Patents by Inventor Jiri Damborsky
Jiri Damborsky has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11746135Abstract: The invention provides an isolated thermostable polypeptide possessing FGF2 activity and having at least 85% sequence identity to SEQ ID NO: 2 (FGF2 wt) or a functional fragment thereof, and comprising at least one amino acid substitution R31L and the use thereof in the cell biology research, regenerative medicine and related medical applications or cosmetics. Further it discloses a culture medium comprising subjected FGF2 suitable for culturing a human pluripotent stem cells involving both human embryonic stem cells and induced pluripotent stem cells.Type: GrantFiled: October 3, 2016Date of Patent: September 5, 2023Assignees: Masarykova Univerzita, Enantis s.r.o.Inventors: Petr Dvorak, Pavel Krejci, Lukas Balek, Livia Eiselleova, Zaneta Konecna, Pavel Dvorak, David Bednar, Jan Brezovsky, Eva Sebestova, Radka Chaloupkova, Veronika Stepankova, Pavel Vanacek, Zbynek Prokop, Jiri Damborsky, Michaela Bosakova
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Patent number: 11584742Abstract: Compounds represented by the structural formula (1) R1, R2, R3, R4, R5, R6 are inhibitors of nucleases, and are useful in particular in a method of treatment and/or prevention of proliferative diseases, neurodegenerative diseases, and other genomic instability associated diseases.Type: GrantFiled: April 15, 2019Date of Patent: February 21, 2023Assignee: MASARYKOVA UNIVERZITAInventors: Kamil Paruch, Benoit Carbain, Stepan Havel, Jiri Damborsky, Jan Brezovsky, Lukas Daniel, Alexandra Sisakova, Fedor Nikulenkov, Lumir Krejci
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Publication number: 20220002282Abstract: Compounds represented by the structural formula (1) R1, R2, R3, R4, R5, R6 are inhibitors of nucleases, and are useful in particular in a method of treatment and/or prevention of proliferative diseases, neurodegenerative diseases, and other genomic instability associated diseases.Type: ApplicationFiled: April 15, 2019Publication date: January 6, 2022Applicant: MASARYKOVA UNIVERZITAInventors: Kamil PARUCH, Benoit CARBAIN, Stepan HAVEL, Jiri DAMBORSKY, Jan BREZOVSKY, Lukas DANIEL, Alexandra SISAKOVA, Fedor NIKULENKOV, Lumir KREJCI
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Publication number: 20200270320Abstract: The invention provides an isolated thermostable polypeptide possessing FGF2 activity and having at least 85% sequence identity to SEQ ID NO: 2 (FGF2 wt) or a functional fragment thereof, and comprising at least one amino acid substitution R31L and the use thereof in the cell biology research, regenerative medicine and related medical applications or cosmetics. Further it discloses a culture medium comprising subjected FGF2 suitable for culturing a human pluripotent stem cells involving both human embryonic stem cells and induced pluripotent stem cells.Type: ApplicationFiled: October 3, 2016Publication date: August 27, 2020Inventors: Petr Dvorak, Pavel Krejci, Lukas Balek, Livia Eiselleova, Zaneta Konecna, Pavel Dvorak, David Bednar, Jan Brezovsky, Eva Sebestova, Radka Chaloupkova, Veronika Stepankova, Pavel Vanacek, Zbynek Prokop, Jiri Damborsky, Michaela Bosakova
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Patent number: 9969741Abstract: The invention provides compounds represented by the structural formula (1): wherein R1, R2, R3 and R4 are as defined in the claims. The compounds are inhibitors of nucleases, and are useful in particular in a method of treatment and/or prevention of proliferative diseases, neurodegenerative diseases, and other genomic instability associated diseases.Type: GrantFiled: June 17, 2015Date of Patent: May 15, 2018Assignee: MASARYKOVA UNIVERZITAInventors: Jiri Damborsky, Fedor Nikulenkov, Alexandra Sisakova, Stepan Havel, Lumir Krejci, Benoit Carbain, Jan Brezovsky, Lukas Daniel, Kamil Paruch
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Publication number: 20170197966Abstract: The invention provides compounds represented by the structural formula (1): wherein R1, R2, R3 and R4 are as defined in the claims. The compounds are inhibitors of nucleases, and are useful in particular in a method of treatment and/or prevention of proliferative diseases, neurodegenerative diseases, and other genomic instability associated diseases.Type: ApplicationFiled: June 17, 2015Publication date: July 13, 2017Applicant: MASARYKOVA UNIVERZITAInventors: JIRI DAMBORSKY, Fedor NIKULENKOV, Alexandra SISAKOVA, Stepan HAVEL, Lumir KREJCI, Benoit CARBAIN, Jan BREZOVSKY, Lukas DANIEL, Kamil PARUCH
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Patent number: 8580932Abstract: Thermostabilization of a protein where the protein contains access routes and wherein at least one amino acid in the bottleneck of the access route is mutated, includes identifying the amino acids of the bottleneck and the amino acids control exchange of the solvent between a buried protein core and surrounding environment and/or in the packing of the amino acids inside the access route. Modification of the amino acids are determined so that the packing of the amino acids inside the tunnel is improved and the access route prevents access of undesired solvent molecules to the protein core, while allowing passage of the compounds necessary at the protein core to enable the protein to perform its biological function.Type: GrantFiled: September 5, 2012Date of Patent: November 12, 2013Assignee: Masarykova UniverzitaInventors: Jiri Damborsky, Zbynek Prokop, Tana Koudelakova, Veronika Stepankova, Radka Chaloupkova, Eva Chovancova, Artur Wiktor Gora, Jan Brezovsky
