Patents by Inventor Jiri Novotny
Jiri Novotny has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20170081996Abstract: A valve train assembly has at least a camshaft with at least a first cam body and a second cam body, each axially movable over the camshaft between a first axial position and a second axial position and each earn body being provided with a first cam for controlling a valve in the first axial position and a second cam for controlling the valve in the second axial position; and one or more couplers for coupling the movement of the cam bodies. A first groove extends along a part of the circumference of the first cam body. A second groove extends along a part of the circumference of the second cam body, An engager for engaging alternately the first. and second groove is included, such that either the first cam body is moved to the first axial position or the second cam body is moved to the second axial position.Type: ApplicationFiled: March 17, 2015Publication date: March 23, 2017Inventor: Jiri Novotny
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Patent number: 7991563Abstract: The relationship between an amino acid sequence of a protein and its three-dimensional structure is at the very core of structural biology and bioinformatics. The occurrence and conservation of non-canonical conformations is a “local” phenomenon, i.e., non-canonical conformations are encoded intra-helically by short peptide sequences (heptapeptides at most). Effective descriptors can be formed for these short sequences employing training sets. Multiple, distinct patterns are created representing these sequences. A composite descriptor is formed by selecting from among the patterns discovered. The composite descriptor has a high level of sensitivity and specificity while, at the same time, a boosted signal-to-noise ratio.Type: GrantFiled: September 10, 2007Date of Patent: August 2, 2011Assignee: International Business Machines CorporationInventors: Isidore Rigoutsos, Peter Riek, Robert M. Graham, Jiri Novotny
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Patent number: 7895024Abstract: The relationship between an amino acid sequence of a protein and its three-dimensional structure is at the very core of structural biology and bioinformatics. The occurrence and conservation of non-canonical conformations is a “local” phenomenon, i.e., non-canonical conformations are encoded intra-helically by short peptide sequences (heptapeptides at most). Effective descriptors can be formed for these short sequences employing training sets. Multiple, distinct patterns are created representing these sequences. A composite descriptor is formed by selecting from among the patterns discovered. The composite descriptor has a high level of sensitivity and specificity while, at the same time, a boosted signal-to-noise ratio.Type: GrantFiled: September 10, 2007Date of Patent: February 22, 2011Assignee: International Business Machines CorporationInventors: Isidore Rigoutsos, Peter Riek, Robert M. Graham, Jiri Novotny
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Patent number: 7698067Abstract: The relationship between an amino acid sequence of a protein and its three-dimensional structure is at the very core of structural biology and bioinformatics. The occurrence and conservation of non-canonical conformations is a “local” phenomenon, i.e., non-canonical conformations are encoded intra-helically by short peptide sequences (heptapeptides at most). Effective descriptors can be formed for these short sequences employing training sets. Multiple, distinct patterns are created representing these sequences. A composite descriptor is formed by selecting from among the patterns discovered. The composite descriptor has a high level of sensitivity and specificity while, at the same time, a boosted signal-to-noise ratio.Type: GrantFiled: November 27, 2002Date of Patent: April 13, 2010Assignee: International Business Machines CorporationInventors: Isidore Rigoutsos, Peter Riek, Robert M. Graham, Jiri Novotny
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Publication number: 20080171904Abstract: The relationship between an amino acid sequence of a protein and its three-dimensional structure is at the very core of structural biology and bioinformatics. The occurrence and conservation of non-canonical conformations is a “local” phenomenon, i.e., non-canonical conformations are encoded intra-helically by short peptide sequences (heptapeptides at most). Effective descriptors can be formed for these short sequences employing training sets. Multiple, distinct patterns are created representing these sequences. A composite descriptor is formed by selecting from among the patterns discovered. The composite descriptor has a high level of sensitivity and specificity while, at the same time, a boosted signal-to-noise ratio.Type: ApplicationFiled: September 10, 2007Publication date: July 17, 2008Applicant: International Business Machines CorporationInventors: Isidore Rigoutsos, Peter Riek, Robert M. Graham, Jiri Novotny
