstract: Compositions for modulating endophthalmitis comprise a fluoroquinolone having one of Formulae I-VIII. Methods for modulating endophthalmitis comprise administering such compositions to a subject in need thereof. The compositions and methods are suitable for modulating post-operative endophthalmitis, post-traumatic endophthalmitis, non-infectious endophthalmitis, panophthalmitis, hematogenous endophthalmitis, or combinations thereof.

Abstract: Compositions for modulating an inflammation comprise a fluoroquinolone having one of Formulae I-VIII. Methods for modulating an inflammation comprise administering such compositions to a subject in need thereof. The compositions and methods are suitable for modulating an ocular or ophthalmic inflammation, including uveitis, vernal keratoconjunctivitis, or inflammation associated with contact lens-associated corneal infiltrates.

Abstract: A composition for treating, reducing, ameliorating, alleviating, or preventing a dry eye condition or an opthalmologic disorder that has an etiology in inflammation comprises an inhibitor of activity of poly(ADP-ribose) polymerase (“PARP”). The composition can also include a modulator of pro-inflammatory gene expression.

Abstract: In accordance with the preferred embodiment of the present invention all remote units (113–118) participating in a group call can actively transmit uplink communications to their respective base stations (101–102) via low-data rate traffic channels (103–108). The remote units having the highest transmit energies are summed and broadcast to all remote units (113–118) participating in the group call. Because only those remote units having the highest transmit energies are summed and broadcast, network congestion is greatly reduced.

Abstract: During a group call, each remote unit (113–118) receives a downlink supplemental transmission (109–110) that contains high-speed data (e.g., video). A single supplemental channel is utilized for each base station (101–102). On the uplink side, the supplemental channel is shared among all remote units, however only one remote unit (113–118) is allowed to transmit at a time utilizing the uplink supplemental channel. A decision is made as to which remote unit is providing a highest-voice-energy fundamental channel uplink, and that remote unit is assigned the uplink supplemental channel. The remote unit, that is currently transmitting utilizing the uplink supplemental channel, has its transmission broadcast (via downlink supplemental channels (109–110)) to all other remote units participating in the multicast.

Abstract: In a wireless code-division multiple access (CDMA) system (100), a talkgroup (101) of subscriber units is provided. A sub-talkgroup (102) of subscriber units, forming a part of the talkgroup is assigned at least one inbound channel (416-417). The talkgroup is assigned outbound channels (415). Members of the sub-talkgroup may simultaneously transmit voice information (410-411) using the at least one inbound channel, which voice information is summed (412) and re-transmitted to the talkgroup using the outbound channels. Voice information is summed so that an individual talker receives summed voice information without the individual subscriber's voice content. Subscriber units in the sub-listengroup are allowed to transmit voice information only after requesting, and receiving, an additional inbound channel.

Abstract: The present invention provides a method and apparatus that enables handover of a mobile station between a cellular network and a wireless network without control intervention from the cellular network and independent of employed air interface technology. The signaling and control of a switch, for example SS7 messaging, is not required to achieve the handovers implemented by the present invention. In particular, a call is connected (504) between a mobile station (202) and a remote station (204) through a media gateway (210). The media gateway is connected to the mobile station via a first connection line and to the remote station via a second connection line. Next, a communication directed to a predetermined number by the mobile station is received (520) or, in the alternative, a connection signal that includes a call header is sent to the mobile station. A third connection line between the media gateway and the mobile station is then established (524).

Abstract: The present invention provides a method and apparatus that enables handover of a mobile station between a cellular network and a wireless network without control intervention from the cellular network and independent of employed air interface technology. The signaling and control of a switch, for example SS7 messaging, is not required to achieve the handovers implemented by the present invention. In particular, the present invention is a wireless communication device (202) comprising a first transceiver circuit (604), a second transceiver circuit (606) and a main circuit (608, 610, 612, 614) coupled to the first and second transceiver circuits. The first transceiver circuit communicates with a first network within a first area of coverage, and the second transceiver circuit communicates with a second network within a second area of coverage.

Abstract: The present invention provides a method and apparatus that enables handover of a mobile station between a cellular network and a wireless network without control intervention from the cellular network and independent of employed air interface technology. The signaling and control of a switch, for example SS7 messaging, is not required to achieve the handovers implemented by the present invention. In particular, a call is connected (504) between a mobile station (202) and a remote station (204) through a media gateway (210). The media gateway is connected to the mobile station via a first connection line and to the remote station via a second connection line. Next, a communication directed to a predetermined number by the mobile station is received (520) or, in the alternative, a connection signal that includes a call header is sent to the mobile station. A third connection line between the media gateway and the mobile station is then established (524).

Abstract: The present invention provides a method and apparatus that enables handover of a mobile station between a cellular network and a wireless network without control intervention from the cellular network and independent of employed air interface technology. The signaling and control of a switch, for example SS7 messaging, is not required to achieve the handovers implemented by the present invention. In particular, a call is connected (508) between a mobile station (202) and a remote station (204) through a media gateway (210). The media gateway is connected to the mobile station via a first connection line and to the remote station via a second connection line. When the mobile station has entered (514, 516) a transition area (302), a third connection line is established (518) between the media gateway and the mobile station.

Abstract: The present invention provides a method and apparatus that enables handover of a mobile station between a cellular network and a wireless network without control intervention from the cellular network and independent of employed air interface technology. The signaling and control of a switch, for example SS7 messaging, is not required to achieve the handovers implemented by the present invention. In particular, a call is connected (508) between a mobile station (202) and a remote station (204) through a media gateway (210). The media gateway is connected to the mobile station via a first connection line and to the remote station via a second connection line. When the mobile station has entered (514, 516) a transition area (302), a third connection line is established (518) between the media gateway and the mobile station.