Patents by Inventor Jiqing Jiang
Jiqing Jiang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230365580Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds; and methods of using such compounds for treating joint damage or injury in a mammal, for inducing hyaline cartilage production or for inducing differentiation of chondrogenic progenitor cells into mature chondrocytes.Type: ApplicationFiled: July 18, 2023Publication date: November 16, 2023Inventors: Ha-Soon CHOI, Jiqing JIANG, James Paul LAJINESS, Bao NGUYEN, Hank Michael James PETRASSI
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Patent number: 11796425Abstract: Disclosed is a pullout force measurement test device based on an anchor group effect of a marine pipeline, and a measurement method. The test device includes a support frame, a winch, a lifting plate, an upper hanging rope, a force measuring mechanism mounted on the upper hanging rope, two anchor plate mechanisms, and two lower hanging ropes, where each pair of the lower hanging ropes and the anchor plate mechanisms are located on both sides of the upper hanging rope; each anchor plate mechanism includes a model box, a soil sample filled in the model box, an anchor plate embedded in the soil sample, and a pulley assembly used for adjusting a pullout angle of the anchor plate; one end of each lower hanging rope is connected to the lifting plate, and the other end thereof is connected to the anchor plate of the corresponding anchor plate mechanism.Type: GrantFiled: May 9, 2023Date of Patent: October 24, 2023Assignee: Zhejiang University City CollegeInventors: Chengbao Hu, Bing Li, Gang Wei, Jiqing Jiang, Xi Wu, Zhi Ding, Bin Chen, Jianying Yu, Shuming Su
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Patent number: 11753416Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds; and methods of using such compounds for treating joint damage or injury in a mammal, for inducing hyaline cartilage production or for inducing differentiation of chondrogenic progenitor cells into mature chondrocytes.Type: GrantFiled: July 6, 2021Date of Patent: September 12, 2023Assignee: Novartis AGInventors: Ha-Soon Choi, Jiqing Jiang, James Paul Lajiness, Bao Nguyen, Hank Michael James Petrassi
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Patent number: 11658638Abstract: A resonator comprising a magnetoelastic body having a mass load portion and an active resonating portion can be used in implementations such as a security tag. The resonator includes a mass at the mass load portion of the magnetoelastic body. Displacement of the magnetoelastic body is configured to occur at both the mass load portion and the active resonating portion. A strain at the active resonating portion during displacement is configured to be greater than a strain at the mass load portion during displacement.Type: GrantFiled: August 28, 2020Date of Patent: May 23, 2023Assignee: The Regents of the University of MichiganInventors: Scott R. Green, Yogesh Gianchandani, Ramprasad M. Nambisan, Jiqing Jiang
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Patent number: 11543465Abstract: Encapsulation packages for stent-deployable monitoring devices formed of resonator sensors and allowing for magnetic biasing elements that exhibit a targeted impact on the mechanical characteristics of a stent are provided. Encapsulation packages are formed of different types and include a longitudinal shield and curved end on profile for aligning the shield within the deployable stent, the shield having perforations such that a resonator can be positioned adjacent the perforations for allowing particulate within the stent to collect and be measured by the resonator during deployment.Type: GrantFiled: April 6, 2020Date of Patent: January 3, 2023Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Scott Green, Yogesh B. Gianchandani, Richard Kwon, Grace Elta, Jiqing Jiang, Ramprasad Nambisan
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Publication number: 20210347784Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds; and methods of using such compounds for treating joint damage or injury in a mammal, for inducing hyaline cartilage production or for inducing differentiation of chondrogenic progenitor cells into mature chondrocytes.Type: ApplicationFiled: July 6, 2021Publication date: November 11, 2021Inventors: Ha-Soon CHOI, Jiqing JIANG, James Paul LAJINESS, Bao NGUYEN, Hank Michael James Petrassi
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Patent number: 11091499Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; (I) or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds; and methods of using such compounds for treating joint damage or injury in a mammal, for inducing hyaline cartilage production or for inducing differentiation of chondrogenic progenitor cells into mature chondrocytes.Type: GrantFiled: June 7, 2018Date of Patent: August 17, 2021Assignee: Novartis AGInventors: Ha-Soon Choi, Jiqing Jiang, James Paul Lajiness, Bao Nguyen, Hank Michael James Petrassi
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Publication number: 20210139361Abstract: A device and method for mud solidification based on electro-osmosis well points cooperating with well-points dewatering. The method includes the following steps: 1) preparation; 2) construction of well point pipe positioning frame beams; 3) assembly of a mobile trestle platform; 4) well point pipe arrangement; 5) well point/electro-osmosis dewatering; 6) filtrate treatment; 7) well point pipe dismantling; and 8) excavation and transportation of solidified drilling slag for utilization. According to the disclosure, well point pipes are adopted and used as an anode and a cathode of an electro-osmosis well, and on-site quick solidification of pile foundation mud is implemented through the electro-osmosis combined with light well-points dewatering; by the adoption of the well point pipe positioning frame beams, the problems that drilling slag in a sedimentation tank has a large water content and it is difficult to arrange and fix the well point pipes are well solved.Type: ApplicationFiled: November 12, 2020Publication date: May 13, 2021Applicants: Shaoxing University, Zhejiang University City CollegeInventors: Yunjin HU, Feng CHEN, Jiqing JIANG, Lianying ZHOU, Lu SHI
