Patents by Inventor Jiri Kasparec

Jiri Kasparec has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 2,4,5-Trisubstituted pyrimidine compounds
    Patent number: 7759486
    Abstract: Novel substituted 2,4,8-trisubstituted-8H-pyrido[2,3-d]pyrimidin-7-one compounds and compositions for use in therapy as CSBP/p38 kinase inhibitors.
    Type: Grant
    Filed: August 16, 2007
    Date of Patent: July 20, 2010
    Assignee: GlaxoSmithKline LLC
    Inventors: Jerry L. Adams, Jeffrey C. Boehm, Ralph Hall, Qi Jin, Jiri Kasparec, Domingos J. Silva, John J. Taggart
  • ANTHRANILAMIDE INHIBITORS OF AURORA KINASE
    Publication number: 20100016318
    Abstract: The present invention relates to a compound represented by the following formula: or a pharmaceutically acceptable salt thereof; wherein R1, R1? R2, R3, R4, R5, r and s are as defined herein. Compounds of the present invention are useful in the treatment of diseases associated with Aurora kinase activity such as cancer.
    Type: Application
    Filed: January 25, 2008
    Publication date: January 21, 2010
    Applicant: SMITHKLINE BEECHAM CORPORATION
    Inventors: Jeffrey Michael Axten, Deborah L. Bryan, David Harold Drewry, Thomas H. Faitg, Timothy Francis Gallagher, Neil W. Johnson, Jiri Kasparec, Jeffrey M. Ralph, Domingos J. Silva
  • NOVEL COMPOUNDS
    Publication number: 20090105478
    Abstract: Novel substituted 2,4,8-trisubstituted-8H-pyrido[2,3-d]pyrimidin-7-one compounds and compositions for use in therapy as CSBP/p38 kinase inhibitors.
    Type: Application
    Filed: August 16, 2007
    Publication date: April 23, 2009
    Inventors: JERRY L. ADAMS, JEFFREY C. BOEHM, RALPH HALL, QI JIN, JIRI KASPAREC, DOMINGOS J. SILVA, JOHN J. TAGGART
  • SUBSTITUTED PYRAZOLOPYRIMIDINES
    Publication number: 20090029989
    Abstract: Pyrazolo-pyrimidine derivatives are described herein. The described invention also includes methods of making such derivatives as well as methods of using the same in the treatment of diseases.
    Type: Application
    Filed: July 8, 2008
    Publication date: January 29, 2009
    Inventors: Jerry Leroy Adams, Jiri Kasparec, Domingos J. Silva, Catherine C. K. Yuan
  • CHEMICAL COMPOUNDS
    Publication number: 20090012309
    Abstract: Pyrazole derivatives are described herein. The described invention also includes methods of making such pyrazole derivatives as well as methods of using the same in the treatment of diseases.
    Type: Application
    Filed: October 30, 2007
    Publication date: January 8, 2009
    Inventors: Jerry Leroy Adams, Jiri Kasparec, Domingos J. Silva
  • Novel Process and Formulations
    Publication number: 20080268044
    Abstract: The present invention provides for a novel process of making 6-carboxylic acid derivatives of pyrido[2,3-d]pyrimidin-7-one's, as well as a novel process for making 8-(2,6-difluorophenyl)-4-(4-fluoro-2-methylphenyl)-2-{[2-hydroxy-1-(hydroxymethyl)ethyl]-amino}pyrido[2,3-d]pyrimidin-7(8H)-one, and salts thereof.
    Type: Application
    Filed: November 15, 2006
    Publication date: October 30, 2008
    Inventors: John Robert George Appleby, Philip Blatcher, Ann M. Diederich, Lesley Anne Humphries, Jiri Kasparec, As'ad Abu Khalil, Richard S. Lloyd, Paul G. Spoors, John J. Taggart, Lois E. Vernon
  • Novel Chemical Compounds
    Publication number: 20080214455
    Abstract: This invention relates to newly identified compounds for inhibiting hYAK3 proteins and methods for treating diseases associated with hYAK3 activity.
    Type: Application
    Filed: May 3, 2006
    Publication date: September 4, 2008
    Inventors: Kevin Duffy, Deping Chai, Mirela Colon, Duke M. Fitch, Sarah Rae King, Antony N. Shaw, Rosanna Tedesco, Kenneth Wiggall, Michael N. Zimmerman, Neil W. Johnson, Jiri Kasparec
  • NOVEL COMPOUNDS
    Publication number: 20080032969
    Abstract: Novel substituted 2,4,8-trisubstituted-8H-pyrido[2,3-d]pyrimidin-7-one compounds and compositions for use in therapy as CSBP/p38 kinase inhibitors.
    Type: Application
    Filed: August 16, 2007
    Publication date: February 7, 2008
    Inventors: Jerry Adams, Jefrrey Boehm, Ralph Hall, Qi Jin, Jiri Kasparec, Domingos Silva, John Taggart
  • NOVEL COMPOUNDS
    Publication number: 20080033170
    Abstract: Novel substituted 2,4,8-trisubstituted-8H-pyrido[2,3-d]pyrimidin-7-one compounds and compositions for use in therapy as CSBP/p38 kinase inhibitors.
    Type: Application
    Filed: August 16, 2007
    Publication date: February 7, 2008
    Inventors: Jerry Adams, Jeffrey Boehm, Ralph Hall, Qi Jin, Jiri Kasparec, Domingos Silva, John Taggart
  • 2,4,8-trisubstituted-8H-pyrido[2,3-d]pyrimidin-7-one compounds
    Patent number: 7323472
    Abstract: The present invention is directed to the novel use of a CSBP/p38 inhibitor for the treatment, including prophylaxis of inflammation enhanced cough in a mammal in need thereof.
