Abstract: A coralline hydroxyapatite having a pore size of 30 ?m to 1300 ?m, a porosity of 50% to 70%, and a conversion rate of 50% or more, and a preparation method are disclosed. The preparation method comprises: soaking pretreated corallite in a cutting protective agent, and then cutting to obtain cut corallite, and screening for cut corallite that meets a cutting size requirement to obtain an acceptable product of cut corallite; fully soaking the acceptable product of cut corallite in a phosphate solution, and performing a hydrothermal exchange reaction to obtain the coralline hydroxyapatite; wherein the cutting protective agent is a solution containing a polyol. The preparation method can significantly improve the cutting efficiency, broaden the cutting specifications and sizes, and significantly improve the yield of acceptable product, especially the yield of acceptable small-size products, which further broadens the application range of artificial bones.

Abstract: The present disclosure provides a recombinant collagen and a recombinant collagen sponge material. The recombinant collagen comprises: (a) a protein composed of the amino acid sequence represented by SEQ ID NO: 2; and/or (b) a protein which has the same function as (a) and is derived from (a) by substitution, deletion and/or addition of one or more amino acids in SEQ ID NO:2. The recombinant collagen sponge material is obtained by sequential physical cross-linking and chemical cross-linking of the recombinant collagen. The recombinant collagen sponge material according to the present disclosure is capable of hemostasis, wound surface repair, moisture absorption and platelet aggregation, and has high moisture absorption, a significant hemostatic effect and good biocompatibility, assuming great clinical significance in the field of surgery.

Abstract: The present disclosure provides a recombinant collagen and a recombinant collagen sponge material. The recombinant collagen comprises: (a) a protein composed of the amino acid sequence represented by SEQ ID NO: 2; and/or (b) a protein which has the same function as (a) and is derived from (a) by substitution, deletion and/or addition of one or more amino acids in SEQ ID NO:2. The recombinant collagen sponge material is obtained by sequential physical cross-linking and chemical cross-linking of the recombinant collagen. The recombinant collagen sponge material according to the present disclosure is capable of hemostasis, wound surface repair, moisture absorption and platelet aggregation, and has high moisture absorption, a significant hemostatic effect and good biocompatibility, assuming great clinical significance in the field of surgery.