Patents by Inventor Jiro Takata
Jiro Takata has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230147196Abstract: The object of the present invention is to provide a mitochondrial dysfunction improving agent comprising a vitamin K derivative having a high deliverability to mitochondria. A mitochondrial dysfunction improving agent, neurodegeneration improving agent, amyotrophic lateral sclerosis improving agent, Alzheimer's disease improving agent, and Parkinson's disease improving agent comprising at least one of a carboxylic acid ester of an active vitamin K represented by a general formula (1) or a salt thereof, and (wherein, R1 and R2 are a hydrogen atom, respectively, or a substituent selected from glycine, N-acyl glycine, N-alkyl glycine, N,N-dialkyl glycine, N,N,N-trialkyl glycine, acyl, dicarboxylic acid hemiester, and salts thereof; and at least either of R1 and R2 is glycine, N-acyl glycine, N-alkyl glycine, N,N-dialkyl glycine, N,N,N-trialkyl glycine, acyl, dicarboxylic acid hemiester, and salts thereof. R3 is a group represented by a general formula (2), or a general formula (3).Type: ApplicationFiled: March 11, 2021Publication date: May 11, 2023Inventors: Jiro TAKATA, Kazuhisa MATSUNAGA, Yoshiharu KARUBE, Katsunori IWASAKI, Shuichi SETOGUCHI, Kazuki TERADA
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Patent number: 8299277Abstract: Administration of either a tocopherol represented by the general formula (1) or a tocotrienol compound ester derivative before or after exposure to radiation is effective in preventing or treating health disorders caused by the radiation exposure.Type: GrantFiled: November 14, 2007Date of Patent: October 30, 2012Assignees: National Institute of Radiological Sciences, Fukuoka UniversityInventors: Kazunori Anzai, Megumi Ueno, Haruko Yakumaru, Junichi Ueda, Makoto Akashi, Shizuko Kobayashi, Jiro Takata, Nobuo Ikota
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Patent number: 8242302Abstract: It is intended to provide a drug which is efficacious in treating and preventing diseases wherein ischemia or an inflammatory substance associated with ischemia participates in the onset or worsening thereof. Because of containing as the active ingredient a substance selected from among farnesol, a farnesol derivative, a tocopherol derivative, a tocotrienol derivative, pharmacologically acceptable salts thereof and solvates thereof, the above-described inhibitor of ischemic disorders can exert therapeutic and preventive effects on diseases wherein ischemia or an inflammatory substance associated with ischemia participates in the onset or worsening thereof (for example, brain infarction, brain edema, cardiac infarction, etc.) not only by the administration in the acute ischemic stage but also by the therapeutic administration in subacute and/or chronic stages after ischemia-reperfusion. It is also intended to provide a farnesol carboxylic acid ester derivative and a method of producing the same.Type: GrantFiled: September 1, 2008Date of Patent: August 14, 2012Assignee: Fukuoka UniversityInventors: Jiro Takata, Kenichi Mishima, Manabu Nakashima, Katsunori Iwasaki, Kazuhisa Matsunaga, Yoshiharu Karube, Michihiro Fujiwara
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Publication number: 20110144376Abstract: An object of the present invention is to provide dermatological agents such as whitening agents and hair growth accelerators that contain a compound having high water solubility and a specific structure capable of releasing 2,3-dimethoxy-5-methyl-1,4-dihydroxybenzene (reduced form). A dermatological agent according to the present invention contains a 2,3-dimethoxy-5-methyl-1,4-dihydroxybenzenecarboxylic acid ester derivative represented by the following general Formula (I) or a salt thereof: wherein in the Formula (I), R1, R2 and R3 are specific groups.Type: ApplicationFiled: August 20, 2008Publication date: June 16, 2011Applicant: SHOWA DENKO K.K.Inventors: Jiro Takata, Nami Akaho, Kazuhisa Matsunaga, Yoshiharu Karube, Manabu Nakashima
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Publication number: 20100217006Abstract: It is intended to provide a drug which is efficacious in treating and preventing diseases wherein ischemia or an inflammatory substance associated with ischemia participates in the onset or worsening thereof. Because of containing as the active ingredient a substance selected from among farnesol, a farnesol derivative, a tocopherol derivative, a tocotrienol derivative, pharmacologically acceptable salts thereof and solvates thereof, the above-described inhibitor of ischemic disorders can exert therapeutic and preventive effects on diseases wherein ischemia or an inflammatory substance associated with ischemia participates in the onset or worsening thereof (for example, brain infarction, brain edema, cardiac infarction, etc.) not only by the administration in the acute ischemic stage but also by the therapeutic administration in subacute and/or chronic stages after ischemia-reperfusion. It is also intended to provide a farnesol carboxylic acid ester derivative and a method of producing the same.Type: ApplicationFiled: September 1, 2008Publication date: August 26, 2010Applicant: FUKUOKA UNIVERSITYInventors: Jiro Takata, Kenichi Mishima, Manabu Nakashima, Katsunori Iwasaki, Kazuhisa Matsunaga, Yoshiharu Karube, Michihiro Fujiwara
