Patents by Inventor Jixiang Han
Jixiang Han has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240309411Abstract: The present invention relates to engineered microbial host cells comprising exogenous genes coding for proteins responsible for converting histidine and cysteine into ergothioneine in greater efficiency than the wild-type cells. Also provided in this invention are methods for producing ergothioneine using the engineered microbial host cells of the present invention.Type: ApplicationFiled: August 14, 2023Publication date: September 19, 2024Applicant: Conagen Inc.Inventors: Jixiang Han, Sonya Clarkson, David Nunn
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Patent number: 10752921Abstract: The subject technology generally relates to biosynthesis of styrene. Certain embodiments of the subject technology is based, in part, on the recognition that phenylalanine can be converted to styrene by a two-step pathway of deamination and de-carboxylation, with trans-cinnamic acid (tCA) as the intermediate. Two types of enzymes are directly involved in this process, phenylalanine ammonia lyase (PAL), which converts phenylalanine to tCA, and cinnamic acid decarboxylase, which coverts tCA to styrene. Host cells expressing these two types of enzymes can be cultured in bioreactor to produce styrene from renewable substrates such as glucose.Type: GrantFiled: September 15, 2017Date of Patent: August 25, 2020Assignee: Phytogene, Inc.Inventors: Mohammad Wadud Bhuiya, Hui Chen, Xianpeng Cai, Jixiang Han, Xiaodan Yu
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Publication number: 20200224232Abstract: Disclosed are methods for ergothioneine biosynthesis. More particularly, the present disclosure relates to methods for microbial ergothioneine biosynthesis.Type: ApplicationFiled: December 13, 2019Publication date: July 16, 2020Applicant: Conagen Inc.Inventors: Jixiang Han, Hui Chen, Oliver Yu
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Patent number: 10544437Abstract: Disclosed are methods for ergothioneine biosynthesis. More particularly, the present disclosure relates to methods for microbial ergothioneine biosynthesis. The present disclosure relates generally to engineered host cells and methods for producing ergothioneine. More particularly, the present disclosure relates to an engineered host cell and methods for microbial ergothioneine biosynthesis using the engineered host cell.Type: GrantFiled: April 28, 2015Date of Patent: January 28, 2020Assignee: Conagen Inc.Inventors: Jixiang Han, Hui Chen, Xiaodan Yu
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Publication number: 20180002726Abstract: The subject technology generally relates to biosynthesis of styrene. Certain embodiments of the subject technology is based, in part, on the recognition that phenylalanine can be converted to styrene by a two-step pathway of deamination and de-carboxylation, with trans-cinnamic acid (tCA) as the intermediate. Two types of enzymes are directly involved in this process, phenylalanine ammonia lyase (PAL), which converts phenylalanine to tCA, and cinnamic acid decarboxylase, which coverts tCA to styrene. Host cells expressing these two types of enzymes can be cultured in bioreactor to produce styrene from renewable substrates such as glucose.Type: ApplicationFiled: September 15, 2017Publication date: January 4, 2018Applicant: Phytogene, Inc.Inventors: Mohammad Wadud Bhuiya, Hui Chen, Xianpeng Cai, Jixiang Han, Xiaodan Yu
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Publication number: 20170051325Abstract: Disclosed are methods for ergothioneine biosynthesis. More particularly, the present disclosure relates to methods for microbial ergothioneine biosynthesis. The present disclosure relates generally to engineered host cells and methods for producing ergothioneine. More particularly, the present disclosure relates to an engineered host cell and methods for microbial ergothioneine biosynthesis using the engineered host cell.Type: ApplicationFiled: April 28, 2015Publication date: February 23, 2017Applicant: Conagen Inc.Inventors: Jixiang Han, Hui Chen, Xiaodan Yu
