Abstract: A particulate form of dithiocarbamate-metal complex and at least one blood protein. The particulate form is obtained by a process having a sequential or simultaneous addition of individual components, resulting in their self-assembling. The aqueous dispersion of the particulate form is suitable for parenteral, oral and topical administration and for therapy and visualization of cancer.

Abstract: A complex particle form of dithiocarbamate-metal compound and at least one ligand, that is a polymer or a detergent is disclosed. The complex particle form is obtained by a process having a sequential or simultaneous addition of individual components, resulting in their self-assembling. The dry form or aqueous dispersion of the complex particle form is suitable for medicinal per-oral, topical and parenteral administration and for therapy and imaging of cancer.

Abstract: A particulate form of dithiocarbamate-metal complex and at least one blood protein. The particulate form is obtained by a process having a sequential or simultaneous addition of individual components, resulting in their self-assembling. The aqueous dispersion of the particulate form is suitable for parenteral, oral and topical administration and for therapy and visualization of cancer.

Abstract: A method of an extraction of follicular cells which is based on a principle of a hair extraction from a skin of mammals by the help of an extraction device, when during the extraction remains preserved also the root part of the hair surrounded by follicular cells, where the essence of the invention is that at least one hair from a sampling point of the skin is sucked in by the help of vacuum which is led form a body of the extraction device into an interspace of a two-cone collet fixed partly to the body and partly to an arbor where is subsequently by the interspace closing between its inner cone and an outer cone by the help of a counter pressure of the arbor this hair grasped and after it extracted from the skin.

Abstract: A method of an extraction of follicular cells which is based on a principle of a hair extraction from a skin of mammals by the help of an extraction device, when during the extraction remains preserved also the root part of the hair surrounded by follicular cells, where the essence of the invention is that at least one hair from a sampling point of the skin is sucked in by the help of vacuum which is led form a body of the extraction device into an interspace of a two-cone collet fixed partly to the body and partly to an arbor where is subsequently by the interspace closing between its inner cone and an outer cone by the help of a counter pressure of the arbor this hair grasped and after it extracted from the skin.

Abstract: Cdc25A has a role in a further signalling pathway for DNA repair which operates in response to DNA damage, in which Chk1 or Chk2 are activated following DNA damage and phosphorylate Cdc25A at one or more serine residues, and more particularly at Ser123 and/or Ser262 and/or Ser292 and/or Ser504. The phosphorylated Cdc25A is then recognized by the F-box protein and is then degraded in a proteasome dependent manner, thereby allowing the cells to undergo cell cycle arrest and repair. Accordingly, by interfering with the phosphorylation and/or degradation of Cdc25A and/or using other strategies to maintain Cdc25A level, this pathway can be used to prevent cells from undergoing repair and thereby increasing the accumulation of DNA damage in the cells, e.g. increasing the fraction of tumor cells which can be killed by DNA damaging therapeutic agents, such as radiation or anti-tumor drugs, or which undergo apoptosis.