Patents by Inventor Jo Ellen Feugate

Jo Ellen Feugate has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chemokines and methods for inducing the differentiation of fibroblasts to myofibroblasts
    Patent number: 6962971
    Abstract: This invention is based on the discovery that chemokines induce fibroblasts to differentiate to myofibroblasts, which play a critical role in wound healing and are implicated in a number of fibrotic diseases. This activity has been localized to a peptide in the N-terminus of several chemokines. Accordingly, the invention provides polypeptides that induce the differentiation of fibroblasts to myofibroblasts in vitro and in vivo, nucleic acids encoding such polypeptides and related vectors, host cells, and composition containing these components. The invention also encompasses methods for inducing or inhibiting differentiation of fibroblasts to myofibroblasts, in vivo as well as in vitro, and screening methods for identifying other agents that modulate myofibroblast differentiation.
    Type: Grant
    Filed: March 16, 2001
    Date of Patent: November 8, 2005
    Assignee: The Regents of the University of California
    Inventors: Manuela Martins-Green, Jo Ellen Feugate, QiJing Li
  • Chemokines and methods for inducing the differentiation of fibroblasts to myofibroblasts
    Publication number: 20030040109
    Abstract: This invention is based on the discovery that chemokines induce fibroblasts to differentiate to myofibroblasts, which play a critical role in wound healing and are implicated in a number of fibrotic diseases. This activity has been localized to a peptide in the N-terminus of several chemokines. Accordingly, the invention provides polypeptides that induce the differentiation of fibroblasts to myofibroblasts in vitro and in vivo, nucleic acids encoding such polypeptides and related vectors, host cells, and composition containing these components. The invention also encompasses methods for inducing or inhibiting differentiation of fibroblasts to myofibroblasts, in vivo as well as in vitro, and screening methods for identifying other agents that modulate myofibroblast differentiation.
    Type: Application
    Filed: March 16, 2001
    Publication date: February 27, 2003
    Inventors: Manuela Martins-Green, Jo Ellen Feugate, QiJing Li