Patents by Inventor Jiyan Chen
Jiyan Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20130052637Abstract: Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared (NIR) spectral range. The NIR is highly sensitive for tumor detection and tracking. The application discloses targeting a tumor-enriched cell surface receptor with a ligand-conjugated fluorescent probe, which specifically allows detection of the tumor relative to the negligible animal autofluorescence.Type: ApplicationFiled: August 29, 2012Publication date: February 28, 2013Applicant: LI-COR, INC.Inventors: Joy Kovar, Jiyan Chen, Daniel R. Draney, D. Michael Olive, William M. Volcheck, Xinshe Xu, Ananda G. Lugade, Narasimhachari Narayanan
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Publication number: 20120258048Abstract: Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared (NIR) spectral range. The NIR is highly sensitive for tumor detection and tracking. The application discloses targeting a tumor-enriched cell surface receptor with a ligand-conjugated fluorescent probe, which specifically allows detection of the tumor relative to the negligible animal autofluorescence.Type: ApplicationFiled: June 15, 2012Publication date: October 11, 2012Applicant: LI-COR, INC.Inventors: Joy Kovar, Jiyan Chen, Daniel R. Draney, D. Michael Olive, William M. Volcheck, Xinshe Xu, Ananda G. Lugade, Narasimhachari Narayanan
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Patent number: 8227621Abstract: The present invention provides for cyanine dyes as near IR quenchers. The cyanine dyes have absorption wavelengths in the near-infrared region of about 650-900 nm and are essentially non-fluorescent. The dyes of the invention have at least one linking group. The present invention also provides substantially non-fluorescent, NIR probes. Biological assays based on these novel, substantially non-fluorescent, NIR probes are also provided.Type: GrantFiled: June 12, 2006Date of Patent: July 24, 2012Assignee: Li-Cor, Inc.Inventors: Xinzhan Peng, Xinshe Xu, Daniel R. Draney, Garrick M. Little, Jiyan Chen, William M. Volcheck, Charles Prescott
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Patent number: 8148516Abstract: The present invention provides compounds, methods and systems for sequencing nucleic acid using single molecule detection. Using labeled NPs that exhibit charge-switching behavior, single-molecule DNA sequencing in a microchannel sorting system is realized. In operation, sequencing products are detected enabling real-time sequencing as successive detectable moieties flow through a detection channel. By electrically sorting charged molecules, the cleaved product molecules are detected in isolation without interference from unincorporated NPs and without illuminating the polymerase-DNA complex.Type: GrantFiled: August 10, 2010Date of Patent: April 3, 2012Assignee: Pacific Biosciences of California, Inc.Inventors: John G. K. Williams, Gregory R Bashford, Jiyan Chen, Dan Draney, Nara Narayanan, Bambi L. Reynolds, Pamela Sheaff
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Publication number: 20110039266Abstract: The present invention provides compounds, methods and systems for sequencing nucleic acid using single molecule detection. Using labeled NPs that exhibit charge-switching behavior, single-molecule DNA sequencing in a microchannel sorting system is realized. In operation, sequencing products are detected enabling real-time sequencing as successive detectable moieties flow through a detection channel. By electrically sorting charged molecules, the cleaved product molecules are detected in isolation without interference from unincorporated NPs and without illuminating the polymerase-DNA complex.Type: ApplicationFiled: August 10, 2010Publication date: February 17, 2011Applicant: Pacific Biosciences of California, Inc.Inventors: John G.K. Williams, Gregory R. Bashford, Jiyan Chen, Dan Draney, Nara Narayanan, Bambi L. Reynolds, Pamela Sheaff
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Patent number: 7659070Abstract: The present invention provides compounds, methods and systems for sequencing nucleic acid using single molecule detection. Using labeled NPs that exhibit charge-switching behavior, single-molecule DNA sequencing in a microchannel sorting system is realized. In operation, sequencing products are detected enabling real-time sequencing as successive detectable moieties flow through a detection channel. By electrically sorting charged molecules, the cleaved product molecules are detected in isolation without interference from unincorporated NPs and without illuminating the polymerase-DNA complex.Type: GrantFiled: October 26, 2007Date of Patent: February 9, 2010Assignee: Pacific Biosciences of California, Inc.Inventors: John G. K. Williams, Gregory R. Bashford, Jiyan Chen, Dan Draney, Nara Narayanan, Bambi L. Reynolds, Pamela Sheaff
