Patents by Inventor Jiri Bartl

Jiri Bartl has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESS FOR MAKING IBRUTINIB
    Publication number: 20240092785
    Abstract: The presented invention relates to a process for preparation of Ibrutinib, comprising: a. Reacting compound of Formula (2) with compound of Formula (3) in a presence of Lewis acid to provide compound of Formula (4); b. Contacting compound of Formula (4) with toluene; c. Isolate a solid form of compound of Formula (4); d. Transforming compound of Formula (4) into Ibrutinib.
    Type: Application
    Filed: January 20, 2022
    Publication date: March 21, 2024
    Inventors: Petr MITAS, Libor VYKLICKY, Jiri BARTL, Oldrich SMEKAL
  • Process for preparing ozanimod
    Patent number: 11390593
    Abstract: The presented invention relates to a process for preparation of compound of formula (1) or a salt thereof (i.e.) ozanimod: (1). The invention also relates to intermediates used in the process.
    Type: Grant
    Filed: December 5, 2019
    Date of Patent: July 19, 2022
    Assignee: Synthon B.V.
    Inventors: Marian Buchlovic, Lenka Chalupova, Libor Vyklicky, Jiri Bartl
  • IMPROVED PROCESS FOR PREPARING OZANIMOD
    Publication number: 20210363117
    Abstract: The presented invention relates to a process for preparation of compound of formula (1) or a salt thereof (i.e.) ozanimod: (1). The invention also relates to intermediates used in the process.
    Type: Application
    Filed: December 5, 2019
    Publication date: November 25, 2021
    Inventors: Marian BUCHLOVIC, Lenka CHALUPOVA, Libor VYKLICKY, Jiri BARTL
  • Process for making 1-hydroxyalkylidene-1,1-biphosphonic acids
    Patent number: 8026388
    Abstract: Synthesis of biphosphonate compounds can be advantageously carried out in a solvent/diluent comprising a compound of formula (3) wherein R is hydrogen or a C1-C6 alkyl group; each of R1 is a C1-C6 alkyl group or both R1 groups are linked to form a C1-C3 alkylene group; and R2 is hydrogen, a C1-C6 alkyl group, a C1-C6 alkoxy group, or is linked together with R to form a C3-C7 carbon ring.
    Type: Grant
    Filed: July 10, 2009
    Date of Patent: September 27, 2011
    Assignee: Synthon BV
    Inventor: Jiri Bartl
  • Synthesis of paliperidone
    Patent number: 7977480
    Abstract: A 9-hydroxy or 9-acyloxy group can be added to a pyridopyrimidinone ring structure by a process comprising acylating a compound of formula (5) under Vilsmeier-Haack or Friedel-Crafts conditions to form a compound (6); and transforming with a peroxo-compound to obtain the compound (1). R represents hydrogen or a C1-C20 acyl group. The process is useful in the synthesis of paliperidone and derivatives.
    Type: Grant
    Filed: December 10, 2008
    Date of Patent: July 12, 2011
    Assignee: Synthon BV
    Inventors: Jiri Bartl, Jozef Krajcovic, Petr Benovsky
  • Paliperidone ketone
    Patent number: 7932385
    Abstract: A compound of formula (7.2) or an acid addition salt thereof. The compound can be used as a reference standard for monitoring the presence thereof in a paliperidone sample, including monitoring the completion of a paliperidone reaction. Reduction in the amount of the compound in paliperidone can be achieved by crystallization in the presence of a hydride reductant.
    Type: Grant
    Filed: July 10, 2009
    Date of Patent: April 26, 2011
    Assignee: Synthon BV
    Inventors: Jozef Krajcovic, Jiri Bartl, Petr Benovsky
  • PALIPERIDONE KETONE
    Publication number: 20100069633
    Abstract: A compound of formula (7.2) or an acid addition salt thereof. The compound can be used as a reference standard for monitoring the presence thereof in a paliperidone sample, including monitoring the completion of a paliperidone reaction. Reduction in the amount of the compound in paliperidone can be achieved by crystallization in the presence of a hydride reductant.
    Type: Application
    Filed: July 10, 2009
    Publication date: March 18, 2010
    Inventors: Jozef Krajcovic, Jiri Bartl, Petr Benovsky
  • SYNTHESIS OF PALIPERIDONE
    Publication number: 20100010218
    Abstract: A compound of formula (6) or an acid addition salt thereof in which G is (i) a leaving group A selected from a halo group and a sulfonyloxy group, or (ii) a group of the formula (20) is useful in processes of making paliperidone and related compounds.
    Type: Application
    Filed: July 10, 2009
    Publication date: January 14, 2010
    Inventors: Jiri Bartl, Petr Benovsky
  • PROCESS FOR MAKING 1-HYDROXYALKYLIDENE-1,1-BIPHOSPHONIC ACIDS
    Publication number: 20100010258
    Abstract: Synthesis of biphosphonate compounds can be advantageously carried out in a solvent/diluent comprising a compound of formula (3) wherein R is hydrogen or a C1-C6 alkyl group; each of R1 is a C1-C6 alkyl group or both R1 groups are linked to form a C1-C3 alkylene group; and R2 is hydrogen, a C1-C6 alkyl group, a C1-C6 alkoxy group, or is linked together with R to form a C3-C7 carbon ring.
    Type: Application
    Filed: July 10, 2009
    Publication date: January 14, 2010
    Inventor: Jiri BARTL
  • SYNTHESIS OF PALIPERIDONE
    Publication number: 20090156810
    Abstract: A 9-hydroxy or 9-acyloxy group can be added to a pyridopyrimidinone ring structure by a process comprising acylating a compound of formula (5) under Vilsmeier-Haack or Friedel-Crafts conditions to form a compound (6); and transforming with a peroxo-compound to obtain the compound (1). R represents hydrogen or a C1-C20 acyl group. The process is useful in the synthesis of paliperidone and derivatives.