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Publication number: 20080133142Abstract: The relationship between an amino acid sequence of a protein and its three-dimensional structure is at the very core of structural biology and bioinformatics. The occurrence and conservation of non-canonical conformations is a “local” phenomenon, i.e., non-canonical conformations are encoded intra-helically by short peptide sequences (heptapeptides at most). Effective descriptors can be formed for these short sequences employing training sets. Multiple, distinct patterns are created representing these sequences. A composite descriptor is formed by selecting from among the patterns discovered. The composite descriptor has a high level of sensitivity and specificity while, at the same time, a boosted signal-to-noise ratio.Type: ApplicationFiled: September 10, 2007Publication date: June 5, 2008Applicant: International Business Machines CorporationInventors: Isidore Rigoutsos, Peter Riek, Robert M. Graham, Jiri Novotny
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Publication number: 20030157524Abstract: The relationship between an amino acid sequence of a protein and its three-dimensional structure is at the very core of structural biology and bioinformatics. The occurrence and conservation of non-canonical conformations is a “local” phenomenon, i.e., non-canonical conformations are encoded intra-helically by short peptide sequences (heptapeptides at most). Effective descriptors can be formed for these short sequences employing training sets. Multiple, distinct patterns are created representing these sequences. A composite descriptor is formed by selecting from among the patterns discovered. The composite descriptor has a high level of sensitivity and specificity while, at the same time, a boosted signal-to-noise ratio.Type: ApplicationFiled: November 27, 2002Publication date: August 21, 2003Applicant: International Business Machines CorporationInventors: Isidore Rigoutsos, Peter Riek, Robert M. Graham, Jiri Novotny
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Patent number: 6416971Abstract: Soluble, single chain T cell receptors, nucleic acid sequences, particularly DNA sequences, encoding the soluble, single chain T cell receptor, expression vectors containing the DNA sequences, and host cells containing the expression vectors.Type: GrantFiled: May 8, 1991Date of Patent: July 9, 2002Assignees: E.R. Squibb & Sons, Inc., Dana Farber Cancer InstituteInventors: Ellis L. Reinherz, Jiri Novotny, Stephen T. Smiley, Ping Li, Ramesh Ganju
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Patent number: 6403356Abstract: New mutant penicillin G acylases preferably from E. coli are provided, exhibiting altered enzymatic activity. These penicillin G acylases are obtained by expression of a gene encoding said penicillin G acylase having an amino acid sequence which differs at least in one amino acid from the wild-type penicillin G acylase.Type: GrantFiled: October 31, 1997Date of Patent: June 11, 2002Assignee: Bristol-Myers Squibb Co.Inventors: Li You, John James Usher, Brenda Joyce White, Jiri Novotny
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Patent number: 6114506Abstract: The present invention relates to a novel alpha-2-antiplasmin-binding molecules and treatment for pulmonary embolism, myocardial infarction, thrombosis or stroke in a patient which comprises administering an alpha-2-antiplasmin-binding molecule capable of preventing inhibition of plasmin by endogenous alpha-2-antiplasmin. The invention also relates to a treatment for pulmonary embolism, myocardial infarction, thrombosis or stroke in a patient comprising coadministrating an alpha-2-antiplasmin-binding molecule of the invention together with a thrombolytic agent.Type: GrantFiled: September 19, 1997Date of Patent: September 5, 2000Assignees: General Hospital Corporation, President and Fellows of Harvard College, Bristol-Myers Squibb CompanyInventors: Guy L. Reed, Linda Harris, Jurgen Bajorath, Gary Matsueda, Mei-Yin Hsu, Jiri Novotny
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Patent number: 4459850Abstract: Apparatus for picking-up and analyzing emitted accoustic and ultrasonic signals by means of a piezoelectric pick-up element connected to an amplifier with high input resistance, the output of the amplifier being connected for further evaluation to selective circuits and to an evaluation device. The piezoelectric pick-up element is situated in a casing, said casing being fixed to a hollow body being tested as by a strap encompassing at least partly both the casing and the tested hollow body.Type: GrantFiled: September 22, 1981Date of Patent: July 17, 1984Assignee: CKD Praha, oborovy podnikInventors: Blanka Hyanova, Jiri Novotny
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Patent number: D394784Type: GrantFiled: June 27, 1996Date of Patent: June 2, 1998Assignee: Crystalex a.s.Inventors: Milos Janku, Jiri Novotny
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Patent number: D395197Type: GrantFiled: June 27, 1996Date of Patent: June 16, 1998Assignee: Crystalex a.s.Inventors: Milos Jank, Jiri Novotny