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Patent number: 7625701Abstract: The present invention provides compounds, methods and systems for sequencing nucleic acid using single molecule detection. Using labeled NPs that exhibit charged-switching behavior, single-molecule DNA sequencing in a microchannel sorting system is realized. In operation, sequencing products are detected enabling real-time sequencing as successive detectable moieties flow through a detection channel. By electrically sorting charged molecules, the cleaved product molecules are detected in isolation without interference from unincorporated NPs and without illuminating the polymerase-DNA complex.Type: GrantFiled: June 15, 2005Date of Patent: December 1, 2009Assignee: Pacific Biosciences of California, Inc.Inventors: John G. K. Williams, Gregory Bashford, Jiyan Chen, Dan Draney, Nara Narayanan, Bambi Reynolds, Pamela Sheaff
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Patent number: 7597878Abstract: Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared (NIR) spectral range. The NIR is highly sensitive for tumor detection and tracking. The application discloses targeting a tumor-enriched cell surface receptor with a ligand-conjugated fluorescent probe, which specifically allows detection of the tumor relative to the negligible animal autofluorescence.Type: GrantFiled: May 19, 2006Date of Patent: October 6, 2009Assignee: Li-Cor, Inc.Inventors: Joy Kovar, Jiyan Chen, Daniel R. Draney, D. Michael Olive, William M. Volcheck, Xinshe Xu, Ananda G. Lugade, Narasimhachari Narayanan
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Publication number: 20080206764Abstract: The present invention provides compounds, methods and systems for sequencing nucleic acid using single molecule detection. Using labeled NPs that exhibit charge-switching behavior, single-molecule DNA sequencing in a microchannel sorting system is realized. In operation, sequencing products are detected enabling real-time sequencing as successive detectable moieties flow through a detection channel. By electrically sorting charged molecules, the cleaved product molecules are detected in isolation without interference from unincorporated NPs and without illuminating the polymerase-DNA complex.Type: ApplicationFiled: October 26, 2007Publication date: August 28, 2008Applicant: Pacific BiosciencesInventors: John G.K. Williams, Gregory R. Bashford, Jiyan Chen, Dan Draney, Nara Narayanan, Bambi L. Reynolds, Pamela Sheaff
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Publication number: 20080153095Abstract: The present invention provides compounds, methods and systems for sequencing nucleic acid using single molecule detection. Using labeled NPs that exhibit charge-switching behavior, single-molecule DNA sequencing in a microchannel sorting system is realized. In operation, sequencing products are detected enabling real-time sequencing as successive detectable moieties flow through a detection channel. By electrically sorting charged molecules, the cleaved product molecules are detected in isolation without interference from unincorporated NPs and without illuminating the polymerase-DNA complex.Type: ApplicationFiled: October 26, 2007Publication date: June 26, 2008Applicant: Pacific BiosciencesInventors: John G.K. Williams, Gregory R. Bashford, Jiyan Chen, Dan Draney, Nara Narayanan, Bambi L. Reynolds, Pamela Sheaff
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Publication number: 20070042398Abstract: The present invention provides for cyanine dyes as near IR quenchers. The cyanine dyes have absorption wavelengths in the near-infrared region of about 650-900 nm and are essentially non-fluorescent. The dyes of the invention have at least one linking group. The present invention also provides substantially non-fluorescent, NIR probes. Biological assays based on these novel, substantially non-fluorescent, NIR probes are also provided.Type: ApplicationFiled: June 12, 2006Publication date: February 22, 2007Applicant: LI-COR, INC.Inventors: Xinzhan Peng, Xinshe Xu, Daniel Draney, Garrick Little, Jiyan Chen, William Volcheck, Charles Prescott