    Type: Application
    Filed: December 10, 2008
    Publication date: June 18, 2009
    Inventors: Jiri Bartl, Jozef Krajcovic, Petr Benovsky
  • PALIPERIDONE DERIVATIVES
    Publication number: 20090036470
    Abstract: A compound of formula (1) is useful as a pharmaceutical and as an intermediate in making paliperidone. wherein Y is an acid-sensitive group of the formula: in which X represents an oxygen atom, a sulfur atom, or an —NH— group; Z represents a C2-C7 alkylene bridge; and R represents hydrogen or a C1-C4 alkyl group.
    Type: Application
    Filed: July 25, 2008
    Publication date: February 5, 2009
    Inventors: Jiri Bartl, Frantisek Picha
  • Montelukast amantadine salt
    Patent number: 7446116
    Abstract: An amantadine salt of montelukast is useful in purification of montelukast or its salts and as a pharmaceutical active ingredient.
    Type: Grant
    Filed: March 16, 2007
    Date of Patent: November 4, 2008
    Assignee: Synthon BV
    Inventors: Jiri Bartl, Frantisek Picha
  • PROCESS FOR MAKING RISPERIDONE AND INTERMEDIATES THEREFOR
    Publication number: 20080262227
    Abstract: The formation of risperidone is enhanced by the use of enriched Z-isomer oxime intermediate(s) of formula (3) or (7). The oxime(s) can be isomerically enriched by a variety of techniques including the use of the novel acetic acid salt thereof, which affords, inter alia, resolution of the isomers and/or by heat conversion.
    Type: Application
    Filed: June 18, 2008
    Publication date: October 23, 2008
    Inventors: Pavel Slanina, Jiri Bartl
  • Process for making risperidone and intermediates therefor
    Patent number: 7405298
    Abstract: The formation of risperidone is enhanced by the use of enriched Z-isomer oxime intermediate(s) of formula (3) or (7). The oxime(s) can be isomerically enriched by a variety of techniques including the use of the novel acetic acid salt thereof, which affords, inter alia, resolution of the isomers and/or by heat conversion.
    Type: Grant
    Filed: November 13, 2003
    Date of Patent: July 29, 2008
    Assignee: Synthon IP Inc.
    Inventors: Pavel Slanina, Jiri Bartl
  • PROCESS FOR MAKING AMLODIPINE, DERIVATIVES THEREOF, AND PRECURSORS THEREFOR
    Publication number: 20080070789
    Abstract: Impurities associated with the commercial production of amlodipine are identified along with methods of assaying the same.
    Type: Application
    Filed: November 19, 2007
    Publication date: March 20, 2008
    Inventors: Pavel Slanina, Jiri Bartl
  • MONTELUKAST AMANTADINE SALT
    Publication number: 20070225326
    Abstract: An amantadine salt of montelukast is useful in purification of montelukast or its salts and as a pharmaceutical active ingredient.
    Type: Application
    Filed: March 16, 2007
    Publication date: September 27, 2007
    Inventors: Jiri Bartl, Frantisek Picha
  • Process for making amlodipine, derivatives thereof, and precursors therefor
    Publication number: 20060167265
    Abstract: Purification of the phthalimidoamlodipine intermediate, especially by recrystallization, can provide an easier route to obtaining pharmaceutically pure amlodipine or its salts.
    Type: Application
    Filed: March 21, 2006
    Publication date: July 27, 2006
    Inventors: Theodorus Peters, Franciscus Benneker, Pavel Slanina, Jiri Bartl
  • Process for making amlodipine, derivatives thereof, and precursors therefor
    Publication number: 20050137405
    Abstract: Amlodipine and related analogues thereof are prepared by the following general reaction scheme: R1 and R2 each independently represent a C1-C4 alkyl group. The process provides for the formation of compounds of formula (1) in good yield and purity. Further, the compounds of formula (1) can be used as calcium channel blockers or as reference standards or reference markers for checking the purity of amlodipine.
    Type: Application
    Filed: February 19, 2005
    Publication date: June 23, 2005
    Inventors: Theodorus Peters, Franciscus Benneker, Pavel Slanina, Jiri Bartl
  • Process for making amlodipine, derivatives thereof, and precursors therefor
    Patent number: 6858738
    Abstract: Amlodipine and related analogues thereof are prepared by the following general reaction scheme: R1 and R2 each independently represent a C1-C4 alkyl group. The process provides for the formation of compounds of formula (1) in good yield and purity. Further, the compounds of formula (1) can be used as calcium channel blockers or as reference standards or reference markers for checking the purity of amlodipine.
    Type: Grant
    Filed: May 8, 2003
    Date of Patent: February 22, 2005
    Assignee: Synthon BV
    Inventors: Theodorus H. A. Peters, Franciscus B. G. Benneker, Pavel Slanina, Jiri Bartl
  • Risperidone monohydrochloride
    Publication number: 20040266790
    Abstract: Monohydrochloride salts of risperidone have been found to have useful properties. A preferred form is crystalline risperidone monohydrochloride hemipentahydrate. The monohydrochloride salts can be used in pharmaceutical compositions and methods such as for use in treating psychotic disorders.
    Type: Application
    Filed: April 16, 2004
    Publication date: December 30, 2004
    Inventors: Jiri Bartl, Reinerus G. Gieling