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Publication number: 20130102763Abstract: Thermostabilization of a protein where the protein contains access routes and wherein at least one amino acid in the bottleneck of the access route is mutated, includes identifying the amino acids of the bottleneck and the amino acids control exchange of the solvent between a buried protein core and surrounding environment and/or in the packing of the amino acids inside the access route. Modification of the amino acids are determined so that the packing of the amino acids inside the tunnel is improved and the access route prevents access of undesired solvent molecules to the protein core, while allowing passage of the compounds necessary at the protein core to enable the protein to perform its biological function.Type: ApplicationFiled: September 5, 2012Publication date: April 25, 2013Inventors: Jiri DAMBORSKY, Zbynek PROKOP, Tana KOUDELAKOVA, Veronika STEPANKOVA, Radka CHALOUPKOVA, Eva CHOVANCOVA, Artur Wiktor GORA, Jan BREZOVSKY
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Patent number: 7888103Abstract: The method of detoxification of yperite—bis(2-chloroethyl)sulfide—by the use of a haloalkane dehalogenases or their compositions, the method of preparation of dehalogenationating enzymes and of decontamination compositions which contains at least one wild type and/or modified haloalkane dehalogenase (EC 3.8.1.5) as an chemically active component. The preferred dehalogenases are LinB from Sphingomonas paucimobilis UT26, DhaA from Rhodococcus rodochrous NCIMB 13064, DmbA from Mycobacterium bovis 5033/66. Decontamination is utilizable for detoxification of yperite from the surfaces of instrumentality, constructional objects, human or animal skin and elements of environment by the treatment of yperite with the detoxification composition according the invention at +10° C. to +70° C., preferably at about +40° C. and pH from 4 to 12.Type: GrantFiled: June 1, 2006Date of Patent: February 15, 2011Assignee: Masarykova UniverzitaInventors: Zbynek Prokop, Jiri Damborsky, Frantisek Oplustil, Andrea Jesenska, Yuji Nagata
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Patent number: 7632666Abstract: A method of production of optically active compounds, particularly halohydrocarbons, haloalcohols, alcohols, halopolyols and polyols using hydrolytic dehalogenation of racemic or prochiral halegenhydrocarbons by dehalohenation catalysed by haloalkane dehalogenases (the enzyme code number EC 3.8.1.5) where at least one wild type or modified haloalkane dehalogenase is applied to at least one racemic or prochiral chlorinated, brominated or iodinated compound at the temperature ranged between +10 and +70° C. and pH value between 4.0 and 12.0, in aqueous system or in a monophasic organic solution or in a monophasic organic/aqueous solution or in organic/aqueous biphasic systems.Type: GrantFiled: August 24, 2007Date of Patent: December 15, 2009Assignee: Masarykova Univerzita V BrneInventors: Zbynek Prokop, Jiri Damborsky, Dick B. Janssen, Yuji Nagata
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Publication number: 20090155868Abstract: A method of production of optically active compounds, particularly halohydrocarbons, haloalcohols, alcohols, halopolyols and polyols using hydrolytic dehalogenation of racemic or prochiral halegenhydrocarbons by dehalohenation catalysed by haloalkane dehalogenases (EC 3.8.1.5) where at least one wild type or modified haloalkane dehalogenase is affected by at least one racemic or prochiral chlorinated, brominated or iodinated compound at the temperature ranged between +10 and +70° C. and pH value between 4.0 and 12.0, in aqueous system or in a monophasic organic solution or in a monophasic organic/aqueous solution or in organic/aqueous biphasic systems.Type: ApplicationFiled: December 23, 2005Publication date: June 18, 2009Applicant: MASARYKOVA UNIVERZITA V BRNEInventors: Zbynek Prokop, Jiri Damborsky, Dick B. Janssen, Yuji Nagata
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Publication number: 20080248557Abstract: The method of detoxification of yperite—bis(2-chloroethyl)sulfide—by the use of a haloalkane dehalogenases or their compositions, the method of preparation of dehalogenationating enzymes and of decontamination compositions which contains at least one wild type and/or modified haloalkane dehalogenase (EC 3.8.1.5) as an chemically active component. The preferred dehalogenases are LinB from Sphingomonas paucimobilis UT26, DhaA from Rhodococcus rodochrous NCIMB 13064, DmbA from Mycobacterium bovis 5033/66. Decontamination is utilizable for detoxification of yperite from the surfaces of instrumentality, constructional objects, human or animal skin and elements of environment by the treatment of yperite with the detoxification composition according the invention at +10° C. to +70° C., preferably at about +40° C. and pH from 4 to 12.Type: ApplicationFiled: June 1, 2006Publication date: October 9, 2008Inventors: Zbynek Prokop, Jiri Damborsky, Frantisek Oplustil, Andrea Jesenska, Yuji Nagata
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Publication number: 20080102501Abstract: A method of production of optically active compounds, particularly halohydrocarbons, haloalcohols, alcohols, halopolyols and polyols using hydrolytic dehalogenation of racemic or prochiral halegenhydrocarbons by dehalohenation catalysed by haloalkane dehalogenases (the enzyme code number EC 3.8.1.5) where at least one wild type or modified haloalkane dehalogenase is applied to at least one racemic or prochiral chlorinated, brominated or iodinated compound at the temperature ranged between +10 and +70° C. and pH value between 4.0 and 12.0, in aqueous system or in a monophasic organic solution or in a monophasic organic/aqueous solution or in organic/aqueous biphasic systems.Type: ApplicationFiled: August 24, 2007Publication date: May 1, 2008Applicant: MASARYKOVA UNIVERZITA V BRNEInventors: Zbynek PROKOP, Jiri DAMBORSKY, Dick JANSSEN, Yuji NAGATA