Patents by Inventor Jiping Fu

Jiping Fu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TETRAHYDRO-1H-CYCLOPENTA[CD]INDENE DERIVATIVES AS HYPOXIA INDUCIBLE FACTOR-2(ALPHA) INHIBITORS
    Publication number: 20230373909
    Abstract: The present disclosure provides certain tetrahydro-1H-cyclopenta[cd]indene compounds that are Hypoxia Inducible Factor 2? (HIF-2?) inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of HIF-2?. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.
    Type: Application
    Filed: July 12, 2023
    Publication date: November 23, 2023
    Inventors: Jiping FU, Yan Lou, Yigang He
  • Tetrahydro-1H-cyclopenta[cd]indene derivatives as hypoxia inducible factor-2(alpha) inhibitors
    Patent number: 11753366
    Abstract: The present disclosure provides certain tetrahydro-1H-cyclopenta[cd]indene compounds that are Hypoxia Inducible Factor 2? (HIF-2?) inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of HIF-2?. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.
    Type: Grant
    Filed: February 11, 2022
    Date of Patent: September 12, 2023
    Assignee: NIKANG THERAPEUTICS, INC.
    Inventors: Jiping Fu, Yan Lou, Yigang He
  • PROCESS OF PREPARING 3-FLUORO-5(((1R,2AR)-3,3,4,4-TETRAFLUORO-1,2A-DIHYDROXY-2,2A,3,4-TETRAHYDRO-1H-CYCLOPENTA[CD]INDEN-7-YL)-OXY)BENZONITRILE
    Publication number: 20230202970
    Abstract: Disclosed herein are processes for preparing certain intermediates useful in the synthesis of 3-fluoro-5-(((1S,2aR)-1,3,3,4,4-pentafluoro-2a-hydroxy-2,2a,3,4-tetrahydro-1H-cyclopenta[cd]inden-7-yl)oxy)benzonitrile or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: March 2, 2023
    Publication date: June 29, 2023
    Inventors: Jiping FU, Yan LOU, Yigang HE, Yuetao SHI, Peng ZHOU, Xingxing LI
  • FUSED TRICYCLIC RING DERIVATIVES AS SRC HOMOLOGY-2 PHOSPHATE INHIBITORS
    Publication number: 20230167134
    Abstract: The present disclosure provides certain fused tricyclic ring derivatives that are Src Homology-2 phosphatase (SHP2) inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of SHP2. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.
    Type: Application
    Filed: November 1, 2022
    Publication date: June 1, 2023
    Inventors: Jiping FU, Yan LOU, Yigang HE
  • Process of preparing 3-fluoro-5(((1R,2aR)-3,3,4,4-tetrafluoro-1,2a-dihydroxy-2,2a,3,4-tetrahydro-1H-cyclopenta[cd]inden-7-yl)-oxy)benzonitrile
    Patent number: 11634382
    Abstract: Disclosed herein are processes for preparing certain intermediates useful in the synthesis of 3-fluoro-5-(((1S,2aR)-1,3,3,4,4-pentafluoro-2a-hydroxy-2,2a,3,4-tetrahydro-1H-cyclopenta[cd]inden-7-yl)oxy)benzonitrile or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: October 15, 2021
    Date of Patent: April 25, 2023
    Assignee: NiKang Therapeutics, Inc.
    Inventors: Jiping Fu, Yan Lou, Yigang He, Yuetao Shi, Peng Zhou, Xingxing Li
  • PROCESSES OF MAKING 3-FLUORO-5-(((1S,2aR)-1,3,3,4,4-PENTAFLUORO-2a-HYDROXY-2,2a,3,4-TETRAHYDRO-1H-CYCLOPENTA[CD]INDEN-7-YL)OXY)-BENZONITRILE AND POLYMORPHS THEREOF
    Publication number: 20230115881
    Abstract: The present disclosure provides certain processes of making 3-fluoro-5-(((1S,2aR)-1,3,3,4,4-pentafluoro-2a-hydroxy-2,2a,3,4-tetrahydro-1H-cyclopenta[cd]inden-7-yl)oxy)-benzonitrile (Compound 1) and certain polymorphs thereof. Also provided are pharmaceutical compositions comprising a crystalline polymorph form of Compound 1 and processes for preparing such polymorph forms.
    Type: Application
    Filed: October 11, 2022
    Publication date: April 13, 2023
    Inventors: Charles M. COOK, Jiping FU, Yigang HE, Yan LOU, Rongzhen CHEN, Yan DONG
  • Fused tricyclic ring derivatives as Src homology-2 phosphate inhibitors
    Patent number: 11518772
    Abstract: The present disclosure provides certain fused tricyclic ring derivatives that are Src Homology-2 phosphatase (SHP2) inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of SHP2. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.
