Patents by Inventor Jiri Jiracek

Jiri Jiracek has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Peptide derivatives usable as zinc endopeptidase 24-15 inhibitors
    Patent number: 5776903
    Abstract: Peptide derivatives usable as zinc endopeptidase 24-15 inhibitors.These peptide derivatives have the following amino acid sequence:-Phe.psi.(PO.sub.2 CH.sub.2)-.sub.(L,D) Xaa'-Yaa'-Zaa'-in which .psi.(PO.sub.2 CH.sub.2) indicates that the peptide bond (CONH) has been replaced by the phosphine bond (PO.sub.2 CH.sub.2), Xaa' and Zaa', which can be the same or different, in each case represent a natural amino acid or an amino pseudo-acid and Yaa' represents Arg or Lys.As examples of such derivatives, reference can be made to those of formula:Z-.sub.(L,D) Phe.psi.(PO.sub.2 CH.sub.2)-.sub.(L,D) -Gly-Arg-MetOHZ-.sub.(L,D) Phe.psi.(PO.sub.2 CH.sub.2)-.sub.(L,D) -Ala-Arg-MetOHZ-.sub.(L,D) Phe.psi.(PO.sub.2 CH.sub.2)-.sub.(L,D) -Ala-Arg-PheOHwith Z representing the benzyloxycarbonyl group.
    Type: Grant
    Filed: January 24, 1996
    Date of Patent: July 7, 1998
    Assignee: Commissariat A l'Energie Atomique
    Inventors: Vincent Dive, Jiri Jiracek, Athanasios Yiotakis