    Type: Grant
    Filed: October 23, 2001
    Date of Patent: January 29, 2008
    Assignee: SmithKline Beecham Corporation
    Inventors: Jerry L. Adams, Jeffrey C. Boehm, Ralph Hall, Qi Jin, Jiri Kasparec, Domingos J. Silva, John J. Taggart
  • 2,4,8-trisubstituted-8H-pyrido[2,3-d]pyrimidin-7-one compounds
    Patent number: 7314881
    Abstract: Novel substituted 2,4,8-trisubstituted-8H-pyrido[2,3-d]pyrimidin-7-one compounds and compositions for use in therapy as CSBP/p38 kinase inhibitors.
    Type: Grant
    Filed: April 6, 2004
    Date of Patent: January 1, 2008
    Assignee: SmithKline Beecham Corporation
    Inventors: Jerry L. Adams, Jeffrey C. Boehm, Ralph Hall, Qi Jin, Jiri Kasparec, Domingos J. Silva, John J. Taggart
  • 4-amino substituted-6-aryl/heteroaryl substituted-2-methylsulfanyl-pyrimidine-5-carbaldehyde intermediates
    Patent number: 7314934
    Abstract: Novel substituted 2,4,8-trisubstituted-8H-pyrido[2,3-d]pyrimidin-7-one compounds and compositions for use in therapy as CSBP/p38 kinase inhibitors.
    Type: Grant
    Filed: August 19, 2003
    Date of Patent: January 1, 2008
    Assignee: SmithKline Beecham Corporation
    Inventors: Jerry L. Adams, Jeffrey C. Boehm, Ralph Hall, Qi Jin, Jiri Kasparec, Domingos J. Silva, John J. Taggart
  • Substituted Pyrazolopyrimidines
    Publication number: 20070293489
    Abstract: Pyrazolo-pyrimidine derivatives are described herein. The described invention also includes methods of making such derivatives as well as methods of using the same in the treatment of diseases.
    Type: Application
    Filed: May 11, 2007
    Publication date: December 20, 2007
    Inventors: Jerry Adams, Jiri Kasparec, Domingos Silva, Catherine Yuan
  • Chemical compounds
    Patent number: 7307097
    Abstract: Pyrazole derivatives are described herein. The described invention also includes methods of making such pyrazole derivatives as well as methods of using the same in the treatment of diseases.
    Type: Grant
    Filed: September 25, 2002
    Date of Patent: December 11, 2007
    Assignee: SmithKline Beechman Corporation
    Inventors: Jerry Leroy Adams, Jiri Kasparec, Domingos J. Silva
  • Novel Chemical Compounds
    Publication number: 20070249599
    Abstract: This invention relates to the newly identified compounds for inhibiting hYAK3 proteins and methods for treating diseases associated with the imbalance or inappropriate activity of hYAK3 proteins.
    Type: Application
    Filed: February 24, 2005
    Publication date: October 25, 2007
    Inventors: Kevin Duffy, Duke Fitch, Steven Goodman, Masaichi Hasegawa, Neil Johnson, Jiri Kasparec, Antony Shaw
  • Substituted pyrazolopyrimidines
    Patent number: 7217710
    Abstract: Pyrazolo-pyrimidine derivatives are described herein. The described invention also includes methods of making such derivatives as well as methods of using the same in the treatment of diseases.
    Type: Grant
    Filed: October 1, 2002
    Date of Patent: May 15, 2007
    Assignee: SmithKline Beecham Corporation
    Inventors: Jerry Leroy Adams, Jiri Kasparec, Domingos J. Silva, Catherine C. K. Yuan
  • Chemical compounds
    Publication number: 20060241149
    Abstract: Pyridinyl-benzoheterocycyl kinase inhibitor compounds are disclosed. Also disclosed are methods of making such compounds as well as methods of using the same in the treatment of diseases.
    Type: Application
    Filed: November 6, 2003
    Publication date: October 26, 2006
    Inventors: Jerry Adams, Deborah Bryan, Jiri Kasparec, Francis King, Andrew Takle, David Wilson, Steven Goodman
  • Novel Compounds
    Publication number: 20050203109
    Abstract: Novel substituted 2,4,8-trisubstituted-8H-pyrido[2,3-d]pyrimidin-7-one compounds and compositions for use in therapy as CSBP/p38 kinase inhibitors.
    Type: Application
    Filed: August 19, 2003
    Publication date: September 15, 2005
    Inventors: Jerry Adams, Jeffrey Boehm, Ralph Hall, Qi Jin, Jiri Kasparec, Domingos Silva, John Taggart
  • Novel compounds
    Publication number: 20040209901
    Abstract: Novel substituted 2,4,8-trisubstituted-8H-pyrido[2,3-d]pyrimidin-7-one compounds and compositions for use in therapy as CSBP/p38 kinase inhibitors.
    Type: Application
    Filed: April 6, 2004
    Publication date: October 21, 2004
    Applicant: SmithKline Beecham Corporation
    Inventors: Jerry L. Adams, Jeffrey C. Boehm, Ralph Hall, Qi Jin, Jiri Kasparec, Domingos J. Silva, John J. Taggart
  • Chemical compounds
    Publication number: 20040198986
    Abstract: Pyrazole derivatives are described herein. The described invention also includes methods of making such pyrazole derivatives as well as methods of using the same in the treatment of diseases.
    Type: Application
    Filed: March 26, 2004
    Publication date: October 7, 2004
    Inventors: Jerry Leroy Adams, Jiri Kasparec, Domingo J Silva