Patents by Inventor Jiro Takano

Jiro Takano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITION FOR COMPETITIVE INHIBITION OF OREXIN RECEPTORS
    Publication number: 20220088004
    Abstract: The present invention aims to provide a novel composition for competitively inhibiting an orexin receptor, which can inhibit binding of orexin to its receptor, and a method of inhibiting binding of orexin to its receptor. The present invention relates to, for example, a composition for competitively inhibiting an orexin receptor, containing pyrroloquinoline quinone or a salt thereof as an active ingredient.
    Type: Application
    Filed: January 16, 2020
    Publication date: March 24, 2022
    Applicant: SUNTORY HOLDINGS LIMITED
    Inventors: Shota Itoga, Hiroshi Watanabe, Jiro Takano
  • Model mouse of Alzheimer's disease expressing FAD APP 716 and use thereof
    Patent number: 7745688
    Abstract: The present invention provides a non-human model mammal of Alzheimer's disease (AD) containing chimeric amyloid precursor protein (APP) gene capable of producing human amyloid ? peptide (A?) or a living part thereof, characterized in that A?42/A?40 ratio at 8-weeks-old is about 7-fold or more (about 140-fold or more in homozygote) higher compared to that of a corresponding wild-type mammal. Moreover, the present invention provides the mammal or a living part thereof, further characterized in that the level of APP expression is not significantly different compared to the corresponding wild-type mammal, and a screening method for a prophylactic and/or therapeutic drug for AD, a biomarker in biological fluids and molecular imaging of amyloid deposition or other pathological changes in the brain for an early diagnosis of AD using the mammal or a living part thereof.
    Type: Grant
    Filed: June 20, 2007
    Date of Patent: June 29, 2010
    Assignee: Riken
    Inventors: Takaomi Saido, Nobuhisa Iwata, Takashi Saito, Takahiro Suemoto, Jiro Takano
  • MODEL ANIMAL OF ALZHEIMER'S DISEASE AND USE THEREOF
    Publication number: 20070294779
    Abstract: The present invention provides a non-human model mammal of Alzheimer's disease (AD) containing chimeric amyloid precursor protein (APP) gene capable of producing human amyloid ? peptide (A?) or a living part thereof, characterized in that A?42/A?40 ratio at 8-weeks-old is about 7-fold or more (about 140-fold or more in homozygote) higher compared to that of a corresponding wild-type mammal. Moreover, the present invention provides the mammal or a living part thereof, further characterized in that the level of APP expression is not significantly different compared to the corresponding wild-type mammal, and a screening method for a prophylactic and/or therapeutic drug for AD, a biomarker in biological fluids and molecular imaging of amyloid deposition or other pathological changes in the brain for an early diagnosis of AD using the mammal or a living part thereof.
    Type: Application
    Filed: June 20, 2007
    Publication date: December 20, 2007
    Applicant: RIKEN
    Inventors: Takaomi SAIDO, Nobuhisa IWATA, Takashi SAITO, Takahiro SUEMOTO, Jiro TAKANO
  • Process for the preparation of cyclic lactic acid oligomer
    Patent number: 6861538
    Abstract: The object of the present invention is to provide a novel method for effectively producing a cyclic lactic acid oligomer, and a cyclic lactic acid oligomer produced by the method.
    Type: Grant
    Filed: September 20, 2000
    Date of Patent: March 1, 2005
    Assignee: Amato Pharmaceutical Products, Ltd.
    Inventors: Mikio Watanabe, Jiro Takano, Yoshimi Ishihara, Masahiro Murakami
  • Process for the preparation of cyclic lactic acid oligomers
    Patent number: 6825314
    Abstract: The object of the present invention is to provide a novel method for effectively producing a cyclic lactic acid oligomer, and a cyclic lactic acid oligomer produced by the method.
    Type: Grant
    Filed: June 25, 2002
    Date of Patent: November 30, 2004
    Assignee: Amato Pharmaceutical Products, Ltd.
    Inventors: Mikio Watanabe, Jiro Takano, Yoshimi Ishihara, Masahiro Murakami