Abstract: A proteome analysis method includes using a tandem type mass spectrometer to calculate bond dissociation energy by using molecular simulation, using the bond dissociation energy to obtain prediction information including a cleavage pattern of a peptide and/or peak positions in a mass spectrum and/or the intensity ratio of the mass spectrum, and identifying a protein by using the prediction information and experiment information.

Abstract: In molecular simulation including the step of calculating non-bonding interactions in a system having particles with electric charges, using a multigrid method, upon determining the electric charges at grid points in a coarser grid of a higher level that is one step higher than the level to be observed, when a pair of grid points in the observed level, or a pair of particles in the observed level, both coincide with the grid points of the grid of the higher level, the charges at the grid points of the higher level are determined so that the energy of the pair in the higher level becomes equal to the correct energy value in the observed level.

Abstract: A proteome analysis method and a proteome analysis system, which identifies proteins by using a mass spectrometer, in particular, which has the high accuracy and the high throughput, by using predicted results of bond cleavage parts by a molecular simulation method such as an MO method, are provided. Further, at the method and the system, even when the number of samples for identification is small, the number of times of its experiment can be decreased, and peak values buried under noise in a mass spectrum are added. And at the system, even when a new protein, which has not been registered in a protein sequence database, can be identified.

Abstract: Monohydrate and trihydrate crystals of N-(2-(4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-piperidino) ethyl)-1-formyl-4-piperidinecarboxamide hydrochloride having excellent stability.

Abstract: Monohydrate and trihydrate crystals of N-(2-(4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-piperidino) ethyl)-1-formyl-4-piperidinecarboxamide hydrochloride having excellent stability.

Abstract: Monohydrate and trihydrate crystals of N-(2-(4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-piperidino) ethyl)-1-formyl-4-piperidinecarboxamide hydrochloride having excellent stability.

Abstract: Monohydrate and trihydrate crystals of N-(2-(4-(5H dibenzo [a,d]cyclohepten-5-ylidene)-piperidino)ethyl)-1-formyl-4-piperidinecarboxamide hydrochloride having excellent stability.

Abstract: An enzyme is altered by introducing an additional hydrophobic group to enhance the hydrophobic environment in the enzyme so as to interfere with entrance of a water molecule. In this connection, the site of introduction and kind of hydrophobic group to be introduced are selected on the basis of comprehensive analysis of amino acid sequence, three-dimensional structure, reaction mechanism or the like of the target enzyme. Using this method, an amino acid residue of neopullulanase derived from Bacillus stearothermophilus was replaced by another amino acid.

Abstract: A low-power consumption, high-speed electronic switching system has a pair of complementary switching means connected between opposite polarity terminals of the voltage source and an output terminal. The pair of switches provides a variable impedance for applying one or the other of the polarities and said output terminal. To speed an appearance of that polarity, an inverter is coupled between an input and an output terminal via a differentiating capacitor. The differentiated inverter output speeds the appearance of the switched output signal during the interval before the complementary input becomes effective thereat.