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Publication number: 20210079010Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; (I) or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds; and methods of using such compounds for treating joint damage or injury in a mammal, for inducing hyaline cartilage production or for inducing differentiation of chondrogenic progenitor cells into mature chondrocytes.Type: ApplicationFiled: June 7, 2018Publication date: March 18, 2021Inventors: Ha-Soon CHOI, Jiqing JIANG, James Paul LAJINESS, Bao NGUYEN, Hank Michael James Petrassi
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Publication number: 20210067137Abstract: A resonator comprising a magnetoelastic body having a mass load portion and an active resonating portion can be used in implementations such as a security tag. The resonator includes a mass at the mass load portion of the magnetoelastic body. Displacement of the magnetoelastic body is configured to occur at both the mass load portion and the active resonating portion. A strain at the active resonating portion during displacement is configured to be greater than a strain at the mass load portion during displacement.Type: ApplicationFiled: August 28, 2020Publication date: March 4, 2021Inventors: Scott R. GREEN, Yogesh Gianchandani, Ramprasad M. Nambisan, Jiqing Jiang
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Publication number: 20200319268Abstract: Encapsulation packages for stent-deployable monitoring devices formed of resonator sensors and allowing for magnetic biasing elements that exhibit a targeted impact on the mechanical characteristics of a stent are provided. Encapsulation packages are formed of different types and include a longitudinal shield and curved end on profile for aligning the shield within the deployable stent, the shield having perforations such that a resonator can be positioned adjacent the perforations for allowing particulate within the stent to collect and be measured by the resonator during deployment.Type: ApplicationFiled: April 6, 2020Publication date: October 8, 2020Inventors: Scott Green, Yogesh B. Gianchandani, Richard Kwon, Grace Elta, Jiqing Jiang, Ramprasad Nambisan
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Patent number: 9216964Abstract: The invention provides a method, compounds and compositions for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula (I).Type: GrantFiled: July 9, 2013Date of Patent: December 22, 2015Assignee: Novartis AGInventors: Dai Cheng, Dong Han, Guobao Zhang, Yongqin Wan, Yun Feng Xie, Jiqing Jiang, Wenqi Gao, Shifeng Pan
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Publication number: 20130296333Abstract: The invention provides a method, compounds and compositions for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula (I).Type: ApplicationFiled: July 9, 2013Publication date: November 7, 2013Inventors: Dai Cheng, Dong Han, Guobao Zhang, Yongqin Wan, Yun Feng Xie, Jiqing Jiang, Wenqi Gao, Shifeng Pan
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Patent number: 8507491Abstract: The invention provides a method, compounds and compositions for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or GIi gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula (I).Type: GrantFiled: August 24, 2009Date of Patent: August 13, 2013Assignee: IRM LLCInventors: Dai Cheng, Dong Han, Guobao Zhang, Yongqin Wan, Yun Feng Xie, Jiqing Jiang, Wenqi Gao, Shifeng Pan
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Publication number: 20120202782Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or dysregulated B cell activities, particularly diseases or disorders that involve aberrant activation of inositol 1,4,5-trisphosphate 3-kinase B (ITPKb).Type: ApplicationFiled: April 12, 2012Publication date: August 9, 2012Applicant: IRM LLCInventors: Badry Bursulaya, Dai Cheng, Jiqing Jiang, Donald S. Karanewsky, Yi Liu, Shifeng Pan, Yongqin Wan, Xia Wang, Yun Feng Xie, Yang Yang
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Publication number: 20120196849Abstract: The invention provides a method for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula I.Type: ApplicationFiled: April 10, 2012Publication date: August 2, 2012Applicant: IRM LLCInventors: Wenqi Gao, Jiqing Jiang, Yongqin Wan, Dai Cheng, Dong Han, Xu Wu, Shifeng Pan
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Patent number: 8178526Abstract: The invention provides a novel class of compounds of formula (I), pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or dysregulated B cell activities, particularly diseases or disorders that involve aberrant activation of inositol 1,4,5-trisphosphate 3-kinase B (ITPKb).Type: GrantFiled: June 12, 2008Date of Patent: May 15, 2012Assignee: IRM LLCInventors: Badry Bursulaya, Dai Cheng, Jiqing Jiang, Donald S. Karanewsky, Yi Liu, Shifeng Pan, Yongqin Wan, Xia Wang, Yun Feng Xie, Yang Yang
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Patent number: 8178563Abstract: The invention provides a method for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula I.Type: GrantFiled: May 4, 2007Date of Patent: May 15, 2012Assignee: IRM LLCInventors: Wenqi Gao, Jiqing Jiang, Yongqin Wan, Dai Cheng, Dong Han, Xu Wu, Shifeng Pan
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Publication number: 20110263610Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated B cell activities, particularly diseases or disorders that involve aberrant activation of inositol 1,4,5-trisphosphate 3-kinase B (ITPKb).Type: ApplicationFiled: March 30, 2009Publication date: October 27, 2011Applicant: IRM LLCInventors: Yongqin Wan, Shifeng Pan, Guobao Zhang, Xia Wang, Yun Feng Xie, Jiqing Jiang, Dean Phillips, Yang Yang
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Publication number: 20110152282Abstract: The invention provides a method, compounds and compositions for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or GIi gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula (I).Type: ApplicationFiled: August 24, 2009Publication date: June 23, 2011Applicant: IRM LLCInventors: Dai Cheng, Dong Han, Guobao Zhang, Yongqin Wan, Yun Feng Xie, Jiqing Jiang, Wenqi Gao, Shifeng Pan