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Publication number: 20060280688Abstract: Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared (NIR) spectral range. The NIR is highly sensitive for tumor detection and tracking. The application discloses targeting a tumor-enriched cell surface receptor with a ligand-conjugated fluorescent probe, which specifically allows detection of the tumor relative to the negligible animal autofluorescence.Type: ApplicationFiled: May 19, 2006Publication date: December 14, 2006Applicant: LI-COR, Inc.Inventors: Joy Kovar, Jiyan Chen, Daniel Draney, D. Olive, William Volcheck, Xinshe Xu, Ananda Lugade, Narasimhachari Narayanan
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Publication number: 20060063173Abstract: The present invention provides compounds, methods and systems for sequencing nucleic acid using single molecule detection. Using labeled NPs that exhibit charge-switching behavior, single-molecule DNA sequencing in a microchannel sorting system is realized. In operation, sequencing products are detected enabling real-time sequencing as successive detectable moieties flow through a detection channel. By electrically sorting charged molecules, the cleaved product molecules are detected in isolation without interference from unincorporated NPs and without illuminating the polymerase-DNA complex.Type: ApplicationFiled: June 15, 2005Publication date: March 23, 2006Applicant: LI-COR, Inc.Inventors: John Williams, Gregory Bashford, Jiyan Chen, Dan Draney, Nara Narayanan, Bambi Reynolds, Pamela Sheaff
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Patent number: 7005518Abstract: Fluorescent dyes are disclosed which are useful as reporter groups for labeling biomolecules. The silicon phthalocyanine dyes disclosed are preferably water soluble, isomericly pure, possess high quantum yield, and are useful in bioassays.Type: GrantFiled: October 23, 2003Date of Patent: February 28, 2006Assignee: Li-Cor, Inc.Inventors: Xinzhan Peng, Daniel R. Draney, Jiyan Chen
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Patent number: 6936702Abstract: The present invention provides compounds, methods and systems for sequencing nucleic acid using single molecule detection. Using labeled NPs that exhibit charge-switching behavior, single-molecule DNA sequencing in a microchannel sorting system is realized. In operation, sequencing products are detected enabling real-time sequencing as successive detectable moieties flow through a detection channel. By electrically sorting charged molecules, the cleaved product molecules are detected in isolation without interference from unincorporated NPs and without illuminating the polymerase-DNA complex.Type: GrantFiled: June 6, 2001Date of Patent: August 30, 2005Assignee: LI-COR, Inc.Inventors: John G. K. Williams, Gregory R. Bashford, Jiyan Chen, Dan Draney, Nara Narayanan, Bambi L. Reynolds, Pamela Sheaff
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Publication number: 20040171827Abstract: Fluorescent dyes are disclosed which are useful as reporter groups for labeling biomolecules. The silicon phthalocyanine dyes disclosed are preferably water soluble, isomericly pure, possess high quantum yield, and are useful in bioassays.Type: ApplicationFiled: October 23, 2003Publication date: September 2, 2004Applicant: LI-COR, Inc.Inventors: Xinzhan Peng, Daniel R. Draney, Jiyan Chen
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Publication number: 20020042071Abstract: The present invention provides compounds, methods and systems for sequencing nucleic acid using single molecule detection. Using labeled NPs that exhibit charge-switching behavior, single-molecule DNA sequencing in a microchannel sorting system is realized. In operation, sequencing products are detected enabling real-time sequencing as successive detectable moieties flow through a detection channel. By electrically sorting charged molecules, the cleaved product molecules are detected in isolation without interference from unincorporated NPs and without illuminating the polymerase-DNA complex.Type: ApplicationFiled: June 6, 2001Publication date: April 11, 2002Inventors: John G.K. Williams, Gregory R. Bashford, Jiyan Chen, Dan Draney, Nara Narayanan, Bambi L. Reynolds, Pamela Sheaff