    Type: Grant
    Filed: September 18, 2020
    Date of Patent: December 6, 2022
    Assignee: NIKANG THERAPEUTICS, INC.
    Inventors: Jiping Fu, Yan Lou, Yigang He
  • HYPOXIA INDUCIBLE FACTOR-2(ALPHA) INHIBITORS AND THEIR USE IN THE TREATMENT OF DISEASES
    Publication number: 20220380302
    Abstract: The present disclosure is directed certain Hypoxia Inducible Factor 2? (HIF-2?) inhibitors and their use in the treatment of diseases mediated by HIF-2? such as cancer. Also provided is the use of HIF-2? inhibitors in combination with a poly (ADP-ribose) polymerase (PARP) inhibitor. In particular, the present disclosure is directed to methods for the treatment of cancers using a HIF-2? inhibitor in combination with a PARP inhibitor and pharmaceutical compositions comprising the same.
    Type: Application
    Filed: July 19, 2022
    Publication date: December 1, 2022
    Inventors: Jiping FU, Yan LOU, Yigang HE, Jing LU
  • Tri-substituted heteroaryl derivatives as Src homology-2 phosphatase inhibitors
    Patent number: 11459340
    Abstract: The present disclosure provides certain tri-substituted heteroaryl derivatives that are Src Homology-2 phosphatase (SHP2) inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of SHP2. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.
    Type: Grant
    Filed: September 17, 2019
    Date of Patent: October 4, 2022
    Assignee: NIKANG THERAPEUTICS, INC.
    Inventors: Jiping Fu, Yan Lou, Yigang He
  • TRICYCLIC DERIVATIVES AS HYPOXIA INDUCIBLE FACTOR-2(ALPHA) INHIBITORS
    Publication number: 20220274914
    Abstract: The present disclosure provides certain tricyclic compounds that are Hypoxia Inducible Factor 2? (HIF-2?) inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of HIF-2?. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.
    Type: Application
    Filed: July 21, 2020
    Publication date: September 1, 2022
    Inventors: Jiping FU, Yan LOU, Yigang HE
  • Hypoxia inducible factor-2(alpha) inhibitors and their use in the treatment of diseases
    Patent number: 11420936
    Abstract: The present disclosure is directed certain Hypoxia Inducible Factor 2? (HIF-2?) inhibitors and their use in the treatment of diseases mediated by HIF-2? such as cancer. Also provided is the use of HIF-2? inhibitors in combination with a poly (ADP-ribose) polymerase (PARP) inhibitor. In particular, the present disclosure is directed to methods for the treatment of cancers using a HIF-2? inhibitor in combination with a PARP inhibitor and pharmaceutical compositions comprising the same.
    Type: Grant
    Filed: March 3, 2022
    Date of Patent: August 23, 2022
    Assignee: NIKANG THERAPEUTICS, INC.
    Inventors: Jiping Fu, Yan Lou, Yigang He
  • HYPOXIA INDUCIBLE FACTOR-2(ALPHA) INHIBITORS AND THEIR USE IN THE TREATMENT OF DISEASES
    Publication number: 20220185771
    Abstract: The present disclosure is directed certain Hypoxia Inducible Factor 2? (HIF-2?) inhibitors and their use in the treatment of diseases mediated by HIF-2? such as cancer. Also provided is the use of HIF-2? inhibitors in combination with a poly (ADP-ribose) polymerase (PARP) inhibitor. In particular, the present disclosure is directed to methods for the treatment of cancers using a HIF-2? inhibitor in combination with a PARP inhibitor and pharmaceutical compositions comprising the same.
    Type: Application
    Filed: March 3, 2022
    Publication date: June 16, 2022
    Inventors: Jiping FU, Yan LOU, Yigang HE
  • FUSED POLYCYCLIC PYRIDONE COMPOUNDS AS INFLUENZA VIRUS REPLICATION INHIBITORS
    Publication number: 20220177487
    Abstract: Provided are compounds of Formula (IA) that inhibit orthomyxovirus replication such as Influenza viruses and are accordingly useful for treatment of viral infections caused by orthomyxoviruses. Also provided are pharmaceutical compositions containing these compounds and methods of using these compounds to treat or prevent viral infections caused by orthomyxovirus such as Influenza viruses.
