Abstract: The present invention relates to a transposon vector, a transposon system comprising same, a transposon kit, a cell into which the transposon vector is inserted, and uses thereof, wherein the present invention has been completed by confirming that an exogenous gene is effectively transferred into the chromosome of a target cell to produce a high yield of genetically modified cells. In particularly, it was confirmed that the transposon according to the present invention can effectively transfer a TCR or CAR-encoding gene to immune cells, and cells expressing the TCR or CAR show high reactivity to an antigen, and thus, it is expected that various TCR-T cells and CAR-T cells can be produced by using the transposon system according to the present invention.

Abstract: A refrigerator is provided. The refrigerator includes a main body including a door, a door opening device including a motor, and for opening the door using the motor, a proximity sensor, and a controller, wherein the controller is configured to detect whether an object exists within a first distance from a predetermined area of the refrigerator, identify whether the object is detected during a threshold time range, based on the object being detected during the threshold time range, identify whether the object is detected outside a second distance from the predetermined area, and based on the object being detected outside the second distance, control the motor to open the door.

Abstract: The present invention relates to a novel T-cell receptor binding to MR1, and a use thereof. Unlike a conventional customized anticancer immune T cell therapeutic agent, which are limitedly used depending on cancer type and the expression of cancer antigens according to human leukocyte antigen (HLA) type, T cells in which a T-cell receptor is expressed can be applied to all types of cancer regardless of HLA type.

Abstract: Provided herein are CAR-T compositions that are directed to GPC3, including a chimeric receptor, and engineered immune cells to GPC3. The disclosure also provides vectors, compositions, and methods of treatment using GPC3 antigen binding molecules and engineered immune cells, optionally in combination with expression of IL-18. GPC3 CAR compositions provided herein can be used for the treatment of certain cancers.

Abstract: Provided are CAR-T compositions that are directed to GPC3, including chimeric receptors, and engineered immune cells to GPC3. The disclosure also provides vectors, compositions, and methods of treatment using GPC3 antigen binding molecules and engineered immune cells. GPC3 CAR compositions provided herein can be used for the treatment of certain cancers.

Abstract: Rectangular conductor wires are often used in alternator applications requiring a high slot fill to maximize output and efficiency. However for lower output and efficiency applications, round conductor wire may increase cost competiveness in these alternators. A common lamination for a core alternatively accommodates both rectangular conductor wires and round conductor wires for different applications without any other component changes. The lamina has a slot that aligns round wire in a single row within the slot and provides a predetermined clearance from the slot opening. A stator core formed from these laminae has a relatively high slot fill factor when wound with the round wire. The same stator core can be alternatively wound with square wire to increase the slot fill factor even higher. The common lamination results in two stator configurations: a high slot fill version (round wire) and a very high slot fill version (square wire).

Abstract: Provided are CAR-T compositions that are directed to a CAR including (i) an extracellular domain comprising an antigen-binding domain; (ii) a transmembrane domain; and (iii) an intracellular domain comprising a costimulatory endodomain, wherein the costimulatory endodomain comprises an intracellular signaling domain from 4-1BB/CD137 and five additional amino acids. The disclosure also provides vectors, compositions, and methods of treatment using the antigen binding molecules and engineered immune cells comprising the CAR. The CAR compositions provided herein can be used for the treatment of certain cancers.

Abstract: A refrigerator is provided. The refrigerator includes a main body including a door, a door opening device including a motor, and for opening the door using the motor, a proximity sensor, and a controller, wherein the controller is configured to detect whether an object exists within a first distance from a predetermined area of the refrigerator, identify whether the object is detected during a threshold time range, based on the object being detected during the threshold time range, identify whether the object is detected outside a second distance from the predetermined area, and based on the object being detected outside the second distance, control the motor to open the door.

Abstract: Rectangular conductor wires are often used in alternator applications requiring a high slot fill to maximize output and efficiency. However for lower output and efficiency applications, round conductor wire may increase cost competiveness in these alternators. A common lamination for a core alternatively accommodates both rectangular conductor wires and round conductor wires for different applications without any other component changes. The lamina has a slot that aligns round wire in a single row within the slot and provides a predetermined clearance from the slot opening. A stator core formed from these laminae has a relatively high slot fill factor when wound with the round wire. The same stator core can be alternatively wound with square wire to increase the slot fill factor even higher. The common lamination results in two stator configurations: a high slot fill version (round wire) and a very high slot fill version (square wire).

Abstract: Rectangular conductor wires (38) are often used in alternator applications requiring a high slot fill to maximize output and efficiency. However for lower output and efficiency applications, round conductor (40) wire may increase cost competiveness in these alternators. A common lamination for a core (110) alternatively accommodates both rectangular conductor wires (38) and round conductor wires (40) for different applications without any other component changes. The lamina has a slot (112) that aligns round wire (40) in a single row within the slot and provides a predetermined clearance from the slot opening (126). A stator core (110) formed from these laminae has a relatively high slot fill factor when wound with the round wire (40). The same stator core (110) can be alternatively wound with square wire (38) to increase the slot fill factor even higher. The common lamination results in two stator configurations: a high slot fill version (round wire) and a very high slot fill version (square wire).

Abstract: An electric machine comprises a stator and a rotor configured to rotate about an axis of rotation in a direction of angular rotation. The rotor includes a first claw-pole segment and an opposing second claw-pole segment. The first claw-pole segment includes a plurality of first fingers extending from a first end member with an opening between each of the plurality of first fingers. The second claw-pole segment includes a plurality of second fingers extending from a second end member with an opening between each of the plurality of second fingers. A plurality of magnets are positioned on the rotor, each of the plurality of magnets positioned between a pair of first and second fingers. A molded plastic insert is positioned on the rotor, the molded plastic insert positioned in one of the openings and extending over an outer surface of each of the plurality of magnets.

Abstract: An alternator has a pole segment with a collar, an axially outward surface, and at least one key extending radially outward from the collar along the surface. A fan has a keying slot extending radially outward from a center ring, and a fan body including protrusions. The fan is mounted to the segment whereby the collar fits inside the ring and the key fits inside the keying slot, and the fan is welded to the segment at the protrusions. A method includes securing a fan to a pole segment by mating a radially-extending key formed on the segment to a keying slot of the fan and by welding the fan to the segment.

Abstract: An integrated magnetic switch assembly includes a winding assembly portion having a housing, and a cover assembly mounted to the housing. The cover assembly includes at least one rivet terminal and at least one power terminal The at least one rivet terminal includes a body that extends through the cover assembly. The body has a first end that extends to a second end, and an opening that includes a first diameter that extends from the first end to the second end. A sealing member is positioned at the first end of the body about the opening of the at least one rivet terminal. The sealing member includes an opening having a second diameter that is smaller than the first diameter. A sealing element is positioned between the at least one power terminal and the cover assembly.

Abstract: An integrated magnetic switch assembly includes a winding assembly portion having a housing, and a cover assembly mounted to the housing. The cover assembly includes at least one rivet terminal and at least one power terminal The at least one rivet terminal includes a body that extends through the cover assembly. The body has a first end that extends to a second end, and an opening that includes a first diameter that extends from the first end to the second end. A sealing member is positioned at the first end of the body about the opening of the at least one rivet terminal. The sealing member includes an opening having a second diameter that is smaller than the first diameter. A sealing element is positioned between the at least one power terminal and the cover assembly.