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Publication number: 20150337336Abstract: The subject technology generally relates to biosynthesis of styrene. Certain embodiments of the subject technology is based, in part, on the recognition that phenylalanine can be converted to styrene by a two-step pathway of deamination and decarboxylation, with trans-cinnamic acid (tCA) as the intermediate. Two types of enzymes are directly involved in this process, phenylalanine ammonia lyase (PAL), which converts phenylalanine to tCA, and cinnamic acid decarboxylase, which coverts tCA to styrene. Host cells expressing these two types of enzymes can be cultured in bioreactor to produce styrene from renewable substrates such as glucose.Type: ApplicationFiled: June 21, 2013Publication date: November 26, 2015Inventors: Mohammad Wadud Bhuiya, Hui Chen, Xianpeng Cai, Jixiang Han, Xiaodan Yu
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Patent number: 9181559Abstract: Transgenic plants, plant material, plant cells, and genetic constructs for synthesis of biopolymers, for example polyhydroxyalkanoates (“PHA”) are provided. In one embodiment, the transgenic plants synthesize polyhydroxybutyrate (“PHB”). In one embodiment the transgenic plant encodes siRNA for one or more of the genes encoding enzymes for producing PHA. In a more preferred embodiment, the siRNA expression is under the control of an inducible regulatory element. In another embodiment, the transgenic plant contains transgenes that encode expression enzymes that will degrade the polymer. In a preferred embodiment, the expression of these enzymes is under the control of a germination specific, inducible, or minimal promoter. In another embodiment, the transgenic plant contains transgenes encoding enzymes that increase carbon flow for polymer synthesis. In a preferred embodiment, these transgenes encode enzymes that increase carbon flow in the Calvin Cycle.Type: GrantFiled: September 15, 2010Date of Patent: November 10, 2015Assignee: Metabolix, Inc.Inventors: Nii Patterson, Jihong Tang, Jixiang Han, Venkata Tavva, Andrew Hertig, Zhigang Zhang, Thomas Martin Ramseier, Karen Bohmert-Tatarev, Oliver P. Peoples, Kristi D. Snell
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Publication number: 20120180162Abstract: Transgenic plants, plant material, plant cells, and genetic constructs for synthesis of biopolymers, for example polyhydroxyalkanoates (“PHA”) are provided. In one embodiment, the transgenic plants synthesize polyhydroxybutyrate (“PHB”). In one embodiment the transgenic plant encodes siRNA for one or more of the genes encoding enzymes for producing PHA. In a more preferred embodiment, the siRNA expression is under the control of an inducible regulatory element. In another embodiment, the transgenic plant contains transgenes that encode expression enzymes that will degrade the polymer. In a preferred embodiment, the expression of these enzymes is under the control of a germination specific, inducible, or minimal promoter. In another embodiment, the transgenic plant contains transgenes encoding enzymes that increase carbon flow for polymer synthesis. In a preferred embodiment, these transgenes encode enzymes that increase carbon flow in the Calvin Cycle.Type: ApplicationFiled: September 15, 2010Publication date: July 12, 2012Applicant: METABOLIX, INC.Inventors: Nii Patterson, Jihong Tang, Jixiang Han, Venkata Tavva, Andrew Hertig, Zhigang Zhang, Thomas Martin Ramseier, Karen Bohmert-tatarev, Oliver P. peoples, Kristi D. Snell
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Publication number: 20030159173Abstract: The invention relates to chimerical genes that have (i) a DNA sequence coding for a desired product, and (ii) an elongase promoter. The DNA sequence is functionally linked with the promoter to allow expression of the product under the control of the promoter. The invention further relates to vectors, plant cells, plants and plant parts and microorganisms that contain the chimerical gene and to methods for producing such vectors, plant cells, plants and plant parts and microorganisms. The invention also relates to elongase-encoding sequences from Brassica napus and to transgenic plants and microorganisms expressing said sequences.Type: ApplicationFiled: April 19, 2002Publication date: August 21, 2003Inventors: Frank P. Wolter, Jixiang Han, Margrit Frentzen