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Publication number: 20100048512Abstract: Administration of either a tocopherol represented by the general formula (1) or a tocotrienol compound ester derivative before or after exposure to radiation is effective in preventing or treating health disorders caused by the radiation exposure.Type: ApplicationFiled: November 14, 2007Publication date: February 25, 2010Applicants: National Institute of Radiological Sciences, Fukuoka UniversityInventors: Kazunori Anzai, Megumi Ueno, Haruko Yakumaru, Junichi Ueda, Makoto Akashi, Shizuko Kobayashi, Jiro Takata, Nobuo Ikota
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Publication number: 20090240070Abstract: Disclosed is a dermatological preparation that are safe and are excellent in inhibiting and removing skin pigmentation and in inhibiting skin roughness. A dermatological preparation comprising a tocopherol aminoalkylcarboxylate and/or a salt thereof, the tocopherol aminoalkylcarboxylate being represented by Formula (I): wherein R1 is a hydrogen atom or a lower alkyl group; R2 and R3 are each independently a hydrogen atom or a methyl group; X is a cycloalkylene group of 3 to 6 carbon atoms; and n is 0 or 1.Type: ApplicationFiled: February 5, 2007Publication date: September 24, 2009Applicant: SHOWA DENKO K.K.Inventors: Harumi Kamachi, Hirobumi Aoki, Yohei Kurata, Jiro Takata
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Publication number: 20050208002Abstract: A preparation for external use on skin which comprises an active ingredient exhibiting superior effects of preventing pigmentation or eliminating pigments formed in the skin, and has a high level of safety, and in particular, a cosmetic composition exhibiting superior so-called whitening effects, are provided. The whitening cosmetic composition comprises a tocopherol alkylglycine ester and/or a salt thereof.Type: ApplicationFiled: March 6, 2003Publication date: September 22, 2005Inventors: Eiko Kato, Eiji Ogata, Tadashi Yoneda, Jiro Takata
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Publication number: 20050065206Abstract: The present invention relates to a skin preparation for external application, comprising a tocopherol aminoalkylcarboxylate ester having no substituent on the N atom and/or a salt thereof. Preferable tocopherol aminoalkylcarboxylate in the present invention is one or more compound selected from ?-tocopherol derivatives, ?-tocopherol derivatives, ?-tocopherol derivatives and ?-tocopherol derivatives. The present invention also relates to a cosmetic material comprising the skin preparation.Type: ApplicationFiled: October 28, 2002Publication date: March 24, 2005Inventors: Eiko Kato, Toshi Tsuzuki, Jiro Takata, Yoshiharu Karube, Kazuhisa Matsunaga, Shizuko Kobayashi
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Publication number: 20050048011Abstract: The present invention relates to a skin preparation for external application, comprising a tocopherol aminoalkylcarboxylate ester having a substituent on the N atom and/or a salt thereof. The preferable tocopherol aminoalkylcarboxylate ester in the present invention is one or more compound selected from ?-tocopherol derivatives, ?-tocopherol derivatives, ?-tocopherol derivatives and ?-tocopherol derivatives. The present invention also relates to a cosmetic material comprising the skin preparation for external application.Type: ApplicationFiled: October 28, 2002Publication date: March 3, 2005Inventors: Eiko Kato, Toshi Tsuzuki, Jiro Takata, Yoshiharu Karube, Kazuhisa Matsunaga, Shizuko Kobayashi
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Patent number: 6599933Abstract: The object of the present invention is to provide a tocotrienol derivative which is highly water-soluble and shows high bioavailability in the living body and &ggr;-CEHC delivering agent. (A tocotrienolcarboxylic acid ester derivative represented by the general formula (I). (wherein R2 means a carboxylic acid residue having a nitrogen substituent, and R1 and R3 mean a hydrogen atom or a methyl group.Type: GrantFiled: March 2, 2001Date of Patent: July 29, 2003Assignees: Kenko CorporationInventors: Jiro Takata, Takeshi Fukushima, Kazuhiro Imai, Yoshiharu Karube, Kazuhisa Matsunaga, Michihiro Fujiwara, Akihiro Hattori, Ryoji Hidaka, Katsunori Iwasaki, Kenichi Mishima, Shizuko Kobayashi
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Publication number: 20030027857Abstract: The object of the present invention is to provide a tocotrienol derivative which is highly water-soluble and shows high bioavailability in the living body and &ggr;-CEHC delivering agent.Type: ApplicationFiled: March 2, 2001Publication date: February 6, 2003Applicant: Jiro TakataInventors: Jiro Takata, Takeshi Fukushima, Kazuhiro Imai, Yoshiharu Karube, Kazuhisa Matsunaga, Michihiro Fujiwara, Akihiro Hattori, Ryoji Hidaka, Katsunori Iwasaki, Kenichi Mishima, Shizuko Kobayashi