Abstract: There is provided in the present disclosure a shift register unit, including: an input sub-circuit, whose first terminal is coupled to an input signal terminal, and second terminal is coupled to a pull-up node; an output sub-circuit, whose first terminal is coupled to the pull-up node, second terminal is coupled to a clock signal terminal, and third terminal is coupled to an output terminal, and configured to output a clock signal of the clock signal terminal to the output terminal under the control of a level signal of the pull-up node; a first electro-static discharge sub-circuit, whose first terminal is coupled to the pull-up node, second terminal is coupled to an electro-static discharge control terminal, and third terminal is coupled to a ground, and configured to discharge static electricity accumulated at the pull-up node under the control of a level signal of the electro-static discharge control terminal.

Abstract: There is provided in the present disclosure a shift register unit, including: an input sub-circuit, whose first terminal is coupled to an input signal terminal, and second terminal is coupled to a pull-up node; an output sub-circuit, whose first terminal is coupled to the pull-up node, second terminal is coupled to a clock signal terminal, and third terminal is coupled to an output terminal, and configured to output a clock signal of the clock signal terminal to the output terminal under the control of a level signal of the pull-up node; a first electro-static discharge sub-circuit, whose first terminal is coupled to the pull-up node, second terminal is coupled to an electro-static discharge control terminal, and third terminal is coupled to a ground, and configured to discharge static electricity accumulated at the pull-up node under the control of a level signal of the electro-static discharge control terminal.

Abstract: Embodiments of the present disclosure provide a device and a method for detecting breakage of a substrate and a substrate transfer system. The device includes a first electrode and a second electrode arranged oppositely, a power source, and a detector. The power source may provide an alternating current voltage to the first electrode and the second electrode. The detector is arranged between the power source and the first electrode or the second electrode and may detect, when the substrate is placed between the first electrode and the second electrode, a current value in the substrate, and determine whether the substrate is damaged based on the detected current value.

Abstract: Described herein is a composition for converting a non-pathogenic prion protein (“PrPN”) into a prion protein in a pathogenic conformation (“PrPPath”) comprising a lipid and a polyanion. Also described are methods of (1) using the composition to convert a PrPN to a PrPPath, (2) identifying a potential therapeutic substance affecting PrPPath, and (3) diagnosing PrPPath infection in a subject using the composition and at least one cycle of protein misfolding cyclic amplification.

Abstract: The present invention provides novel polypeptides comprising a prion-aggregation domain and a second domain; novel polynucleotides encoding such polypeptides; host cells transformed or transfected with such polynucleotides; and methods of making and using the foregoing.

Abstract: The invention relates to methods of identifying, detecting or designing drugs that inhibit the formation of or accumulation of PrP, PrPSc or both in cells; to drugs that inhibit the formation of or accumulation of PrP, PrPSc or both in cells; to methods of preventing or reducing the adverse effects of PrP, PrPSc or both in humans; and to transgenic nonhuman mammals, such as transgenic mice, that ectopically express PrP.