Abstract: The present invention relates to the preparation and use of copolymers composed of N-(2-hydroxypropyl) methacrylamide (HPMAA) and carboxybetaine methacrylamide (CBMAA). The invention further describes polymer brushes having structure I S—R-polymer??(I) wherein S is a substrate; R is a residue of a polymerization initiator or a RAFT agent bound to the substrate; and “polymer” is the copolymer of N-(2-hydroxypropyl) methacrylamide and carboxybetaine methacrylamide Furthermore, production of these polymer brushes, containing random or block copolymers grafted to or from a substrate is described. The copolymer brushes are suitable for protecting substrates from deposition and/or adhesion of biological substances, and/or against thrombus formation. The brushes functionalized by covalent attachment of bioactive substances to CBMAA monomer units are particularly suitable for specific interaction with target biological substances which is not affected by nonspecific deposition of non-target compounds.

Abstract: The present invention relates to the preparation and use of copolymers composed of N-(2-hydroxypropyl) methacrylamide (HPMAA) and carboxybetaine methacrylamide (CBMAA). The invention further describes polymer brushes having structure I S-R-polymer ??(I) wherein S is a substrate; R is a residue of a polymerization initiator or a RAFT agent bound to the substrate; and “polymer” is the copolymer of N-(2-hydroxypropyl) methacrylamide and carboxybetaine methacrylamide Furthermore, production of these polymer brushes, containing random or block copolymers grafted to or from a substrate is described. The copolymer brushes are suitable for protecting substrates from deposition and/or adhesion of biological substances, and/or against thrombus formation. The brushes functionalized by covalent attachment of bioactive substances to CBMAA monomer units are particularly suitable for specific interaction with target biological substances which is not affected by nonspecific deposition of non-target compounds.

Abstract: A surface plasmon resonance coupler and disperser system is provided. A sensor element includes a diffraction grating having a periodically modulated surface. A light source faces the sensor element and emits an optical wave through a collimating element, which is provided in optical alignment with the light source. The optical wave is projected directly onto the periodically modulated surface of the diffraction grating. A detector faces the diffracting grating and is in receipt of the optical wave that is diffracted off the sensor element.

Abstract: A method and system for spectroscopy of surface plasmons is presented. An electromagnetic wave is made incident on a diffraction grating. Surface plasmons are excited on a medium coincident to the diffraction grating and dispersion of a wavelength spectrum of the electromagnetic wave are simultaneously performed through diffraction. Changes in spatial distribution of intensity in the wavelength spectrum of the diffracted electromagnetic wave due to the excitation of the surface plasmons are measured.

Abstract: A method and system for spectroscopy of surface plasmons is presented. An electromagnetic wave is made incident on a diffraction grating. Surface plasmons are excited on a medium coincident to the diffraction grating and dispersion of a wavelength spectrum of the electromagnetic wave are simultaneously performed through diffraction. Changes in spatial distribution of intensity in the wavelength spectrum of the diffracted electromagnetic wave due to the excitation of the surface plasmons are measured.