    Type: Application
    Filed: March 31, 2020
    Publication date: June 9, 2022
    Inventors: Jiping FU, Yigang HE, Yan LOU
  • TETRAHYDRO-1H-CYCLOPENTA[CD]INDENE DERIVATIVES AS HYPOXIA INDUCIBLE FACTOR-2(ALPHA) INHIBITORS
    Publication number: 20220162158
    Abstract: The present disclosure provides certain tetrahydro-1H-cyclopenta[cd]indene compounds that are Hypoxia Inducible Factor 2? (HIF-2?) inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of HIF-2?. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.
    Type: Application
    Filed: February 11, 2022
    Publication date: May 26, 2022
    Inventors: Jiping FU, Yan LOU, Yigang HE
  • PROCESS OF PREPARING 3-FLUORO-5(((1R,2AR)-3,3,4,4-TETRAFLUORO-1,2A-DIHYDROXY-2,2A,3,4-TETRAHYDRO-1H-CYCLOPENTA[CD]INDEN-7-YL)-OXY)BENZONITRILE
    Publication number: 20220119345
    Abstract: Disclosed herein are processes for preparing certain intermediates useful in the synthesis of 3-fluoro-5-(((1S,2aR)-1,3,3,4,4-pentafluoro-2a-hydroxy-2,2a,3,4-tetrahydro-1H-cyclopenta[cd]inden-7-yl)oxy)benzonitrile or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: October 15, 2021
    Publication date: April 21, 2022
    Inventors: Jiping FU, Yan LOU, Yigang HE, Yuetao SHI, Peng ZHOU, Xingxing LI
  • FUSED TRICYCLIC PYRAZOLO-DIHYDROPYRAZINYL-PYRIDONE COMPOUNDS AS ANTIVIRALS
    Publication number: 20220105091
    Abstract: The invention provides compounds of Formula (I) as described herein, along with pharmaceutically acceptable salts, pharmaceutical compositions and pharmaceutical combinations containing such compounds, as well as methods to use these compounds, salts and compositions for treating viral infections, particularly infections caused by hepatitis B virus (HBV), and for reducing the occurrence of serious conditions associated with HBV.
    Type: Application
    Filed: December 14, 2021
    Publication date: April 7, 2022
    Inventors: Jiping Fu, Wooseok Han, Xianming Jin, Keith Bruce Pfister, Joseph Michael Young
  • Tetrahydro-1H-cyclopenta[cd]indene derivatives as hypoxia inducible factor-2? inhibitors
    Patent number: 11267782
    Abstract: The present disclosure provides certain tetrahydro-1H-cyclopenta[cd]indene compounds that are Hypoxia Inducible Factor 2? (HIF-2?) inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of HIF-2?. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.
    Type: Grant
    Filed: March 30, 2021
    Date of Patent: March 8, 2022
    Assignee: NIKANG THERAPEUTICS, INC.
    Inventors: Jiping Fu, Yan Lou, Yigang He
  • 2,3-DIHYDROBENZO[b]THIOPHENE DERIVATIVES AS HYPOXIA INDUCIBLE FACTOR-2(ALPHA) INHIBITORS
    Publication number: 20220054451
    Abstract: The present disclosure provides certain 2,3-dihydrobenzo[b]thiophene compounds that are Hypoxia Inducible Factor 2? (HIF-2?) inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of HIF-2?. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.
    Type: Application
    Filed: September 10, 2019
    Publication date: February 24, 2022
    Inventors: Jiping FU, Yan LOU, Yigang HE
  • Fused tricyclic pyrazolo-dihydropyrazinyl-pyridone compounds as antivirals
    Patent number: 11234977
    Abstract: The invention provides compounds of Formula (I) as described herein, along with pharmaceutically acceptable salts, pharmaceutical compositions and pharmaceutical combinations containing such compounds, as well as methods to use these compounds, salts and compositions for treating viral infections, particularly infections caused by hepatitis B virus (HBV), and for reducing the occurrence of serious conditions associated with HBV.
    Type: Grant
    Filed: December 19, 2018
    Date of Patent: February 1, 2022
    Assignee: Novartis AG
    Inventors: Jiping Fu, Wooseok Han, Xianming Jin, Keith Bruce Pfister, Joseph Michael Young
  • INDANE DERIVATIVES AS HYPOXIA INDUCIBLE FACTOR-2(ALPHA) INHIBITORS
    Publication number: 20210380536
    Abstract: The present disclosure provides certain indane compounds that are Hypoxia Inducible Factor 2? (HIF-2?) inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of HIF-2?. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.
    Type: Application
    Filed: October 16, 2019
    Publication date: December 9, 2021
    Inventors: Jiping FU, Yan LOU, Yigang HE