Abstract: Bridged heterocyclyl-substituted pyrimidine compounds, a preparation method and medical use thereof. The compounds or pharmaceutical compositions comprising same can be used as JAK1 and TYK2 kinase inhibitors for treating JAK1 and TYK2 kinase activity-related diseases such as inflammations, autoimmune diseases and cancers.

Abstract: The present disclosure provides a device for separating sub-micron particles in the air, comprising a first separation channel, a second separation channel and a collection device which are connected in sequence, wherein each of the first separation channel and the second separation channel is of a rectangle structure with two open ends, the height H1 of the first separation channel is greater than the height H2 of the second separation channel, and each separation channel is provided with a vibration sound source and an antimicrobial coating layer. Based on the agglomeration theory of suspended particles in the air by ultrasonic standing waves, the device can aggregate sub-micron suspended particles flowing into each channel of the device on the upper and lower wall surfaces and the centerline of the channel, and sterilize the aggregated particles, thereby effectively removing the sub-micron suspended particles in the air.

Abstract: The present disclosure provides a device for separating sub-micron particles in the air, comprising a first separation channel, a second separation channel and a collection device which are connected in sequence, wherein each of the first separation channel and the second separation channel is of a rectangle structure with two open ends, the height H1 of the first separation channel is greater than the height H2 of the second separation channel, and each separation channel is provided with a vibration sound source and an antimicrobial coating layer. Based on the agglomeration theory of suspended particles in the air by ultrasonic standing waves, the device can aggregate sub-micron suspended particles flowing into each channel of the device on the upper and lower wall surfaces and the centerline of the channel, and sterilize the aggregated particles, thereby effectively removing the sub-micron suspended particles in the air.